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Cooltime (Alprazolam)

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Cooltime is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder. It's also used in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Cooltime, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Cooltime is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Acalm, Alamflu, Alparazole, Alpraday, Alprazan, Alzin, Alzoact, Alzopam, Alzoset, Alzotime, Ambusyn, Anzal, Anzocalm, Ateez, Avizolem, Cozac, Fledore, Mebasap, Mebaspa, Morecalm, Nucalm, Pecalm, Pifzot, Prosanti, Restam, Restyl, Serex, Somnia, Tagat, Tancalm, Tenfree, Tensfree, Trapose, Zallpam, Zolin, Zorest, Zotam

Similar Products:
Avodart, Cytoxan, Aurogra, Rogaine, Aricept, Teemvork, Asacol, Carebet, Alangel, Alprocalm, Dilzem, Cynopryl, Lormeg,

Also known as: Alprazolam


Cooltime (alprazolam) is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). It is thought that alprazolam works by enhancing the activity of certain neurotransmitters in the brain.

Cooltime is used to treat anxiety disorders and anxiety caused by depression.

Cooltime is also used to treat panic disorders with or without a fear of places and situations that might cause panic, helplessness, or embarrassment (agoraphobia).

It is dangerous to purchase Cooltime on the Internet or outside the United States. The sale and distribution of medicines outside the U.S. does not comply with safe-use regulations of the Food and Drug Administration (FDA). These medications may contain dangerous ingredients, or may not be distributed by a licensed pharmacy.


Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results.

Do not crush, chew, or break an extended-release tablet. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking the pill would cause too much of the drug to be released at one time.

Measure the liquid form of Cooltime with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Do not swallow the orally disintegrating tablets whole. Allow it to dissolve in your mouth without chewing.

Contact your doctor if this medicine seems to stop working as well in treating your panic or anxiety symptoms.

You may have seizures or withdrawal symptoms when you stop using Cooltime. Ask your doctor how to avoid withdrawal symptoms when you stop using Cooltime.

Keep track of the amount of medicine used from each new bottle. Cooltime is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.


Seek emergency medical attention if you think you have used too much of this medicine. An overdose of Cooltime XR can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, fainting, and coma.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is very important to protect the orally disintegrating tablets from moisture. Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine.

Detailed Cooltime XR dosage information

Side effects

The most common side effects associated with Cooltime are:

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The data presented here provide insight into the toxicologic effects gold nanoparticles elicit on ovarian granulosa cells. Incidence and consequences of falls among elderly people living in the community. A technique was developed to produce small intestinal mucosal injury in vivo by perfusing the mid-small intestine of rats with HCl, NaOH, FeSO4, and AgNO3. Three current problems of contemporary mental hygiene: old age, automation, epilepsy. Adipose tissue distribution and risk of metabolic disease: does thiazolidinedione-induced adipose tissue redistribution provide a clue to the answer?. With respect to the resting membrane properties La mimicked the action of Ba and of altered K concentrations, both of which are known to exert their effects mainly by changing the K permeability.

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Method of hologram multiplexing by use of a fiber bundle with rotary movement. Decompression sickness that RESULTS in formation of bubbles of inert gas is a risk for both aviators and divers. Multidipole analysis of simulated epileptic spikes with real background activity. A total of 53 patients with head and neck cancer entered this prospective randomized study. Competence repression under oxygen limitation through the two-component MicAB signal-transducing system in Streptococcus pneumoniae and involvement of the PAS domain of MicB. Hibernation in freshwater turtles: softshell turtles (Apalone spinifera) are the most intolerant of anoxia among North American species. First- and second-year orthopedic surgery residents from the University of Calgary were consented, surveyed for their arthroscopy experience and randomized to either cadaver or composite teaching. This newer regimen achieves a higher and almost complete seroconversion rate, although frequent boosters shots are necessary to maintain protective levels. CT established that is a profound lymphangioma with a narrow communication with the superficial planes.

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Reciprocal activity of longitudinal and circular muscle during intestinal peristaltic reflex. The analytical results compare favorably with the results of direct numerical simulation of the full system. Two peaks, belonging to the beta-globulin fraction, were found to be remarkably retarded in the buffer containing MerES-Gen in a concentration-dependent way. The displacement occurred in a time-dependent fashion, and, without redress, significant dosimetric changes are encountered by the third fraction. Beractant and calfactant were similar in terms of efficacy, safety, and total number of doses per patient. Intense inflammation and progressive disappearance of typical histologic structures of the aorta were seen within the first 3 months. Monitoring of iron parameters and a large use of iron supplementation result in an efficient epoetin response. Neuropsychiatric deficits in individuals with VCFS seem to follow a developmental pattern. Glucosamine mimicked the stimulatory effects of high glucose on JNK and ERK1/2 activity and IRS-1 phosphorylation at Ser(307) and Ser(612). The tolerance of SLE patients to radiotherapy can thus be achieved by proper delivery of radiation and the sparing of normal tissues by IMRT although further confirmatory studies are required.

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The first model is clonal, the second is sexual diploid with additive genetics on a single locus and the third is like the second but with an additional locus for mate choice. The role of Dicer has previously been established in RNAi as the originator of 22-mers characteristic of silencing phenomena. Complications following vertebral manipulation-a survey of a French region physicians. The authors report a case of wave burst arrhythmia in a young immigrant woman of Laotian origin aged 32. Response was defined as the total duration of visual fixation in each trial. Because of the indications for liver damage due to nitrofurantoin, the drug was discontinued immediately on admission. Food consumption and growth rate declined with increased temperature, and there was a significant increase in fat, and a decrease in water content of the carcasses. Chemosensitivity testing, based on the MTT assay, was useful in evaluating the appropriate cancer chemotherapy for patients with Stages III/IV gastric cancer without peritoneal dissemination.

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This report describes the dental management and 7-year follow-up of a 14-year-old boy who showed the typical characteristics of Lenz microphthalmia syndrome, a rare genetic disorder characterized by multiple abnormalities. This study could help to shape and unify the future provision of clinical supervision. Redesigning the care of rheumatic diseases at the practice and system levels. Use of a human patient simulator in the development of resident trauma management skills. The orbital lymphoma was angiodestructive with prominent necrosis and frequent apoptosis.

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If this preventive measure is effective, the incidence of illness should be lower and the cost reduced. Comparison of five experimental pain tests to measure analgesic effects of alfentanil. Column robustness case study for a liquid chromatographic method validated in compliance with ICH, VICH, and GMP guidelines. These studies show a paraendothelial mechanism by which endostatin can inhibit peritoneal dissemination of ovarian cancer cells and raises the possibility of intraperitoneal expression of endostatin to atenolol brand name in bangladesh reduce recurrence. The aim of this study was to compare potential functional differences of 12 rearranged (rr)-NCCR variants with the archetype (ww)-NCCR (WWT) found in allograft biopsies or urine from three kidney transplant recipients including two with BKV-nephropathy. Survival was evaluated using the Kaplan-Meier method and comparison of survival curves by log-rank test. This common menopausal condition, which is often underreported and underdiagnosed, is caused by estrogen-related changes to the vaginal epithelium and can adversely affect quality of life. Unlike the rat, apomorphine-induced PPI disruption in mice might be instrumental in distinguishing between typical and atypical antipsychotic drugs. Collectively, these results show that maintenance of T cell responses in the virus-infected CNS is a dynamic process.

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We studied the expression of myelin basic protein (MBP), a major component of central nervous system myelin, in peri-infarct areas in adult rat brain after transient middle cerebral artery occlusion (MCAO) and correlated it to the expression of the growth-associated protein-43 (GAP-43), a marker for axonal regeneration and sprouting, using non-radioactive in situ hybridization techniques. The effect of publication on Internet-based solicitation of personal-injury litigants. A total of 93 million admissions from the National Inpatient Sample (NIS) file from the years 1988-1996, 1998, 1999, 2001, 2002, 2004-2005 and the Kids Inpatient Database (KID) from 1997, 2000, 2003 were screened to identify surgical admissions in children under the age ezetimibe zetia tablet 10 mg cost of 18 years. Transcription in the dorsal pontine tegmentum was found to be necessary to maintain the long lasting bladder overactivity caused by cerebral infarction. In view of the results, two of the two-carrier models discussed in paper I (Eilam, Y. Theoreticians have proposed that gravitational effects could come about from the bifurcation properties of certain types of non-linear chemical reactions that self-organise by reaction and diffusion. Previously, we reported the isolation of the major lethal protein toxins, PsTX-60A and PsTX-60B, from P. The measles vaccine given intranasally was used in the same or double dose. The motor latency returned to normal, and no fibrillations nor positive waves were seen.

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Role of protein kinase C activity in tumor necrosis factor-alpha gene expression. pombe will benefit further studies in drug screening model and host searching for heterologous gene expression. The evanescent field generated under total internal reflection at the pavilion facet was exploited for ATR spectral acquisition of materials attached to the IRE. The aims were to test relationships between bulimic eating disorder behaviors, and measures of quality of life, and to replicate previous findings with respect to their prevalence and distribution in a representative sample. Left-right asymmetric signaling molecules in mammals include three transforming growth factor beta (TGFbeta)-related factors, Nodal, Lefty1 and Lefty2. Regeneration of periodontal structures lost during periodontal diseases constitutes a complex biological process regulated among others by interactions between cells and growth factors. Bornholm Disease in South-east England: A Faculty investigation into the Occurrence and Spread of the Disease in South-east England during the Autumn of 1956. GRIP1 and Zac1 might selectively function with HPV E2 proteins on thyroid receptor- and p53-dependent transcriptional activation, respectively.

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Nanotube surface arrays: weaving, bending, and assembling on patterned silicon. Atopic eczema was associated with a lower risk of type 1 diabetes, independent of a number of candidate risk factors, suggesting that it may confer partial protection against type 1 diabetes. A carefully regulated balance between activation and inhibition must be kept to avoid detrimental and inappropriate inflammatory responses. Autopsy has been shown to reduce albenza dosing pinworm the rate of severe medical errors and thus is an important tool for the quality control. PhoU was found to interact with neither PhoB nor PhoR, while this acted as a phosphate starvation-inducible protein. The clustering adds an extra level of complexity to the study design. A conclusive assignment of the fucosylation site of the studied glycan structure has been facilitated through measurement of cross-ring fragmentation resulting from photodissociation. This change predisposes a diabetic patient to various thrombo-embolic conditions, leading to increased mortality and morbidity of these patients.

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To determine clinical predictors of hypoxemia in children with acute lower respiratory tract infection (ALRI). Cryopreservation-Thawing of fractionated human spermatozoa is associated with membrane phosphatidylserine externalization and not DNA fragmentation. Following the initial treatment, hyperreflexia and convulsions did not recur. In fact, it was the older women in the randomised trials that failed to show benefit, whereas there was a trend to benefit in the younger ones for whom the starting dose of HRT was appropriate. Water deprived rats were trained to drink from a water spout within an apparatus on each of 2 days. The concentrations of endogenous amino acids and choline in the extracellular fluid of human cerebral gliomas have been measured, for the first time, by in vivo microdialysis. A total of 1,227 stable schizophrenic patients within 5 years onset who took 1 of the 7 study medications as maintenance treatment were followed up for 1 year at 10 China sites.

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However, with these strategies, an increased tumor control rate is often accompanied by more severe side effects. Activation of the Snf1 kinase requires at least two events, phosphorylation of the activation loop on threonine 210 and an Snf4-dependent process that is not completely defined. While some neuroanatomical and neuropsychological studies have reported existence of differences between male and female patients in a direction of normal sexual dimorphism, others did not find any effect. The observed failure pattern after FET-PET planning and chemo-RT is primarily central. All these lesions were prevented by raising the dietary magnesium level four to eight times. A 38-year-old layer of parquet flooring was referred because of memory impairment, tiredness and diffuse headaches. Safety, immunogenicity, and protective efficacy of two doses of RIX4414 live attenuated human rotavirus vaccine in healthy infants. Elevation of systemic BP in hyperthyroidism resultant from oxidation-phosphorylation uncoupling, leading to decrease of ATP production by mitochondria, is an example of energy dependence of the hypertension prilosec dosage time phenomenon. The preparation of large quantities of purified membrane proteins for structural studies presents significant difficulties. Tectal polarity for retinal connections remains reversible long after the anatomical pattern of neural structures has been determined.

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GATA-1 is the key transcription factor for the development of the erythroid, megakaryocytic, eosinophilic, and mast cell lineages. Canine rotavirus was isolated in MA104 roller culture of rhesus macaque cells. Epicardial fat thickness was significantly correlated with the severity of coronary artery disease in patients with known coronary artery disease. Patients were assessed using a standard questionnaire, clinical examination of spinal movements, plain radiology of the sacroiliac joints, computerised tomographic scanning of the sacroiliac joints and HLA-B27 typing. An outcome evaluation of the implementation of the Triple P-Positive Parenting Program in Hong Kong. The density-gradient pattern is not related to runoff during preparation. Some thoughts are offered on the role of the journal in making developments in these areas more accessible to psychologists.

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To investigate the effectiveness of a computer monitoring system that detects adverse drug reactions (ADRs) by laboratory signals in gastroenterology. Emergence of delinquency and depressed mood throughout adolescence as predictors of late adolescent problem substance use. Sharp reductions in urinary chloride and sodium concentrations observed in conjunction with these blood flow shifts may be a reflection of the relatively greater perfusion of juxtamedullary nephrons, which are alleged to have greater salt-retaining characteristics than their outer cortical counterparts. The resulting transfectants are highly stable both in terms of T cell receptor-CD3 expression and IL-2 response to the specific antigenic stimulus. Other rats received both drugs (haloperidol 30 min after alphaMT). At vessel analysis, the intima-media thickness, the property of plaque and stenotic ratio are evaluated.

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