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Bexomer (Eszopiclone)

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Bexomer is a sedative medication. It affects chemicals in human brain that may become unbalanced and cause sleep problems (insomnia). Bexomer is used to treat insomnia: it causes relaxation to help you fall asleep and stay asleep. EsBexomer may also be used for purposes other than those listed here.

Other names for this medication:
Bexomer, Eszopiclone, Fulnite, Zolnite, Zopimin, Zopipure

Similar Products:
Valtrex, Micardis, Hytrin, Mestinon, Catapres, Biaxin, Dostinex, Diflucan, Dilcor, Nifedin, Estal, Ismorin, Promacot,

Also known as: Eszopiclone


Bexomer along with other Z-drugs are the most commonly prescribed sedative hypnotics in the United States. Eszopiclone is not marketed in the European Union following a 2009 decision by the EMA denying it new active substance status, in which it ruled that eszopiclone was too similar to zopiclone to be considered a new patentable product. Eszopiclone is now available in a generic form in the United States as of May 2014. On May 15, 2014, the USFDA asked that the starting dose of Bexomer be lowered from 2 milligrams to 1 milligram after it was observed in a study that even 8 hours after taking the drug at night, some patients were not able to cope with their next-day activities like driving and other activities that require full alertness. It works by interacting with the GABA receptors.

Bexomer is slightly effective in the treatment of insomnia where difficulty in falling asleep is the primary complaint. Kirsch et al. found the benefit over placebo to be of questionable clinical significance. Although the drug effect and the placebo response were rather small and of questionable clinical importance, the two together produce a reasonably large clinical response. It is not recommended for chronic use in the elderly.


Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Take Bexomer only if you are able to get a full night's sleep before you must be active again. Never take this medication during your normal waking hours, unless you have at least 8 hours to dedicate to sleeping.

Take Bexomer with a full glass of water.

Avoid taking Bexomer within 1 hour after eating a high-fat or heavy meal. This will make it harder for your body to absorb the medication.

Bexomer is for short-term use only. Tell your doctor if your insomnia symptoms do not improve, or if they get worse after using this medication for 7 to 10 nights in a row. Do not take Bexomer for longer than 2 weeks without your doctor's advice.

You may have withdrawal symptoms if you stop taking Bexomer after taking it over several days in a row. Do not stop taking Bexomer suddenly without first talking to your doctor. You may need to use less and less before you stop the medication completely.


In clinical trials with Bexomer, one case of overdose with up to 36 mg of Bexomer was reported in which the subject fully recovered. Since commercial marketing began, spontaneous cases of Bexomer overdoses up to 270 mg (90 times the maximum recommended dose of Bexomer) have been reported, in which patients have recovered. Fatalities related to Bexomer overdoses were reported only in combination with other CNS drugs or alcohol.

exaggerations of the pharmacological effects noted in preclinical testing. Impairment of consciousness ranging from somnolence to coma has been described. Rare individual instances of fatal outcomes following overdose with racemic zopiclone have been reported in European postmarketing reports, most often associated with overdose with other CNS-depressant agents.

General symptomatic and supportive measures should be used along with immediate gastric lavage where appropriate. Intravenous fluids should be administered as needed. Flumazenil may be useful. As in all cases of drug overdose, respiration, pulse, blood pressure, and other appropriate signs should be monitored and general supportive measures employed. Hypotension and CNS depression should be monitored and treated by appropriate medical intervention. The value of dialysis in the treatment of overdosage has not been determined.

As with the management of all overdosage, the possibility of multiple drug ingestion should be considered. The physician may wish to consider contacting a poison control center for up-to-date information on the management of hypnotic drug product overdosage.


Store Bexomer at room temperature away from moisture and heat.

Keep track of how many capsules have been used from each new bottle of this medicine. Bexomer is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.

Side effects

The most common side effects associated with Bexomer are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


There is an increased risk of increased central nervous system depression when it is used with eszopicolone including anti-psychotics, sedative/hypnotics, antihistamines, opioids, and antidepressants. There is also increased risk of increased risk of central nervous system depression with other medications that inhibit the metabolic activities of the CYP3A4 enzyme system of the liver. Medications that inhibit this enzyme system include nelfinavir, ritonavir, ketoconazole, itraconazole and clarithromycin. Alcohol also has an additive effect when used concurrently with eszopicolone. Eszopicolone is most effective if it is not taken after a heavy meal with high fat content.

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Despite the theoretical benefits, angiotensin II type 1 receptor antagonists seem to enhance rather than reduce morbidity and mortality after myocardial infarction compared with angiotensin-converting enzyme inhibitors. However, in the in vitro setting, complex enzyme kinetics can alter the estimation of kinetic parameters. Even though only a small set of compounds has been designed, the activity immediately matches that of the original peptides, supporting the proposed criteria for activity, i.e. Pediatric stroke survivors compared with healthy controls are strongly affected regarding their overall well-being and older children/adolescents regarding their well-being with peers. Dysregulation of pulmonary elastin synthesis and assembly in preterm lambs with chronic lung disease. Chronic undernutrition significantly increased life span and increased somato-motor competence but did not affect sensory function or sensory-motor integrity. In a longitudinal design, 2333 participants completed a survey on night time and daytime symptoms, and cognitive processes. Prognostic value of immunologic determinations of chorionic gonadotropins (C.G.H.) in treatened abortion. Here, I present a modelling-based approach to identify genetic mutations in developmental patterning that may affect the transient, but leave invariant the steady-state signalling gradient.

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Bovine serum albumin (BSA) surface-imprinted submicrometer particles (500-600 nm) with magnetic susceptibility were prepared through a two-stage core-shell miniemulsion polymerization system using methyl methacrylate and ethylene glycol dimethacrylate as functional and cross-linking monomers, respectively. BACKGROUND: A number of reports indicate that circulating immune complexes (CIC) and activation of the complement system contribute to the pathogenesis of Type I allergy. Two-photon holographic recording in aluminosilicate glass containing silver particles. Twelve guinea-pigs (300-400 g initial weight) were kept in individual metabolic cages at 22 degrees C during weeks 1 and 5. A 26-year-old male patient presented with left-sided facial swelling and nasal obstruction that had a history of six months. Evaluation of destruction in a collagen-induced arthritis rat model: Bony spur formation. A double-blind study of the effect of carbenoxolone sodium in the treatment of gastric ulcer.

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Transient blockade of the CD11d/CD18 integrin reduces secondary damage after spinal cord injury, improving sensory, autonomic, and motor function. Results of a clinical test on the oral antidiabetic agent glibornuride (Ro 6-4563). Sulforhodamine B and colony-forming experiments indicated that CUS inhibited PANC-1 cell proliferation in a dose- and time-dependent manner. A significant interaction between diagnosis and disease duration was also revealed. The chromosomes with shortened telomeres tend to become unstable, leading to cell death. Favorable DNA index was associated with a better prognosis in IR and HR patients defined by presenting clinical criteria and treatment with a BFM-oriented chemotherapy. DNA breakage was maximal by 1 h after verapamil iv dose atrial fibrillation exposure, and rapidly declined to control levels by 8 h. Due to this specific glioneuronal element, the diagnosis of DNT was retained. Medicare reimbursement rules for clinical laboratory procedures are explained, including the proper use of procedure and diagnosis codes.

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Anxiety-like behaviour was assessed using elevated-plus maze task. Together with other data it is suggested that the short implantation period in M. A nationwide incidence survey of Kawasaki disease in 1985-1986 in Japan. In the recent few years, whole genome shotgun (WGS) sequencing of environmental DNA (metagenomics) has revolutionized the field of environmental microbiology by allowing one to tap into the genomic content of microbial communities in specific ecological niches, deducing information on their biochemical potentials. This period of enhanced glutamate release into the parabrachial nucleus corresponded to a time during which the pressor response to a bolus phenylephrine injection was significantly enhanced, and the reflex bradycardia was attenuated. The collagen organization increases from unordered woven bone in the callus which is gradually replaced by higher ordered lamellar bone during bone development and healing and finally results in cortical lamellar bone with highest degree of organization. Increased urinary excretion of digoxin-like immunoreactive substance by insulin-dependent diabetic patients: a linkage with hypertension?. Nodularin was also detected in the reproductive part of the algae (receptacle) at 14.1 microg kg(-1) fw. AAV1-based vectors encoding GDNF or vectors encoding GDNF with an rtTA2s-S2 Tet-on regulation system were directly microinjected into the rat cochleae through the round window at 5 x 10(10) genome copies/body. sabulosa and its EA induced an increase in the percentage of time spent on, and in the frequency of entries into the open arms, as well as in the number of unprotected head-dipping, besides a reduction in protected stretch-attend postures, thus indicating an anxiolytic-like profile of action for this plant species.

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The variant course of the facial nerve within the parotid may endanger the nerve during parotid surgeries. The widespread occurrence of free-ranging domestic or feral carnivores (dogs, cats) or ungulates (pigs, goats), and massive releases of captive-reproduced game stocks (galliforms, waterfowl) is raising fear that introgressive hybridization with wild populations might disrupt local adaptations, leading to population decline and loss of biodiversity. thermophilus and Escherichia coli RF2 by microcalorimetry, circular dichroism spectroscopy and small angle X-ray scattering. Systemic lupus erythematosus, radiotherapy, and the risk of acute and chronic toxicity: the Mayo Clinic Experience. Many horizontally acquired genes (xenogenes) in the bacterium Escherichia coli are maintained in a silent transcriptional state by the nucleoid-associated transcription regulatory protein H-NS. Concurrent rupture of the rotator cuff and anterior dislocation of the shoulder in the older patient.

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Pulmonary function test results were obtained from medical charts. Such dietary oxidative stress also allows a normally benign (i.e., amyocarditic) coxsackievirus B3 to convert to virulence and cause heart damage. The diagnosis of these diseases, including aromatic L-amino-acid decarboxylase (AADC) deficiency, typically requires cerebrospinal fluid (CSF) neurotransmitter analysis. Studies involving music interventions in the field of obstetrics have shown, amongst other things, that music improves the ability to relax during pregnancy and can reduce anxiety. Scaling behavior of oscillations arising in delay-coupled optoelectronic oscillators. These alterations can be used as candidate targets in molecular tests for risk, early detection, prognosis, prediction of response to therapy, and monitoring, as well as new therapeutic targets in cancer. Mutation in ROBO3 gene recently demonstrated in patients with horizontal gaze palsy with progressive scoliosis.

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The end result of target gene transcription is to modulate physiological processes, such as reproductive organ development and function, bone density, and unfortunately contribute to the growth and development of breast and endometrial cancer. The mechanism of action of a relatively new antipsychotic drug-Risperidone differs from conventional antipsychotics like Haloperidol. Complex healthcare regulation: managing the continued challenge of competence. Prenatal detection and postnatal management of double outlet right ventricle (DORV) in 21 singleton pregnancies. Then the dose should be adjusted to maintain the aPTTX2-2.5 pre-treatment value. Lateral cephalometric films, peri-apical radiographs, orthopantomographs and orthodontic casts of each subject were taken before and after treatment. This pattern of TPMT activity was highly correlated with expression of TPMT mRNA among strains, and high TPMT expression is dominant in F1 hybrids. In the bivariate analysis, only three chronic diseases - dementia, urinary incontinence, and chronic heart failure - showed a higher tramadol im dosage adults risk for nursing home care. The effect of liver denervation on the consumption of various diets by rats.

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