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Sustiva

Sustiva belongs to a class of drugs known as non-nucleoside reverse transcriptase inhibitors (NNRTIs). This drug is used with other HIV medications to help control HIV infection. It helps to decrease the amount of HIV in your body so your immune system can work better.

Other names for this medication:
Cytocom, Duovir, Efavir, Efavirenz, Efcure, Efferven, Emduo, Estiva, Evirenz, Lamivir, Lazid, Odivir, Retrodel, Revenz, Tenola, Trioday, Trustiva, Viraday, Viranz, Virocmb, Virolis, Vonavir, Zidolam

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Also known as: Efavirenz

Description

Sustiva (efavirenz) is an antiviral medicine that prevents human immunodeficiency virus (HIV) from multiplying in your body.

Sustiva is used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS).

Sustiva is for adults and children who are at least 3 months old and weigh at least 8 pounds. This medicine is not a cure for HIV or AIDS.

Dosage

Usual Adult Dose for HIV Infection:

600 mg orally once a day Comments: -This drug should be used with a protease inhibitor and/or NRTIs. Use: In combination with other antiretroviral agents, for the treatment of HIV-1 infection

Usual Adult Dose for Nonoccupational Exposure:

US CDC recommendations: 600 mg orally once a day Duration of therapy: 28 days Comments: -This drug should be used with (lamivudine or emtricitabine) plus (zidovudine or tenofovir); recommended as the preferred NNRTI-based regimen for nonoccupational postexposure prophylaxis of HIV infection. -Prophylaxis should be started as soon as possible, within 72 hours of exposure. -Not approved by US FDA.

Usual Adult Dose for Occupational Exposure:

US Public Health Service working group recommendations: 600 mg orally once a day Duration of therapy: 28 days, if tolerated Comments: -An alternative antiretroviral agent for use as HIV postexposure prophylaxis only with expert consultation -Prophylaxis should be started as soon as possible, preferably within hours after exposure. -The optimal duration of prophylaxis is unknown and may differ based on institution protocol. -The most current therapeutic guidelines should be consulted for more information. -Not approved by US FDA.

Usual Pediatric Dose for HIV Infection:

3 months or older: 3.5 to less than 5 kg: 100 mg orally once a day 5 to less than 7.5 kg: 150 mg orally once a day 7.5 to less than 15 kg: 200 mg orally once a day 15 to less than 20 kg: 250 mg orally once a day 20 to less than 25 kg: 300 mg orally once a day 25 to less than 32.5 kg: 350 mg orally once a day 32.5 to less than 40 kg: 400 mg orally once a day 40 kg or more: 600 mg orally once a day Use: In combination with other antiretroviral agents, for the treatment of HIV-1 infection

Detailed Sustiva dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Sustiva are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Drinking alcohol can increase certain side effects of efavirenz.

Using this medicine will not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

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In a novelty test, piracetam increased the rate of loss of interactions with the novel object. Apolipoprotein B-100 (apoB-100) is degraded by endoplasmic reticulum-associated degradation (ERAD) when lipid availability limits assembly of VLDLs. Applying the chain formation model to magnetic properties of aggregated ferrofluids. Heteraxinoides xanthophilis, a gill parasite of the spot, Leiostomus xanthurus, has an asymmetrical triangular-shaped haptor with multiple clamps situated along its edges. Low-affinity kainate receptors and long-lasting depression of NMDA-receptor-mediated currents in rat superficial dorsal horn. The effect of succinic acid monomethyl ester (SAM) on the responses of isolated thoracic aorta in streptozotocin-diabetic rats. Filamentous fungi, including the ascomycetes Monascus, Fusarium, Penicillium and Neurospora, are being explored as novel sources of natural pigments with biological functionality for food, feed and cosmetic applications. The first is learning about the instrumental contingency between the response and reward, whereas the second consists of the acquisition of incentive value by the reward. Opportunistic Infections (OIs) and co-infections are the major cause of deaths amongst HIV infected individuals and this mostly depends upon the risk factors, type of exposure and geographic region. Herein, a distinctive structure of cathode material is proposed, which can simultaneously satisfy these requirements.

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