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Provigil (Modafinil)
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Provigil

Provigil is a medication to treat sleepiness due to narcolepsy, shift work sleep disorder or obstructive sleep apnea. While it has seen off-label use as a purported cognitive enhancer to improve wakefulness in animal and human studies.

Other names for this medication:
Alertec, Carim, Dekast, Modafinil, Modafinilo, Modalert, Modapro, Modatec, Modavigil, Modfil, Modiodal, Provake, Renea, Vigia

Similar Products:
Atarax, Pepcid, Imovane, Actos, Suprax, Levlen, Alcalm, Perclin, Defidin, Amnorm, Nofocin,

Also known as: Modafinil

Description

How Provigil works to help increase wakefulness and decrease sleepiness isn’t clear. The drug works in the brain to increase amounts of certain chemical messengers such as dopamine. It also seems to affect the messenger glutamate in certain areas of the brain.

These actions may result in stimulation of brain activities, which could make you feel less tired.

How long does it take to work?

Provigil begins to work within 30 to 60 minutes of when you take it. If you take it with food, the drug might take slightly longer to start working.

Dosage

Usual Adult Dose for Narcolepsy:

200 mg orally daily in the morning

Usual Adult Dose for Obstructive Sleep Apnea/Hypopnea Syndrome:

200 mg orally daily in the morning

Usual Adult Dose for Shift Work Sleep Disorder:

200 mg orally daily one hour prior to the start of the work shift

Usual Pediatric Dose for Attention Deficit Disorder:

Not FDA approved. Reports of serious dermatologic adverse effects and psychiatric events has resulted in the FDA's Pediatric Advisory Committee unanimously recommending that a specific warning against the use of modafinil in children be added to the manufacturer's labeling; use only if first- and second-line treatments have failed and the benefits outweigh the risks. Children less than 30 kg: 200-340 mg once daily Children more than 30 kg: 300-425 mg Randomized, double-blind, placebo-controlled pediatric studies have utilized an 85 mg film-coated tablet (currently not commercially available) to provide these dosages. All studies utilized a titration method but varied the length of titration (3 weeks vs 7-9 days); clinical improvement was noted earlier in the shorter titration period.

Detailed Provigil dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of reach of children.

Side effects

The most common side effects associated with Provigil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Avoid other dangerous activities until you know how Provigil will affect your level of wakefulness.

Avoid drinking alcohol while taking modafinil.

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Higher concentrations of Cu bound to the cell wall and uronic acid in the roots of S. High frequency of silent brain infarcts associated with cognitive deficits in an economically disadvantaged population. Lysozyme, used to prepare osmotically fragile cells, combines with ribosomal subunits unless salt is present in excess of 50 mM. This study demonstrates that cynomolgus monkey islets can be successfully and efficiently harvested using a simple isolation method, and these islets can restore normoglycemia in monkeys with diabetes. The objectives of this study are to measure sleep quality, sleepiness, fatigue, and vigilance in inpatient nurses and to assess how setting (intensive care unit versus the general floor) and shift worked (day versus night) affect these measures. The cremaster muscle of anesthetized rats (Nembutal, 50 mg/kg, ip) was surgically exposed and maintained in a controlled bath environment for in vivo television microscopy.

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The number of patients with lesions noted on MRI and the overall cost of imaging the patients were determined. Similar results were obtained with a chimeric alphavbeta8 including the beta6 cytodomain (alphavbeta8/6), showing that the beta6 cytodomain can substitute efficiently for the corresponding region of beta8. The role of oxygen radical-mediated signaling pathways in endometrial function. We retrospectively evaluated the value of the combination of ultrasonographic guidance for jugular vein puncture and an automated biopsy device for transjugular liver biopsy. In vitro activities of PD 117,596 and reference antibiotics against 448 clinical bacterial strains. Factor 8 in a female patient with haemophilia A during pregnancy.

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Comparative investigation of type-a2 AQPs in anurans further revealed that AQP-h2 and -h3-like molecules might exist at the urinary bladder and the pelvic skin, respectively, in various anurans from aquatic species to arboreal dwellers. Relaxation oscillations emerge when the time scales between the activators and the inhibitors are well separated. The aim of this study was to examine the anti-fibrotic effect of the HMG-CoA-reductase-inhibitor, cerivastatin, in COL4A3 knockout mice, an animal model of Alport syndrome with progressive renal fibrosis. These findings strongly support a pathogenic role of the APC N1026S variant in the AFAP phenotype, reinforcing the importance of functional characterization of APC variants for genetic counseling. A model is emerging for how these factors are regulated to control T-cell responsiveness. A 76-year-old man was admitted to our hospital with abdominal pain, nausea, and vomiting. Two hundred forty-two patients receiving IVF treatment and 81 control patients. Joint intensity inhomogeneity correction for whole-body MR data. At the end of this process, a tool named Inclusive Design Advisor was developed, combining data related to design features of small appliances with ergonomic task demands, anthropometric data and exclusion data.

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Adult neurogenesis occurs in discrete regions of the adult mammalian brain and is known to be tightly regulated by various physiological, pathological and pharmacological stimuli. The findings of the present research are suggestive of a possible trend and an association of dermatoglyphic features with children suffering from ALL. Fifty five per cent of the women who were given the questionnaire about media publicity responded. This report summarizes 7 years of prospective data from the state of Florida, the best data available on office surgery incidents. Data were analyzed for demographics, stage at presentation, treatment modality, and overall survival and cancer-specific survival. A consequence of adaptations in metabolic rate is the production of mitochondria-derived reactive oxygen species. However, the perceived instability of these compounds and typically high cost of collection and analysis may make their measurement impractical, particularly in large-scale studies. In Study 2, Confirmatory Factor Analysis was carried out to compare competing models that were constructed based on theoretical considerations and the results of Study 1. SD rats were randomly divided into 3 groups: sham operation (S) group, SAP group, and LMWH treatment (LT) group.

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The enhancement of gliomas and metastases was weak and often absent. A two-fold increase in cathepsin G mRNA was observed in atheroma plaque. The outcome was calculated for a 50-year-old patient with 30 years of follow-up after initial polypectomy. A total of 1491 RA patients included in the French REGistry-RoAcTEmra were analysed to calculate the incidence rate of first serious infections rate after initiation of tocilizumab. Several trends in the technology and where it is likely to go in the future are also discussed. Injury rates were approximately equal by gender and increased significantly with increasing age. The proportion of apoptotic beta cells was significantly lowered in the presence of rhPRL under both cell death-induced conditions. These results suggest that the neurite outgrowth-stimulating action of beta-casomorphin-5 may be mediated via a receptor which has mu-like characteristics and high sensitivity to beta-casomorphin-5, and that beta-casomorphins may play a role as a neurite elongation factor during the suckling period. Synthesis of fluorinated chiral amines using N-tert-butylsulfinyl imines. Multidimensional statistical analysis for a set of morpho- and physiological traits (anthropological, hemodynamic and biochemical) was done by the principal components method with interpretation of the latter.

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We found that the expansion rate of miRNAs was significantly higher compared to other genes in human evolution. The azanucleosides, azacitidine and decitabine, are front-line therapy for MDS that induce promoter demethylation and gene expression of the highly immunogenic tumor antigen NY-ESO-1. The relative distance information contained in the optic flow during translatory movements between saccades is provided to the SMI by the responses of the visual output neurons. A comparison of Hox3 and Zen protein coding sequences in taxa that span the Hox3/zen divergence. 12-Lipoxygenases were found in the cytosol fraction of bovine leukocytes and platelets.

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Ictal localization by source analysis of infraslow activity in DC-coupled scalp EEG recordings. Cytocompatility of the porous scaffolds were evaluated, using HL-7702 cells as model, in terms of cell attachment and cell viabilities from 3 to 72 hours determined by MTT method. Single cell PCR from archival stained bone marrow slides: a method for molecular diagnosis and characterization. To determine whether migraine interferes with health-related quality of life (HRQL) and the degree of disability caused by this condition in the daily life of children of both genders aged 6-12 years. Children who bullied or who were victimized only in childhood did not differ largely in adolescence from the children that were never bullies or victims. We find evidence of confined states in the region of both single and double bilayer Zb segments indicative of the formation of crystal segment quantum wells due to the smaller band gap of Zb as compared to Wz.

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The underdevelopment of the ORs might reflect the dysfunction of visual cortex in children with amblyopia. Crystallization and preliminary crystallographic analysis of earthworm fibrinolytic enzyme component B from Eisenia fetida. The most important ones--such as throwing the tooth on the roof, giving it to mice or hiding it in different places--occur in places which are very far distant from one another, indicating that these customs originate from ancestral cultures. RAMM can interpret MS/MS data containing modified nucleosides in two modes: fixed and variable. It is based on clinical picture, microbiological, histological, radiological, serologic and molecular examinations. For a load-free implant, osseointegration seemed to occur with a higher incidence at a roughened compared to a turned implant surface. This provides a mechanism that may explain some of the previously reported association of weight gain with an increased risk of both cancer and cardiovascular disease.

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The authors examine the appearance of these hernias at axial CT, as the axial plane remains the diagnostic mainstay of evaluation of acute abdomen. Total RNA was isolated from samples and processed for array hybridization with Affymetrix HG U133 Plus 2 arrays. Fifty-one men (16 lean, 19 abdominally obese, and 16 reduced obese) and 31 women (12 lean, 10 subcutaneously obese, and 9 reduced obese) were selected to participate to this study. The interactions of the Eu(III) trinuclear complex with some potentially interfering ligands are qualitatively investigated by means of luminescence titrations. Radioimmunoassay of thromboxane B2 in plasma: methodological modifications.

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Innovative use of LC-MS/MS for simultaneous quantitation of neutralizing antibody, residual drug, and human immunoglobulin G in immunogenicity assay development. A convection-diffusion equation for membrane filtration is analytically solved assuming fast crossflow velocity of a simple shear flow tangential to the membrane surface. Within the upper 15-20 cm sediment in the disposal area, chlorobiphenyls are conservative, the variation in their concentration with respect to depth being related to historical input. The characterization of the molecular changes of the cartilage cells, the chondrocytes, enables a better understanding of the pathomechanisms of the disease. We detected VGLUT1 immunoreactivity (-ir), but not VGLUT2-ir and VGLUT3-ir, respectively, in many motor nerve terminals in motor endplates of the mouse esophagus as identified by alpha-bungarotoxin or colocalization of VGLUT1 with choline acetyltransferase. We describe a case of an early vascular complication that was successfully treated with angiographic embolization in a to simultaneous pancreas-kidney transplant patient. The outbreak was attributed to the intake of raw freshwater crabs while on tourist trips in a mountainous area. To investigate the effect of modified Qianyang Pellet (MQYP) on extravascular lung water and its correlated factors at the early fluid resuscitation stage of septic shock. To study the distribution of estrogen receptor (ER) subtypes in ovarian tumors and to correlate the levels of expression with clinical factors. Our patient underwent a radical enlarged mastectomy, but due to the extension a radical removal was not possible.

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In the presence of the insertion alone, a decrease of the RC was observed, which seemed to be compensated by the presence of other mutations. The periodic bendability profile shows bending peaks roughly at every 10 bp with stronger bending at 20 bp intervals. Analysis of Peroxisome Biogenesis in Pollen by Confocal Microscopy and Transmission Electron Microscopy. Drug monitoring of mycophenolic acid in the early period after renal transplantation. Visceral adipose tissue may be a mechanism through which exercise reduces the risk of disease recurrence among colon cancer survivors.

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In conclusion, sufficient analgesia is a correct strategy (rather than muscle relaxant administration) for performing intraoperative patient immobility and for providing patients with good and safe intraoperative anaesthesia management by protecting them from noxious reflexes and stress including autonomic reactions such as hypertension and tachycardia. Using population segmentation to inform local obesity strategy in England. CT scans were repeated 1 day before surgery and compared with pretreatment scans (Lund-MacKay radiologic scoring system). Salicylic acid peels in polyethylene glycol vehicle for the treatment of comedogenic acne in Japanese patients. Dog 1 had a chronic nonproductive cough, but results of fecal flotation examination were negative. This article describes a patient with an extra-adrenal pheochromocytoma who presented with symptoms associated with voiding. Integrated optical density (IOD) served as the measurement parameter.

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Adolescents with chronic pain syndromes can face significant challenges in accomplishing developmental goals with respect to the pain and disability they experience. Careful analysis of the magnetic behaviour indicates the origin of the exchange bias to be a phase separation between an A-type antiferromagnetic phase and a low temperature highly anisotropic phase originating from another ordering at the rare-earth sublattice. The telomeres were present at the two ends of the satellited chromosome 2. The time from stroke onset to entry ranged from a few hours to six months, but most patients were recruited within one month of acute stroke. The role of liquid-based cytology in the investigation of colorectal lesions: a cytohistopathological correlation and evaluation of diagnostic accuracy.

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Biotinylated N-Acetyllactosamine- and N,N-Diacetyllactosamine-Based Oligosaccharides as Novel Ligands for Human Galectin-3. We hypothesized that fish in groups are better at recognizing a parasitized area and avoiding it than solitary fish. Our findings showed that FAP was overexpressed in CAFs of gastric carcinomas, and siRNA-mediated knock down of FAP significantly suppressed invasion and migration of MGC-803 cells. Immunohistochemistry and HSCORE was used with frozen sections for integrins (alpha1beta1, alpha4beta1, alpha(v)beta3), and MUC1 (BC2) and paraffin sections for osteopontin and MUC1 (BC3). Further, radioisotopic fluxes showed that the increase in Isc in EOST-exposed tissues was accompanied by increased absorption of electrolytes (Na, Cl, and other ions), and the decrease in R was actos medication name brand accompanied by increased permeability to mannitol. Common predisposing factors include diabetes mellitus and immunosuppression. Here, to gain mechanistic understanding of these separate observations, we tested the prediction that CrPic would protect against insulin-induced insulin resistance by improving PM features important in cytoskeletal structure and insulin sensitivity. Most of them retained feeding on arthropods with transition of larvae to much more effective parasitic feeding provided with the additional specialization of the larval stage.

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This may reflect early physiologic changes due to radiation, which restrict prostate motion. AJ mice were exposed daily for 6 months (6 h/day) to atmospheres containing one of four concentrations (30, 100, 300, and 1000 microg/m(3)) of diluted diesel exhaust (DE) in whole body exposure chambers. Prediction of outcome of anaesthesia in patients over 40 years: a multifactorial risk index. We postulate that extracellular materials of the cell surface, which may affect cell and tissue interactions, are shed in the environment together with plasma-membrane vesicles. Overall, the results of the evaluation showed that watching the videos resulted in an increase in knowledge, and participants had an overall positive experience with the URE videos. Delta-like 4 (Dll4), a membrane-bound Notch ligand, plays a fundamental role in vascular development and angiogenesis. Analysis of cases of stroke was carried out by gender, age, days and seasons by descriptive-analytical epidemiological methods. In 1999, at the age of 18, the patient had undergone enucleation of a dermoid cyst of the left ovary by laparotomy and a segment of the right ovary had been collected. Accurate antenatal exposure identification at delivery is an important form of tertiary assessment that warrants the development of improved screening methodology and standardization of hospital biological drug testing.

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The lack of novelty P3 habituation seen in the elderly is consistent with changes in frontal lobe function as age increases. This study attempts to determine which factors account for the spatial variation in teenage conception rates within the former Wessex Regional Health Authority and what factors account for the eventual outcomes of these conceptions. Development and content validity of the new version of a patient classification instrument. Polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like polychlorinated biphenyls (PCBs) in the serum of US Air Force veterans in 2002. When tests differ in structure, they may underestimate the relationship between implicit and explicit cognition. The oxygen effect - dependence of hydrogen peroxide formation on the concentration of molecular oxygen - was shown, and the participation of singlet oxygen, hydroxyl radicals and superoxide (hydroperoxide) radicals in this process was testified. Report on the Meeting of the Working Group for Hematopathology : Annual Conference of the German Society for Pathology, Erlangen, 2017. The differentiated cells were evaluated pharmacologically, by immunocytochemistry, and so forth. Patient with stable COPD (no exacerbation in the last two months) were taken up for the study. Ultrafine PEG-coated poly(lactic-co-glycolic acid) nanoparticles formulated by hydrophobic surfactant-assisted one-pot synthesis for biomedical applications.

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A reconstruction of the skull, dentary and dentition of the middle Miocene ornithorhynchid Obdurodon dicksoni has been made possible by acquisition of nearly complete cranial and dental material. Glomus tumors of the lung are rare benign neoplasm, originating from modified smooth muscle cells. Among the biochemical responses which occur during TPA treatment is a decrease in procollagen synthesis. More work is needed to assess criterion validity because EON scores were not correlated with scores on a Census-based index used to measure quality of military neighborhoods. The effects of coal-smoke pollutants on the growth, yield and leaf epidermal features of Abelmoschus esculentus moench. Zirconia doped with a lanthanum oxide system is of high interest due to its exceptional thermal stability for the development of high-performance ceramics. Direct conversion of cyclic amines to lactams utilizing water as the only reagent is catalyzed by pincer complex 2. The patient was successfully submitted to complete surgical excision of the mass, which revealed to be a malignant sarcoma. Consistent with previous work, men reporting high levels of psychopathy failed to show the typical increase in the startle response when exposed to aversive photographs, but only when responses were elicited relatively early in picture viewing (i.e., 2.0 s as compared to 4.5 s post-photograph onset). They were slightly shortened but free of thrombosis or vegetation.

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Machine-learning algorithms can help infer semantic annotations from trajectory data by learning from sets of labeled data. Examine the characteristics of an essential tremor (ET) clinical cohort including base-rate variability of several commonly accepted diagnostic criteria. Rapid radioimmunoassay of gonadotropins (HCG, LH): method using anti-HCG polymer as the immunoadsorbent. In this study no disadvantageous effect of connecting teeth to implants as abutments by fixed partial dentures was found. Genetic distances among speakers of the European language families were computed by using gene-frequency data for human blood group antigens, enzymes, and proteins of 26 genetic systems. However, acceptance of the scientific data that an unrelated live donor transplant can now be performed successfully should not be misconstrued as an acceptance that an unrelated kidney may be purchased via a vendor sale. Assessing attitudes toward and beliefs about pain among Chinese patients with chronic pain: validity and reliability of the Chinese version of the Pain Beliefs and Perceptions Inventory (ChPBPI). Characterization of root initiation and root senescence in callus- and organ-cultures of is there a 10 mg nexium Daucus carota through determination of the specific activity of the glutamate-dehydrogenase (NAD).

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MLST analyses of Mmc strains revealed a distinct clustering of Australian isolates into a novel clade, with the closest relatives being strains from Europe. Seven studies evaluated treatment given directly to children, four investigated the effects of training for communication partners. They should be appropriately counseled regarding an increased risk of operative complications. The mean droplet size of emulsions prepared with lipids containing exclusively long-chain triglycerides showed a remarkable increase after 4 days of storage, in contrast with that tenormin atenolol dosage of the mixtures containing structured lipids. Since introduction of percutaneous transluminal coronary angioplasty and stents, much progress has been made.

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Dilated cardiomyopathy caused by plasma membrane carnitine transport defect. This study evaluates the effects of dietary fat levels and feeding durations on body composition, bone properties, and endocrine factors in female rats. Factorial ANOVAs showed that although there were some complexities in the manipulation, disgust and embarrassment predicted greater anticipated delay and avoidance of elicitors prometrium capsules inserted vaginally , but only among specific groups. Results were analyzed by descriptive statistics and chi-square analyses. Between prohibitions: patterns and meanings of magic mushroom use in the UK. Among them were yvyD, citA and the putative methylcitrate shunt genes mmgD, mmgE and yqiQ. Culture of semen has a lower sensitivity but is recommended for evaluation in selected men with problems with infertility. Inhibitory profiles of spices against free and protein-bound heterocyclic amines of roast beef patties as revealed by ultra-performance liquid chromatography-tandem mass spectrometry and principal component analysis. Caesarean section rates in Australia rose over the period 1999-2009, as did maternal age at first birth. Dispelling the myths and beliefs toward female genital cutting of woman: assessing general outpatient services at a tertiary health institution in Enugu state, Nigeria.

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The lack of a precursor and the panoply of genetic aberrations present in identified osteosarcomas makes study of its initiation difficult. Micropapillary carcinoma has become a dominant type of thyroid malignancy in Turkey. As a novel technology with a large variability in software, processing tools and printing techniques, there is not a standardized method by which a clinician can go from an imaging data-set to a complete model. To analyze the long-term efficacy of 2 interventions for female fibromyalgia (FM) patients: 1) cognitive-behavioral therapy (CBT), and 2) a physical exercise (PE)-based strategy. Special pharmacokinetics of dipetarudin suggests a rulide 150 mg tablets potential antitumor activity of this thrombin inhibitor. Umbilical cord blood stem cells can expand hematopoietic and neuroglial progenitors in vitro. One approach to understanding the genetic basis of traits is to study their pattern of inheritance among offspring of phenotypically different parents. No relevant side effects were seen in patients with significant fluid absorption.

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