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Lunesta (Eszopiclone)

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Lunesta is a nonbenzodiazepine hypnotic agent used in the treatment of insomnia. It is slightly effective for this use. Lunesta is the active dextrorotatory stereoisomer of Lunesta, and belongs to the class of drugs known as cyclopyrrolones. It is also classified as a therapeutic sedative hypnotic and pharmacological cyclopyrrolone.

Other names for this medication:
Bexomer, Eszopiclone, Fulnite, Zolnite, Zopimin, Zopipure

Similar Products:
Paxil, Hydrea, Cardizem, Crestor, Abhigra, Losacor, Flavate, Melalite, Cefnil, Aptric, Acetensil, Funginoc,

Also known as: Eszopiclone


Lunesta is a nonbenzodiazepine hypnotic agent that is a pyrrolopyrazine derivative of the cyclopyrrolone class.

Lunesta is a white to light-yellow crystalline solid. Lunesta is very slightly soluble in water, slightly soluble in ethanol, and soluble in phosphate buffer.

Eszopiclone is formulated as film-coated tablets for oral administration. Lunesta tablets contain 1 mg, 2 mg, or 3 mg eszopiclone and the following inactive ingredients: calcium phosphate, colloidal silicon dioxide, croscarmellose sodium, hypromellose, lactose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, titanium dioxide, and triacetin. In addition, both the 1 mg and 3 mg tablets contain FD&C Blue #2.


Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Take Lunesta only if you are able to get a full night's sleep before you must be active again. Never take this medication during your normal waking hours, unless you have at least 8 hours to dedicate to sleeping.

Take Lunesta with a full glass of water.

Avoid taking Lunesta within 1 hour after eating a high-fat or heavy meal. This will make it harder for your body to absorb the medication.

Lunesta is for short-term use only. Tell your doctor if your insomnia symptoms do not improve, or if they get worse after using this medication for 7 to 10 nights in a row. Do not take Lunesta for longer than 2 weeks without your doctor's advice.

You may have withdrawal symptoms if you stop taking Lunesta after taking it over several days in a row. Do not stop taking Lunesta suddenly without first talking to your doctor. You may need to use less and less before you stop the medication completely.


In clinical trials with Lunesta, one case of overdose with up to 36 mg of Lunesta was reported in which the subject fully recovered. Since commercial marketing began, spontaneous cases of Lunesta overdoses up to 270 mg (90 times the maximum recommended dose of Lunesta) have been reported, in which patients have recovered. Fatalities related to Lunesta overdoses were reported only in combination with other CNS drugs or alcohol.

exaggerations of the pharmacological effects noted in preclinical testing. Impairment of consciousness ranging from somnolence to coma has been described. Rare individual instances of fatal outcomes following overdose with racemic zopiclone have been reported in European postmarketing reports, most often associated with overdose with other CNS-depressant agents.

General symptomatic and supportive measures should be used along with immediate gastric lavage where appropriate. Intravenous fluids should be administered as needed. Flumazenil may be useful. As in all cases of drug overdose, respiration, pulse, blood pressure, and other appropriate signs should be monitored and general supportive measures employed. Hypotension and CNS depression should be monitored and treated by appropriate medical intervention. The value of dialysis in the treatment of overdosage has not been determined.

As with the management of all overdosage, the possibility of multiple drug ingestion should be considered. The physician may wish to consider contacting a poison control center for up-to-date information on the management of hypnotic drug product overdosage.


Store Lunesta at room temperature away from moisture and heat.

Keep track of how many capsules have been used from each new bottle of this medicine. Lunesta is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.

Side effects

The most common side effects associated with Lunesta are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Lunesta if you are allergic to eszopiclone, or if you have ever taken sleep medicine and engaged in activity you later don't remember.

Lunesta is not approved for use by anyone younger than 18 years old.

To make sure Lunesta is safe for you, tell your doctor if you have ever had:

liver disease; a breathing disorder; depression, mental illness, or suicidal thoughts; or drug or alcohol addiction.

Tell your doctor if you are pregnant or breast-feeding.

The sedative effects of eszopiclone may be stronger in older adults. Accidental falls are common in elderly patients who take sedatives. Use caution to avoid falling or accidental injury while you are taking Lunesta.

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