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Tofranil (Imipramine)
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Tofranil

Tofranil is in a class of medications called tricyclic antidepressants. It treats depression by increasing the amounts of certain natural substances in the brain that are needed to maintain mental balance. There is not enough information to explain how Tofranil prevents bedwetting.

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Also known as: Imipramine

Description

Tofranil is a tricyclic antidepressant used to treat symptoms of depression. This medicine is sometimes used to treat bed-wetting in children ages 6 and older.

Dosage

This section provides information on the proper use of a number of products that contain imipramine. It may not be specific to Tofranil-PM. Please read with care.

Take this medicine only as directed by your doctor to benefit your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (capsules): For depression: Adults—At first, 75 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 200 mg per day, unless you are in the hospital. Some hospitalized patients may need higher doses. Teenagers and older adults—At first, 25 to 50 mg per day using the tablets. Your doctor may adjust your dose as needed and switch you to the capsule form. However, the dose is usually not more than 100 mg per day. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets): For depression: Adults—At first, 75 milligrams (mg) per day. Your doctor may adjust your dose as needed. However the dose is usually not more than 200 mg per day. Some hospitalized patients may need higher doses. Teenagers and older adults—30 to 40 mg per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 100 mg per day. Children—Use and dose must be determined by your doctor. For enuresis (bedwetting): Children 6 years of age and older—At first, 25 milligrams (mg) once a day, taken 1 hour before bedtime. Your doctor may adjust the dose as needed. Children younger than 6 years of age—Use and dose must be determined by your doctor.

Overdose

If you overdose Generic Tofranil and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Tofranil overdosage: agitation, bluish skin, convulsions, difficulty breathing, dilated pupils, drowsiness, heart failure, high fever, involuntary writhing or jerky movements, irregular or rapid heartbeat, lack of coordination, low blood pressure, overactive reflexes, restlessness, rigid muscles, shock, stupor, sweating, vomiting.

Storage

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Tofranil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Generic Tofranil if you are allergic to Generic Tofranil components. Be very careful with Generic Tofranil if you are pregnant, planning to become pregnant, or are breast-feeding. Do not take Generic Tofranil if you are recovering from a recent heart attack or take MAO inhibitors, such as the antidepressants Nardil and Parnate. Be very careful with Generic Tofranil if you have diabetes, hypoglycemia, a history of mental disorders. Be very careful with Generic Tofranil if you are taking albuterol (Proventil, Ventolin), antidepressants that act on serotonin, including Prozac, Paxil and Zoloft, antipsychotic drugs such as Mellaril and chlorpromazine, barbiturates such as Nembutal and Seconal, blood pressure medications such as Catapres, Carbamazepine (Tegretol), cimetidine (Tagamet), decongestants such as Sudafed, drugs that control spasms, such as Cogentin, Epinephrine (EpiPen), Flecainide (Tambocor), Guanethidine, Methylphenidate (Ritalin), Norepinephrine, other antidepressants such as Elavil and Pamelor, Phenytoin (Dilantin), Propafenone (Rythmol), Quinidine, thyroid medications such as Synthroid, tranquilizers and sleep aids such as Halcion, Xanax, and Valium. Avoid alcohol. Do not participate in any activities that require full alertness if you are unsure about your ability. Try to stay out of the sun as much as possible. It can be dangerous to stop Generic Tofranil taking suddenly.

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Development of a Multiplex PCR Assay for Detection of Pseudomonas fluorescens with Biofilm Formation Ability. The findings demonstrate the advantages of gallbladder aspiration in elective cases. Authors report that this method of teaching-learning has been implemented successfully in nursing and occupational therapy programs and would benefit other academic programs in the health sciences, particularly in courses that cover controversial issues. Treatment for the unresectable primary liver cancer should be individualized and combined with suitable therapeutic modalities. Findings demonstrate that patients diverted to alternative forms of acute psychiatric care are no less in need of medical services than those admitted to hospitals.

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Resistance to amprenavir was the rule both before and after LPV/r treatment. Studies of more cases with longer follow-up durations are required. However, the underlying models, methods, and suited study design are often unknown. Genetically modified tumour vaccines producing IL-12 augment chemotherapy of HPV16-associated tumours with gemcitabine. Signal changes in standing magnetic resonance imaging of osseous injury at the origin of the suspensory ligament in four Thoroughbred racehorses under tiludronic acid treatment. There were more erythroid than myeloid cells in the S and G2M phases of the cell cycle. Second, these drugs are associated with less overall treatment-related toxicity. Evidence continues to support a role for sleep in delayed learning without further practice. In this study, we aimed to compare the change in microbial abundance on eggshells during incubation between urban and rural populations of a passerine bird, the Eurasian Magpie (Pica pica), and examine the consequences of any differences in microbial abundances in terms of hatching success and nestling survival. Samples were from seven representative background sites with a total of 162 plant samples from 38 different species.

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Our aim was to determine if those cells could transdifferentiate, even at low frequency, into insulin-producing cells, in testing optimized experimental conditions. These results suggest that the (alpha/alpha)(6) barrel represents a steady fold for presenting active-site residues in a cleft at the N-terminal ends of the inner alpha helices, thus forming a fine-tuned catalytic site in GlcNAc 2-epimerase. In this paper, the correlation between properties of hafnium dioxide thin films and preparing parameters was systematically researched by using the orthogonal experiment design method. Accurate metal-site structures in proteins obtained by combining experimental data and quantum chemistry. The incidence of stent thrombosis did not differ significantly between patients with drug-eluting stents and those with bare-metal stents in randomized clinical trials, although the power to detect small differences in rates was limited. In normal mucosa, the epithelial basement membrane showed an intense immunoreaction for type IV collagen. This study measured the effects of a TLIF on the overall and segmental flexibility of the lumbar spine using four different spinal implant configurations. Staining of NADPH-d-positive neurons with all their processes and preceding study of neurons of dorsal thalamus using Golgi method enabled the identification of their types and their determination as sparsely-branched cells. Mouse pancreatic development is critically dependent on epithelial-mesenchymal interactions.

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Another scenario for the organization of colloquia for continuing education of primary care physicians. In this paper, we propose a more natural formulation, called Spherical Code (SC), to directly maximize the minimal angle between different samples in single or multiple shells. The result suggests that DYZ1 faithfully records all the genetical changes occurring after the twining which may be ascribed to the environmental factors. Computational and experimental studies of size and shape related physical properties of hydroxyapatite nanoparticles. Nanoparticles having a size from 1 to 100nm are present in nature and are successfully used in many products of daily life. Mapping surface-modified titania nanoparticles with implications for activity and facet control. Surprisingly, cells bearing a chimera composed of the glypican extracellular domain fused to the syndecan transmembrane and cytoplasmic domains bind to collagen but remain invasive, implying that adhesion to collagen is not by itself sufficient to inhibit invasion. Lymphostin (LK6-A), a novel immunosuppressant from Streptomyces sp. For the water-borne component the dominant frequency range was 20-100 Hz with a source SPL of 121-125 dB at 1 m. Use of endobronchial laser ultraviolet irradiation in the complex treatment of bronchial tuberculosis.

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Cardiovascular risk factors, particularly low-density lipoproteins (LDL), give rise to atherosclerosis and its complications by triggering a dysfunctional endothelium, inflammation, and a procoagulant vascular surface. To investigate the elemental composition of melanin granules in virgin black hair and bleached hair, these hair cross-sections are analyzed by using a nanoscale secondary ion mass spectrometry (NanoSIMS). Insulin-like growth factor-I (IGF-I) has endocrine, autocrine and paracrine properties. We found that the stratum corneum thickness of CS-treated mice was increased in comparison with that of vehicle-treated mice. Antiepileptic effects of topiramate on amygdaloid kindling in rats. However, because of its rarity, the long-term response and relapse rates after immunosuppressive therapy are largely unknown, and optimal management of this disorder remains unclear. The results of the present study suggest that the laxative effect of MgSO(4) is not simply caused by a change in the osmotic pressure in the intestinal tract, but could be a response to increased expression of AQP3. A small-molecule enhancer of signal transducer and activator of transcription 1 transcriptional activity accentuates the antiproliferative effects of IFN-gamma in human cancer cells. The goal of this study was to determine the effect of psychoactive substances (drugs) on the presence and frequency of oral Candida species and Candida dubliniensis. The purpose of this study was to develop a web-based open source platform to support a multi-centre clinical trial.

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Unilateral ANT electrical stimulation and lesioning significantly reduced clinical seizure frequency, compared with control animals. Spinal cord injury causes sensory loss below the level of lesion. Clinical data demonstrating improved outcomes are so far lacking for robotic surgical application within the abdomen. Therefore, DGF is attributed to high intracellular calcium levels. The use of mycophenolate is first-line adjuvant therapy in the treatment of pemphigus vulgaris and pemphigus foliaceus. Furthermore, we show that the longitudinal field component crucially depends on the pulse velocity and that it can be neglected only if the velocity is slightly greater than c.

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After the treatment was completed, successful portal vein recanalization was demonstrated on ultrasonography or multidetector three-dimensional computed tomography angiography in all five cases. Taking into account that few investigations refer to the functions of growth in the maxillaries, our aim was to identify the TGF-beta1 immunohistochemical expression pattern in the maxillaries of growing rats. The effects of current asthma therapy on oxidative stress are currently unclear, but previous trials using conventional antioxidant therapy in asthma have been largely ineffective. In Korean school-aged children, vitamin D insufficiency were relatively higher and may be closely related with higher BMI. However, the colpostat separation should be kept to a minimum, and vaginal packing should be applied with great care to avoid generating cold spots along the upper vaginal surface and vaginal cuff. Under normoxic conditions, the AtERF73/HRE1-RNAi seedlings displayed increased ethylene sensitivity and exaggerated triple responses, indicating that AtERF73/HRE1 might play a negative regulatory role in modulating ethylene responses. All of the isolates from ten outbreaks in the Kinki region (midwestern part of Japan) in July-August 1996 were grouped into the same PFGE type (IIa) and PT 32, while among total isolates, there were such varieties as PFGE type IIa containing five phage types and PT32 containing two PFGE types.

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Sparse Supervised Classification Methods Predict and Characterize Nanomaterial Exposures: Independent Markers of MWCNT Exposures. Epidemiology of rickettsiosis resembling murine typhus in Sicily. The C allele carrier for rs12313273 was strongly related to recurrent stone forming in patients. To determine the pressure and traction forces exerted on a model fetal head by the BD Odon Device, forceps and Kiwi ventouse during simulated births. As expected for a free-surface phenomenon, the surface relaxation temperature was found to be independent of film thickness in the range of 0.1-0.5 microm. Manometric investigation of high-amplitude propagated contractile activity of the human colon. A comparative analysis of the stop-flow LC-NMR (1H and TOCSY) and LC-MS data provided evidence that A is structurally related to acarbose, differing from the parent compound in a number of subunits present in the molecule. The patient recovered following catheter removal and treatment with levofloxacin and minocycline for one month.

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The selective processing of briefly presented affective pictures: an ERP analysis. However, few studies have investigated the influence of genetics on the Heath-Carter somatotype. To describe the clinical features of PAL injury, determine its prevalence with or without subcutaneous fibrosis ventolin max dose pediatric and/or concurrent injury within the DFTS, and assess response to treatment. Two authors independently screened the search results, assessed trial quality and extracted data using the standard methodological procedures expected by The Cochrane Collaboration. Though the model, we deduce the closed-form expression for the outage probability as the metric of this network.

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The aim of this study is to investigate whether GDF-15 will be of benefit in predicting LV remodeling, heart failure and death in patients with STEMI. Histopathology revealed milia surrounded by a dense lymphocytic infiltrate. Epigallocatechin gallate supplementation protects against renal injury induced by fluoride intoxication in rats: Role of Nrf2/HO-1 signaling. Among essential elements, higher Fe and lower Cu levels were specifically found in the liver of Baikal seal. The patients were classified as DM-type 1 and 2, with and without diabetic retinopathy (DR). Awaiting the results of larger sample size and more quantitative studies, the benefits of frequent fruit consumptions should be part of public health education. Studies have suggested that antibiotics are often inappropriately prescribed for the treatment of pharyngitis despite clinical evidence and international guidelines. Donor-specific transfusion-induced tolerance: mechanisms revisited. Production of IgG1 was seen across the full range of bead sizes, increasing after two immunizations. A case of a primary carcinoid tumor of the testis which occurred in a 57-year-old man is reported.

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Unintentional events as results of registration of unintentional events?. Secondly, the procedure for temperature calculation around the antennas and the calculation model based on the CT images of the patient are described. Furthermore, prophylactic, restorative and surgical dental care of patients with bleeding disorders is best accomplished by practitioners who are knowledgeable about the pathology, complications and treatment options associated with these conditions. There was no evidence of relapse during the three-year follow-up after operation. Our method of pancreatojejunal reconstruction adds to the armamentarium of the pancreatic surgeon.

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Individual and strain differences in patterns of long-term persistence of urethane-induced sister chromatid exchanges (SCEs) in mouse lymphocytes and their relation to carcinogen susceptibility. A modified clinic technique in a visual survey of a first grade population. A cross-cultural comparison of British and Chinese beliefs about the causes, behaviour manifestations and treatment of schizophrenia. This approach takes advantage of the ability of grooved channel walls oriented at an angle to the direction of an external electric field to generate a transverse electroosmotic flow. Systematic phosphoproteomics analysis performed in cells lacking the mTORC2 component Rictor in the absence or presence of Torin, an inhibitor of both mTORC1 and mTORC2, revealed mTORC1-dependent substrates regulated during infection. All three patients had received at least one previous verteporfin treatment in the study eye. The recruitment of distinct arrays of protein complexes to trans-Golgi network membranes is likely to produce the diversity of structure and biochemistry observed amongst subdomains that serve to generate different carriers or maintain resident trans-Golgi network components. Apart from that, the factors influencing solubility of Cr(VI) in soil have also been investigated. Twelve 5- and 7-wk-old male chickens of each line were exposed at two different ambient temperatures, 10 and 25 degrees C. To assess the MRSA transmission from livestock to humans, we have grouped MRSA strains according to antimicrobial susceptibility patterns against the tested antibiotics.

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Analysis of 2-dimensional contingency charts in medical, sociological risperdal consta maximum dose and epidemiological studies with the aid of information statistic 21. Expedited partner therapy for sexually transmitted diseases: assessing the legal environment. Understanding what aspects of the dying process motivate terminally ill individuals to consider hastening their death, can lead to improving end-of-life care. To explore the effects of recombinant human Elafin gene transfection on lipopolysaccharide (LPS)-induced airway mucous hypersecretion. A kit of lenses, which permits to carry out a laser investigation and treatment of the fundus of the eye and the angle of anterior chamber of the eye is described.

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A serine peptidase responsible for the inactivation of endogenous cholecystokinin in brain. To examine the use of ACE inhibitors and ARBs in members of a Medicaid managed care organization (MCO) with diabetes and a diagnosis of hypertension and/or kidney disease to determine to what extent (1) physicians are conforming to the recommended course of treatment according to ADA guidelines published in 2002 and still current and (2) patients are adhering to their prescribed therapy. p56lck is also associated with detergent-insoluble structures in a lymphoid cell line, LSTRA. Histological examination found amaryl 8 mg a distinctive papillary growth pattern in which the vessels were covered by multiple layers of tumor cells. Protozoa cause chronic and persistent infections, because natural immunity against them is weak and because protozoa have evolved multiple mechanisms for evading and resisting specific immunity. We hypothesized that the Network Modification Tool could predict remote brain tissue loss caused by poststroke loss of connectivity. Chronic myeloid leukemia (CML) is the commonest hematological malignancy in India. In the present work, HO-1 expression in trinitrobenzene sulphonic acid (TNBS)-induced colitis in the rat and the effects of HO-1 modulation, particularly by the HO-1 inducer, heme, were further evaluated. Severe leptospirosis is frequently complicated by a hemorrhagic diathesis, of which the pathogenesis is still largely unknown.

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Photoelectrochemical (PEC) water splitting provides an attractive route for large-scale solar energy storage, but issues surrounding the efficiency and the stability of photoelectrode materials impose serious restrictions on its advancement. Expression of recombinant psoriasis-associated fatty acid binding protein in Escherichia coli: gel electrophoretic characterization, analysis of binding properties and comparison with human serum albumin. We report a case of right posterior sectoral artery pseudoaneurysm detected 2 weeks after laparoscopic cholecystectomy and successfully repaired laparoscopically. It is proposed that AGS3 gates the expression of cocaine-induced plasticity by regulating G protein signaling in the PFC. Here we introduce a chiral separation of this metabolite using supercritical fluid chromatography/mass spectrometry.

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