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Asmetic (Roxithromycin)
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Asmetic

Asmetic is a semi-synthetic macrolide antibiotic. It is a white crystalline powder. Asmetic is very slightly soluble in water, freely soluble in acetone, in alcohol and in methylene chloride. It is slightly soluble in dilute hydrochloric acid.

Other names for this medication:
Acevor, Aristomycin, Asmetic, Assoral, Azuril, Bazuctril, Bicofen, Biostatik, Cadithro, Claramid, Crolix, Delos, Dorolid, Erybros, Floxid, Infectoroxit, Klomicina, Ladlid, Macrolid, Macrosil, Makrodex, Monobac, Nirox, Odonticina, Overal, Pedilid, Pedrox, Ramivan, Redotrin, Remora, Renicin, Ritosin, Rokilide, Rokithrid, Roksimin, Roksolit, Rolid, Rossitrol, Rotramin, Roxacine, Roxithromycin, Roxithromycine, Roxithromycinum, Roxitromicina, Rulid

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Also known as: Roxithromycin

Description

Asmetic is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. Asmetic is derived from erythromycin, containing the same 14-membered lactone ring. However, an N-oxime side chain is attached to the lactone ring. It is also currently undergoing clinical trials for the treatment of male-pattern hair loss.

Asmetic is available under several brandnames. Asmetic is not available in the United States. Asmetic is available in Australia, Israel and New Zealand. Asmetic has also been tested to possess antimalarial activity.

Asmetic prevents bacteria from growing, by interfering with their protein synthesis. Asmetic binds to the subunit 50S of the bacterial ribosome, and thus inhibits the synthesis of peptides. Asmetic has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila.

Dosage

Take Generic Asmetic by mouth with food. If you have trouble swallowing the tablet whole, it may be crushed or chewed with a little water. Swallow Generic Asmetic tablets whole with a glass of water. Generic Asmetic should be taken at least 15 minutes before food or on an empty stomach (i.e. more than 3 hours after a meal). Generic Asmetic works best if you take it on an empty stomach. For treating bacterial infections, Generic Asmetic is usually taken for 5 to 10 days. If you want to achieve most effective results do not stop taking Generic Asmetic suddenly.

Overdose

If you overdose Generic Asmetic and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture, light and heat. Do not store in the bathroom. Keep in a tight, light-resistant container. Keep out of the reach of children.

Side effects

The most common side effects associated with Asmetic are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

The safety of roxithromycin has not been demonstrated in patients with impaired hepatic or renal function. Caution should be exercised if roxithromycin is administered to patients with impaired hepatic or renal function. If administered to patients with severe impaired hepatic function (eg. hepatic cirrhosis with jaundice and/or ascites), consideration should be given to reducing the daily dosage to half the usual dosage.

Prolonged or repeated use of antibiotics including roxithromycin may result in superinfection by resistant organisms. In the event of superinfection, roxithromycin should be discontinued and appropriate therapy instituted.

When indicated, incision, drainage or other appropriate surgical procedures should be performed in conjunction with antibiotic therapy.

Antibiotic associated pseudomembranous colitis has been reported with many antibiotics. A toxin produced by Clostridium difficile appears to be the primary cause. The severity of the colitis may range from mild to life threatening. It is important to consider this diagnosis in patients who develop diarrhoea or colitis in association with antibiotic use (this may occur up to several weeks after cessation of antibiotic therapy). Mild cases usually respond to drug discontinuation alone. However, in moderate to severe cases, appropriate therapy with a suitable oral antibacterial agent effective against Clostridium difficile should be considered. Fluids, electrolytes and protein replacement therapy should be provided when indicated.

Roxithromycin, like erythromycin, has been shown in vitro to elicit a concentration - dependent lengthening in cardiac action potential duration. Such an effect is manifested only at supra – therapeutic concentrations. Accordingly, the recommended doses should not be exceeded. In certain conditions macrolides, including roxithromycin, have the potential to prolong the QT interval. Therefore roxithromycin should be used with caution in patients with congenital prolongation of the QT interval, with ongoing proarrhythmic conditions (ie uncorrected hypokalemia or hypomagnesaemia, clinically significant bradycardia), and in patients receiving Class IA and III antiarrhythmic agents.

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Pediatric methylphenidate exposures: 7-year experience of poison centers in the United States. Postgraduate Education of Physicians for Industrial Health Service. Endothelin-1 (ET-1) is a potent endothelial-derived 21-amino-acid vasoconstrictor peptide and its expression is potently regulated by the cytokine transforming growth factor-beta (TGF-beta). The involvement of insulin/IGF-1 signals and leptin signals in spinal ligament cells was investigated using Zucker fatty rats (fa/fa) that carry mutation of the leptin receptor gene (fa) and monosodium glutamate-treated (MSG) rats that present obesity due to destruction of the hypothalamic ventromedial nucleus. We show first that the nucleo-cytoplasmic ratio and then, that the volume fraction of intercellular spaces, nuclei and cytoplasm as they relate to the neural tube, differ significatively from cephalic to caudal portion of the neural tube. Concentrations of ammonia and hydrogen sulfide in the pig buildings averaged 7.5ppm and 286.5ppb and ranged from 0.8 to 21.4ppm and from 45.8 to 1235ppb, respectively. Major discrimination was related to the signal from phosphate-containing compounds, likely phospholipids. Curcumin attenuates left ventricular dysfunction and remodeling in rabbits with chronic heart failure. One of these patients, who suffered from severe adipositas, died. The articles relevant to this topic, published during this 2 year time period, are considered as organized by anatomic region.

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