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Moduretic (Amiloride)
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Moduretic

Moduretic is a new, orally administered, potassium-sparing diuretic with mild natriuretic and diuretic properties. Its primary site of action is the distal tubule of the nephron where it selectively blocks sodium transport, thereby inhibiting sodium-potassium exchange.

Other names for this medication:
Acuren, Adelphan, Amiloretic, Angiozide, Aquazide, Berlipril, Bisocombin, Bumeftyl, Cosaar, Crinoretic, Dithiazide, Duradiuret, Dytenzide, Dytide, Enaplus, Epratenz, Eprosartan, Esidrex, Fosicombi, Fosicomp, Fozide, Gentipress, Hidroclorotiazida, Hidroronol, Hydrex, Inhibace, Iperton, Lisoretic, Lispirl, Maxsoten, Monopril, Nephral, Prestole, Propra, Quinaretic, Renacor, Selokomb, Tevafos, Tevanap, Triamizide, Triampur, Turfa, Vaseretic, Zoprazide

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Also known as: Amiloride

Description

Moduretic is a diuretic (water pill) and a combination of a potassium-sparing diuretic (amiloride) and a thiazide diuretic (hydrochlorothiazide). It works by making the kidneys eliminate sodium (salt) and water from the body, which helps to lower blood pressure. The amiloride component helps minimize potassium loss. Brand name of Moduretic is Moduretic.

Dosage

Follow all directions on your prescription label. Do not take Moduretic 5-50 in larger or smaller amounts or for longer than recommended.

Take Moduretic 5-50 with food.

Your blood pressure will need to be checked often. Your blood and urine may also be tested if you have been vomiting or are dehydrated.

If you need surgery or medical tests, tell the doctor ahead of time that you are taking medication that contains hydrochlorothiazide. You may need to stop using the medicine for a short time.

If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Store at room temperature away from moisture, heat, and light. Do not freeze.

Detailed Moduretic 5-50 dosage information

Overdose

If you overdose Moduretic and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Do not freeze. Keep container closed tightly. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Moduretic are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Moduretic if you are allergic to Moduretic components or to any ingredient in Moduretic or any other sulfonamide (eg, sulfamethoxazole). Be careful with Moduretic if you're pregnant or you plan to have a baby, or you are a nursing mother. Be careful with Moduretic if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement. Be careful with Moduretic if you have allergies to medicines, foods, or other substances. Be careful with Moduretic if you have cirrhosis or liver problems, diabetes, gout, kidney problems or kidney stones, asthma, heart problems, or systemic lupus erythematosus. Be careful with Moduretic if you have elevated blood acid, low folic acid levels, or electrolyte problems, or are dehydrated. Be careful with Moduretic if you take potassium-sparing diuretics (eg, spironolactone), potassium supplements, or salt substitutes containing potassium because high blood potassium levels may occur and cause listlessness, confusion, abnormal skin sensations of the arms and legs, heaviness of limbs, slowed heart rate, irregular heart rhythm, or stopping of the heart; cholestyramine or colestipol because they may decrease Moduretic 's effectiveness; nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, indomethacin) because they may decrease Moduretic 's effectiveness and risk of kidney problems may be increased; barbiturates (eg, phenobarbital), certain chemotherapy medicines, corticosteroids (eg, prednisone), digoxin, dofetilide, ketanserin, narcotic pain medicines (eg, codeine), or medicines for high blood pressure because the risk of their side effects may be increased by Moduretic; diazoxide, lithium, or nondepolarizing neuromuscular blockers (eg, pancuronium) because their actions and the risk of their side effects may be increased by Moduretic; angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) because the risk of high blood potassium and kidney problems may be increased by Moduretic; diabetes medicines (eg, glipizide) or insulin because their effectiveness may be decreased by Moduretic. Do not stop taking Moduretic suddenly.

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Reproductive state was assessed by response to estradiol-negative feedback, monitored as serum LH in ovariectomized ewes bearing estradiol implants. The syndrome has known associations with several drugs used during anesthesia, including rocuronium and isoflurane. There is as yet no evident effect of this potential virus on parasite physiology or the disease caused by the parasite. From September 2001 to December 2005, 28 patients with 31 cavernous dural arteriovenous fistulae were treated with transvenous embolization in Beijing Tiantan Hospital. The findings underline the importance of careful psychopathological assessment of dissociative symptoms in the entire range of mental disorders. Novel partial nitritation treatment for anaerobic digestion liquor of swine wastewater using swim-bed technology. Recently, the AHR was shown to control host immunity by affecting the balance between inflammatory T cells that produce IL-17 (Th17) and IL-22 versus regulatory T cells (Treg) involved in tolerance.

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A clinical and histopathologic study with review of the literature. Suberin oligomeric blocks have been obtained after the partial depolymerization of the biopolymer, and in-situ studies by solid-state (13)C NMR spectroscopy have shown different molecular domains and how they are spatially related. The findings also suggested that location of the program, the times it was conducted, and the communication skills of significant healthcare workers who recruited participants were important factors affecting attendance. Leontiasis ossea in a patient with hyperparathyroidism secondary to chronic renal failure. Post-traumatic stress disorder is a common psychological maladaptation among adolescents after undergoing an earthquake. We explored the role of frontostriatal areas related to r-IGT performance using c-fos immunohistochemistry following the last training-session.

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Analyses of soluble proteolytic fragments derived from the rosettes indicated that aggregation is mediated by association of the conserved hydrophobic amino-terminal region of BHA2, the smaller glycopolypeptide component of each BHA subunit. The chromosomal analysis was normal and bcr/abl rearrangement was negative. Using the work loop technique, extensor digitorum longus and soleus muscles from mdm and wild-type (WT) mice were stimulated during the stretch phase of stretch-shortening cycles to investigate negative work. Twelve articles were selected from clinical (9) and experimental (3) studies, for qualitative analysis of the results. The model is based on the fact that most of the neuronal inputs have a finite lifetime. This approach has desirable theoretical properties: it takes the totality of data into account and does not suffer from numerical instabilities. Then, we performed fluidized bed granulation of the model formulation at steady-state moisture content levels under monitoring with NIR sensor, within and beyond the suitable range of added water that was calculated from the corresponding range of each component.

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