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Azuril (Roxithromycin)

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Azuril is a semi-synthetic macrolide antibiotic. It is a white crystalline powder. Azuril is very slightly soluble in water, freely soluble in acetone, in alcohol and in methylene chloride. It is slightly soluble in dilute hydrochloric acid.

Other names for this medication:
Acevor, Asmetic, Biaxsig, Bicofen, Cadithro, Claramid, Delos, Dorolid, Elrox, Floxid, Infectoroxit, Macrolid, Macrosil, Monobac, Nirox, Odonticina, Pedilid, Redotrin, Remora, Renicin, Ritosin, Rokilide, Roksimin, Rolexit, Rolid, Rotramin, Roxacine, Roxithromycinum, Roxitromicina, Rulid

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Also known as: Roxithromycin


Azuril is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. Azuril is derived from erythromycin, containing the same 14-membered lactone ring. However, an N-oxime side chain is attached to the lactone ring. It is also currently undergoing clinical trials for the treatment of male-pattern hair loss.

Azuril is available under several brandnames. Azuril is not available in the United States. Azuril is available in Australia, Israel and New Zealand. Azuril has also been tested to possess antimalarial activity.

Azuril prevents bacteria from growing, by interfering with their protein synthesis. Azuril binds to the subunit 50S of the bacterial ribosome, and thus inhibits the synthesis of peptides. Azuril has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila.


Azuril is typically prescribed for a period of 7 to 14 days and patients should take the medication for as long as it has been prescribed to prevent the infection from returning even if they become asymptomatic. Patients should not however, take doses larger than has been prescribed as this can result in an overdose. Overdosing requires immediate medical intervention and may present with symptoms which include abdominal pain, nausea, diarrhea, vomiting, and a general and prolonged feeling of illness.


Immediately telephone your doctor or pharmacist. Do this even if there are no signs of discomfort or poisoning.


Keep your tablets in the blister pack until it is time to take them. If you take the tablets out of the blister pack they may not keep well.

Keep the medicine in a cool, dry place where the temperature stays below 25 degrees C.

Do not store it or any other medicine in the bathroom, near a sink or on windowsill.

Do not leave it in the car. Heat and damp can destroy some medicines.

Keep it where children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.

Side effects

The most common side effects associated with Azuril are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


The safety of roxithromycin has not been demonstrated in patients with impaired hepatic or renal function. Caution should be exercised if roxithromycin is administered to patients with impaired hepatic or renal function. If administered to patients with severe impaired hepatic function (eg. hepatic cirrhosis with jaundice and/or ascites), consideration should be given to reducing the daily dosage to half the usual dosage.

Prolonged or repeated use of antibiotics including roxithromycin may result in superinfection by resistant organisms. In the event of superinfection, roxithromycin should be discontinued and appropriate therapy instituted.

When indicated, incision, drainage or other appropriate surgical procedures should be performed in conjunction with antibiotic therapy.

Antibiotic associated pseudomembranous colitis has been reported with many antibiotics. A toxin produced by Clostridium difficile appears to be the primary cause. The severity of the colitis may range from mild to life threatening. It is important to consider this diagnosis in patients who develop diarrhoea or colitis in association with antibiotic use (this may occur up to several weeks after cessation of antibiotic therapy). Mild cases usually respond to drug discontinuation alone. However, in moderate to severe cases, appropriate therapy with a suitable oral antibacterial agent effective against Clostridium difficile should be considered. Fluids, electrolytes and protein replacement therapy should be provided when indicated.

Roxithromycin, like erythromycin, has been shown in vitro to elicit a concentration - dependent lengthening in cardiac action potential duration. Such an effect is manifested only at supra – therapeutic concentrations. Accordingly, the recommended doses should not be exceeded. In certain conditions macrolides, including roxithromycin, have the potential to prolong the QT interval. Therefore roxithromycin should be used with caution in patients with congenital prolongation of the QT interval, with ongoing proarrhythmic conditions (ie uncorrected hypokalemia or hypomagnesaemia, clinically significant bradycardia), and in patients receiving Class IA and III antiarrhythmic agents.

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Comparison of the Q-fever complement fixation test and two commercial enzyme-linked immunosorbent assays for the detection of serum antibodies against Coxiella burnetti (Q-fever) in ruminants : recommendations for use of serological tests on imported animals in New Zealand. dsrD was transferred to and expressed in Lactococcus lactis MG1363. To obtain statistically valid data on the occurrence of this entity in the elderly, serial sections of the entire prostate obtained at 57 consecutive autopsies in males eighty years of age and over were analyzed. To evaluate the possibility of using the determination of beta-glucuronidase and phenylalanine deaminase activity directly from urine samples for rapid detection (2 hours) of the presence of Escherichia coli and species of the Proteeae tribe. The ratios of actual and predicted values of FEV1 were normally distributed in boys and girls. In vertebrates, both reactive oxygen species (ROS) and the corresponding scavenging system components depakote class drug especially glutathione peroxidase (GPx) are indispensible for normal development of the gonads. Primary therapy, directed toward the sepsis and pulmonary complications, was often unsuccessful until the associated osteomyelitis was recognized and treated.

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At 8 years of age, children in Calicut participating in the ICDS have greater birth weight and relative attenuation of the evolution of early CVD markers compared with children in apparently comparable states. In regard to stool behaviour both groups showed no differences, in the number of bowel movements or in the time to the first postoperative defecation. Differences among tested factors were tested by Wilcoxon rank sign test for paired data. Microdialysis and response during regional chemotherapy by isolated limb infusion of melphalan for limb malignancies. Firstly, we confirmed a single nucleotide alteration in the uidA gene (T93G), which is specific to E. For monogenic diabetes an understanding of these processes is aiding scientists and clinicians in studying and managing this disease. Skill acquisition and retention in automated external defibrillator (AED) use and CPR by lay responders: a prospective study.

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To test whether the angiotensin-converting enzyme inhibitor captopril was effective in mitigating chronic renal failure after hematopoietic stem cell transplantation (HSCT). This paper describes the method and presents a visual fMRI experiment as an example to demonstrate the results. Hospitals generally found ways to cope with duty hour reform without increasing the prevalence of prolonged hospital stays, a marker of either inefficient care or complications. Only five deletion mutations yielded lethal phenotypes, and these were colinear, spanning a 56-amino-acid region within domain II. Finally, when functionally monogynous and polygynous colonies were kept under identical laboratory conditions, social organization did not change, suggesting a genetic basis for the polymorphism.

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