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Indocin (Indomethacin)
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Indocin

Indocin is a much stronger medication than ibuprofen, which is why it can treat more severe pain. This doesn't mean it is always better, though. For example, some conditions, such as fevers, headaches, and menstrual cramps, are much better treated by ibuprofen. Talk with your healthcare provider first to decide which is best for you.

Other names for this medication:
Artid, Artisid, Donica, Ducain, Edcin, Idicin, Indmecin, Indoc, Indocap, Indocid, Indoflam, Indol, Indomethacin, Indonet, Indopar, Indoriv, Inmecin, Inocin, Methadocin, Microcid, Recticin, Tissop

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Zanaflex, Zocor, Prandin, Danocrine, Amoxil, Goritel, Benalapril, Gestatron, Cipromide, Donrid, Rocaltrol,

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Also known as: Indomethacin

Description

Indocin SR is a nonsteroidal anti-inflammatory drug (NSAID).

Indocin SR is used to treat moderate to severe osteoarthritis, rheumatoid arthritis, gouty arthritis, or ankylosing spondylitis. This medicine is also used to treat shoulder pain caused by bursitis or tendinitis.

Extended-release Indocin SR (Indocin SR) should not be used to treat gouty arthritis.

Dosage

This section provides information on the proper use of a number of products that contain indomethacin. It may not be specific to Indocin. Please read with care.

For safe and effective use of this medicine, do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. Using too much of this medicine may increase the chance of unwanted effects.

This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

When used for severe or continuing arthritis, this medicine must be used regularly as ordered by your doctor in order for it to help you. This medicine usually begins to work within one week, but in severe cases up to two weeks or even longer may pass before you begin to feel better. Also, several weeks may pass before you feel the full effects of this medicine.

Do not take rectal suppositories by mouth or use it in the vagina.

To use the suppository:

If the suppository is too soft to insert, chill it in the refrigerator for 30 minutes or run cold water over it before removing the foil wrapper. Remove the foil wrapper and moisten the suppository with cold water. Lie down on your side and use your finger to push the suppository well up into the rectum Remain lying down for about 15 minutes to keep the suppository from coming out before it melts. Make sure to wash your hands with soap and water before and after inserting this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For rectal dosage form (suppositories): For moderate to severe ankylosing spondylitis, osteoarthritis, or rheumatoid arthritis: Adults and children older than 14 years of age—One 50-milligram (mg) suppository, inserted into the rectum up to 3 times a day. Children up to 14 years of age—Use and dose must be determined by your doctor. For acute painful shoulder caused by bursitis or tendinitis: Adults and children older than 14 years of age—One suppository inserted into the rectum 3 to 4 times a day. Children up to 14 years of age—Use and dose must be determined by your doctor. For gout: Adults and children older than 14 years of age—One suppository inserted into the rectum 3 times a day. Children up to 14 years of age—Use and dose must be determined by your doctor.

Overdose

If you overdose Indocin and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Indocin overdosage: vomiting, migraine, lightheadedness, confusion, extreme tiredness, feeling of numbness, pricking, burning, creeping on the skin, convulsions, dyspepsia.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Indocin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Indocin can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Indocin may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using this medicine, especially in older adults.

You should not use Indocin if you are allergic to it, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.

Tell your doctor if you have ever had:

heart disease, high blood pressure; a heart attack, stroke, or blood clot; fluid retention; bleeding problems; stomach ulcers or bleeding; asthma; liver or kidney disease; or if you smoke.

If you are pregnant, you should not take Indocin unless your doctor tells you to. Taking an NSAID during the last 20 weeks of pregnancy can cause serious heart or kidney problems in the unborn baby and possible complications with your pregnancy.

This medicine may temporarily affect fertility (ability to have children) in women.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Indocin is not approved for use by anyone younger than 14 years old.

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In the present study, we ascertained that 2-aminopteridin-4(3H)-one, abbreviated as Ptr, is readily incorporated into and/or onto cervical cancer cells (HeLa) and that these cells die upon UV-A irradiation of Ptr. The rest of the population consisted of enteric bacteria with different characteristics and metabolic capabilities potentially related to biocorrosion. Machupo, Guanarito, Junin and Sabia viruses are New World haemorrhagic fever viruses that do not use alpha-dystroglycan. An efficient parallel algorithm for shortest paths in planar layered digraphs. cDNA cloning of the developmentally regulated lamin LIII of Xenopus laevis. Treating peripheral nerve endothelial monolayers with lovastatin significantly inhibited the in vitro migration of autoreactive splenocytes. I show that riders that performed better were more attractive, and that this preference was strongest in women not using a hormonal contraceptive. Severe oral lesions in chickens caused by ingestion of dietary fusariotoxin T-2.

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Working in psychiatry in New Zealand: Experiences of International (non-New Zealand) Medical Graduates. Basin-wide distribution of land use and human population: stream order modeling and river basin classification in Japan. Polyriboinosinic:polyribocytidylic acid enhances rabbit slow-wave sleep. Therefore, this study aims to evaluate correlation of different pattern of HOST with sperm parameters, protamine deficiency and apoptosis. The abnormal cartilage is characterized by an accumulation of proliferating chondrocytes and reduced maturation. Transforming growth factor-beta1 (TGF-beta1) regulates matrix production, and induces fibrosis in a variety of tissues.

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In vitro characterization of aldosterone and cAMP effects in mouse distal convoluted tubule cells. A microelectrochemical pH-stat with an automatic feedback function was fabricated. Screening processed milk for volatile organic compounds using vacuum distillation/gas chromatography/mass spectrometry. Based on current evidence, we provide a network view of relations between ZBTB16 and hallmarks of metabolic syndrome in order to elucidate the potential functional links involving the ZBTB16 node. Microwave-assisted syntheses of nucleosides and their precursors. In 105 fetuses with normal lung development who were assessed at 19 to 40 weeks of gestation, MR delineation of left and right lung organs was performed on the T2-weighted images with TE of 31 ms and extrapolated to the images with echo time (TE) of 267 ms. Verification of misacylated tRNAphe is apparently carried out only by phenylalanyl-tRNA synthetase. Cyclooxygenase II (COX-2) has an important function in biological processes such as cell proliferation and inflammation.

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To evaluate progression of arteriosclerosis using cardio-ankle vascular index(CAVI) and carotid duplex ultrasonography(DUS) in young and adolescent patients considered to be at risk of cardiovascular disease. The obtained results indicated that in short-term regulation of adiponectin secretion, insulin and epinephrine exert the opposite effects. All cases with a principal or secondary diagnosis of varicella hospitalized in Quebec between April 1, 1994 and March 31, 1996. In this single end design, only the main testing-end will be involved. The data are discussed in terms of the potential threat rural concentrations of NO(2) pose to crops and natural vegetation.

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The results related to the modeling capability show that there are differences between the one-dimensional (1-D) and the multidimensional versions of CMAC. However, long-term follow up studies are needed to solve issues related to its safety in pregnancy. Data were analyzed from a trial where 209 children were provided with adequate complementary food and followed fortnightly from 6-18 months of age. In this study, we performed microRNA (miRNA) profiling assays to study the potential roles of miRNAs in IPMNs using 78 cases of IPMN patients and controls. Screening of compounds that bound the modeled PfHDP structure in the heme/hemoglobin-binding pockets from Maybridge Screening Collection identified a compound, ML-2, that inhibited parasite growth in a dose-dependent manner, thus paving the way for testing its potential as a new drug candidate. Herein, we describe the use of non-viral gene transfer by cell-permeable peptide (CPP) to increase the transfection efficiency. There is no evidence in this large population-based cohort that SRIs protect against all-cause mortality or seizure-specific mortality. Properties of publications on anatomy in medical education literature. Expression of aldehyde dehydrogenase 6 reduces inhibitory effect of furan derivatives on cell growth and ethanol production in Saccharomyces cerevisiae. The P3 protein encoded by Shallot yellow stripe virus onion isolate (SYSV-O) interacted in the Yeast Two-hybrid (Y2H) system and in co-immunoprecipitation (Co-IP) assays with the large subunit of the ribulose-1,5-bisphosphate carboxylase/oxygenase (RubisCO) protein that is encoded by the rbcL gene of its onion host.

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The aim of this study was to characterize trastuzumab population pharmacokinetics (PKs) in patients with human epidermal growth factor receptor 2-positive advanced gastric or gastroesophageal junction cancer and the relationship of trastuzumab PK with patient response. The purpose of this paper is to integrate results of basic and clinical research with stimulants in order to enhance understanding of the neuropharmacological mechanisms of therapeutic action of these drugs. We extended these studies to investigate the role of nutrition and obesity in susceptibility to C. We show that Notch signalling induces Pou3f1 in developing motor neurons in vitro and in vivo. This research offers a new approach for the fabrication of continuous, strong, and uniform twisted nanofibers which could show promise in developing a novel carbon fiber precursor.

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Pancreatic function testing in meconium disease in cystic fibrosis. Association of urinary injury biomarkers with mortality and cardiovascular events. They can be employed in minority genetics investigation, individual and paternity test in forensic medicine. Ploidy, lymph node metastasis, and other classical parameters were analyzed in relation to the length of glucophage tablet disease-specific survival. Functional analysis suggests that several groups of lncRNAs may participate in biological pathways related to endometriosis by cis- and/or trans-regulation of protein-coding genes. Some ipRGCs differ not only functionally but also developmentally from RGCs that mediate pattern-forming vision.

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Glutamine is an important fuel for rapidly dividing cells such as enterocytes and lymphocytes. In this paper, we investigate a joint modeling approach, where the binary clinical outcome is modeled using a logistic regression model with the unobserved true functional biomarkers as the predictors. Our results indicate that specific recombinant DNA probes might provide tools for routine diagnosis and classification in cases of hardjo infections. A newly developed converter transforms the data of an electromagnetic locator into that of an optical sensor. The objective of this study was to compare the effectiveness of midpalatal implants with that of headgear as methods of supplementing anchorage during orthodontic treatment. A dynamic, optimal disease control model for foot-and-mouth disease: I. Ornithine transcarbamylase deficiency in a boy with long survival. These findings will inform an intervention program designed to increase immunization coverage among rural seniors in Vermont.

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These data suggest that collagenolytic activity in women with SUI is elevated compared to continent controls, as measured by urinary helical peptide alpha1 (I) 620-633 excretion. Insertion of these residues rendered the Galphat/i chimera with the ability to bind PDE gamma-subunit and stimulate PDE activity approaching that of native Galphat. Among all factors evaluated in the global geriatric assessment the baseline functional status was the strongest predictor for in-hospital mortality on this population. We have sought to identify transcriptional pathways in adipogenesis using an integrated experimental and computational approach. In accord with a centrosymmetric structure, the phases of the structure-factor triplets of two CDW reflections and a Bragg reflection of the host structure were determined to be either 0 or 180 degrees, and not to vary with temperature. Increased expression of Angiopoietin-2 and Angiopoietin-2 mRNA was associated with tumor dedifferentiation. Nonpalpable breast lesions: correlation calcitriol medication alternative of the BI-RADS classification and histologic findings. Marked overexpression of Tbx3 in a subset of hepatoblastomas is associated with chemotherapy-resistant phenotype and unfavorable patient outcome. We estimated multivariable odds ratios for mortality and postnatal HIV transmission for each biomarker using logistic regression. In the present study, we selected 300 specific pathogen free embryonated eggs, which were injected with subgroup B avian leukosis virus (ALV-B) and Bordetella avium (B.

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Over the last 20 years, multiple interventions to better integrate palliative care and intensive care unit (ICU) care have been evaluated. Loss of function of the miR-200 family phenocopies the terminal differentiation defect observed in absence of all miRNA activity in olfactory progenitors. Because stabilization of telomere length is also thought to be a necessary step in immortalization, telomerase activity, expression of the telomerase RNA component (hTR) and telomere length were anlaysed at various passages during the spontaneous immortalization of LFS skin fibroblasts. Results showed significant, strong support for behavioral flexibility and sex effects and weak support for the effects of sex-congruent tasks. Scanning electron microscopy study of the peritoneum as a dialysis membrane--a morphological study on the etiology of sclerosing peritonitis. In this article, we demonstrate spatially controlled gene delivery from tab singulair doses a substrate for directing cellular processes. The individual steps of these procedures are under software control and can be adjusted independently.

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