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Arimidex (Anastrozole)
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Arimidex

Arimidex is an aromatase inhibitor approved by the U.S. Food and Drug Administration (FDA) to treat postmenopausal women diagnosed with advanced-stage or metastatic hormone-receptor-positive breast cancer.

Other names for this medication:
Altraz, Altrol, Anabrez, Anastrocare, Anastrozole, Anatero, Anazol, Armilon, Armotraz, Femistra, Femitraz, Qubol, Redest, Rimidex, Stazonex, Xenosoul

Similar Products:
Colcrys, Rogaine, Glucotrol, Seroquel, Arcoxia, Rulide, Xenical, Symmetrel, Trazaril, Recozol, Easworm, Gabaneuron, Corbionax, Labopene,

Also known as: Anastrozole

Description

You should take Arimidex according to your doctor’s or healthcare provider’s instructions.

When to take

You can take your Arimidex dose at any time of the day. But try to stick with the same time each day.

To help make sure that you don’t miss a dose, try setting a reminder on your phone. A medication timer may be useful, too.

Taking Arimidex with food

You can take Arimidex either with or without food.

Can Arimidex be crushed, split, or chewed?

No, you shouldn’t crush, split, or chew Arimidex tablets. Instead, you should swallow them whole. If you have trouble swallowing pills, talk with your doctor or pharmacist.

Dosage

The following information describes Arimidex dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

Drug forms and strengths

Arimidex comes as 1-mg tablets that are taken by mouth.

Dosage for breast cancer

The usual dosage of Arimidex for breast cancer is one tablet taken once a day. It’s best to take your dose at the same time each day.

What if I miss a dose?

If you forget to take a dose of Arimidex, take the missed dose as soon as you remember. However, if it’s almost time for your next dose, just skip the missed dose and take your next dose as usual. Don’t take two doses together to make up for a missed dose.

To help make sure that you don’t miss a dose, try setting a reminder on your phone. A medication timer may be useful, too.

Will I need to use this drug long term?

Arimidex is meant to be used as a long-term treatment for breast cancer. If you and your doctor determine that Arimidex is safe and effective for you, you’ll likely take it long term.

The length of time that you’ll take this drug depends on the type of cancer you’re using it to treat. Below we describe the typical length of time that Arimidex is given. But to know for sure how long you should take Arimidex, talk with your doctor.

For advanced breast cancer

If you’re taking Arimidex to treat advanced breast cancer, you’ll usually take the drug for as long as your doctor feels this treatment is right for you. (With advanced breast cancer, the cancer has either spread to nearby areas or lymph nodes, called locally advanced breast cancer, or spread to other parts of your body, called metastatic breast cancer.)

For early breast cancer

If you’re taking Arimidex as adjuvant treatment of early breast cancer, you’ll usually take the drug for at least 5 years. Adjuvant treatment is used to lower the risk of your breast cancer coming back or spreading after it’s already been treated with surgery. (With early breast cancer, the cancer hasn’t spread out of either your breast or the lymph nodes in your armpit.)

It’s not currently known if Arimidex should be continued after these 5 years. And if so, it’s not known for how long after the first 5 years it should be taken.

Some studies found that breast cancer is less likely to come back if an aromatase inhibitor is taken for an additional 5 years after the first 5 years of adjuvant therapy. (Aromatase inhibitors are a class of medications.) With this approach to treatment, the drug would be taken for a total of 10 years. However, other studies didn’t show a benefit for extending the treatment beyond 5 the usual years.

In addition, one recent study found that taking Arimidex for a total of 10 years didn’t provide any more benefit than taking it for a total of 7 years.

How long you take Arimidex for early breast cancer will depend on how likely your breast cancer is to come back. It will also depend on your risk of side effects from treatment.

Overdose

If you overdose Generic Arimidex and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Arimidex are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

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Adverse side-effects following attempted removal of tattoos using a non-laser method. Tetany due to excessive use of alcohol: a possible magnesium deficiency. Both cereal grains show varying stimuli on the microbiota composition and microbial products of the ileum and faeces. Potentiometric determination of formation constants of copper(II)/bile acid/peptide in aqueous solution. Matrix metalloproteinase-2, tissue inhibitor of matrix metalloproteinase-2, and transforming growth factor beta 1 in the aqueous humor and serum of patients with pseudoexfoliation syndrome. For predicting all-cause and CV mortality, 2hPG is superior to fPG after renal transplantation. The effects of steatosis on the biological behavior of hepatocellular carcinoma cells were investigated using oleic acid-induced lipid accumulation in HepG2, HLE, PLC, and SMMC-7721 cells. Here, a method using modified Kinyoun acid-fast staining was adapted for use with a Petroff-Hausser sperm and bacteria cell-counting chamber by using a liquid suspension staining technique. Melatonin plays an important role in immunity and has been linked to autoimmune diseases.

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Mixed cryoglobulinemia with a monoclonal IgM component, associated with chronic liver disease. Measurement of spatial gain distribution for a neonlike germanium 19.6-nm laser. This paper is a description of the development and processes of the critical incident technique and its applicability to nursing research, using a recently-conducted study of the Australian nursing workforce as an exemplar. Retinal displacement toward optic disc after internal limiting membrane peeling for idiopathic macular hole. In this review, the PUBMED and Google-Scholar databases were searched to analyze articles that have assessed the variations in both acute and chronic pain responses among different ethnic/racial groups. The data did not support the generic concept, or many previously proposed species groupings, based on adult morphology. Further, recent developments in seatbacks have introduced new designs into the field that have not been compared to more traditional designs. Using the accelerated testing paradigm, these results will then be extrapolated to mean time-to-failure in the operating intraocular environment. In this study, we report our experience on immediate reconstruction after resection of primary or metastatic chest wall tumors, to restore protective function and elasticity of chest or sternum.

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Plasma levels of celecoxib were comparable with levels obtainable in humans. From a scaling argument, we also show the power-law decay of the autocorrelation function C(sigma)(t)--t(-alpha), which is the probability to find the Ising spins in the initial state sigma after t time steps, with the state-dependent nonuniversal exponent alpha. Here, we assessed the utility of a newly developed recombinant subunit vaccine based on the HeV attachment (G) glycoprotein in the AGM model. So, in this way, both the EC and the DC are a link between the natural and the acquired immunological mechanisms. Single trial time frequency analysis showed higher GBA when a larger amplitude VEP/P100 occurred. The Effect of Stereotype Threat on Age Differences in Prospective Memory Performance: Differential Effects on Focal Versus Nonfocal Tasks. Besides, MS had no impact on the acquisition of extinction learning. Although the participant reached criterion and maintained performance in each of the conditions, the provision of speech output alone and in combination with orthographic feedback resulted in more efficient spelling than the provision of orthographic feedback alone. Tumor necrosis rate adjusted by tumor volume change is a better predictor of survival of localized osteosarcoma patients.

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Osteoporosis medications are usually safe, especially if used correctly with proper patient education. At the age of 1 year and 3 months, a 3-dimensional computed tomographic scan demonstrated that the vessel on the duodenum was the superior mesenteric vein (SMV), and it formed the portal vein with the splenic vein at the porta hepatis. Russell Silver syndrome (RSS) is a genetic disorder of unknown aetiology. Body height in children with growth hormone deficiency: results following 5-l5 years of treatment. With one boron-containing therapeutic agent on the market and several more in various stages of clinical trials, the occurrence of this class of compound is likely to grow over the next decade and boron could become widely accepted as a useful element in future drug discovery. Hematopoietic lineage cell-specific protein 1 functions in concert with the Wiskott-Aldrich syndrome protein to promote podosome array organization and chemotaxis in dendritic cells. Small bowel bacterial overgrowth is a common complication of short bowel syndrome, and although it is often controlled with antimicrobial therapy, alternative strategies may occasionally be needed.

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Corticotropin-releasing hormone directly and preferentially stimulates dehydroepiandrosterone sulfate secretion by human fetal adrenal cortical cells. To report 3 cases of unilateral neuroretinitis associated with the chikungunya fever (CHIKV). The aim of the study was to evaluate the frequency of occurrence of decreased bone mineralization in the group of university students and qualification of dependence between this abnormality and dietary factors and nutritional status. Impact of growth hormone and dehydroepiandrosterone on protein metabolism in glucocorticoid-treated patients. Krp1, also called sarcosin, is a cardiac and skeletal muscle kelch repeat protein hypothesized to promote the assembly of myofibrils, the contractile organelles of striated muscles, through interaction with N-RAP and actin. General introduction The concept of visceral hypersensitivity is accepted as being germane to several functional gastrointestinal disorders (FGIDs). The most important characteristics were whether framing is manipulated by changing reference points or by manipulating outcome salience, and response mode (choice vs.

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Expression of ectonucleotide pyrophosphate phosphodiesterase and peroxisome proliferator activated receptor gamma in morbidly obese patients. Addicted patients may present for anesthetic care in a variety of circumstances in everyday elective surgeries or in acute or life-saving situations, such as emergency Cesarean delivery or trauma surgery. The purpose of this article is to characterize changes in the corneal aberration structure after PRK and to demonstrate the effect of pupil dilation on these changes. At the time of admission, the patient was at high risk of radiation injury to the fetus, so a coronary angiogram was postponed until the second trimester. Interactions of alfalfa hay and sodium propionate on dairy calf performance and rumen development. Cutaneous electroreceptors in the platypus: a new mammalian receptor. The results of these reconstructions were evaluated for complications and functional outcome. We report a case of echinococcosis of the rib with epidural extension in a young adult who presented with paraparesis and back pain.

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Additionally, endogenous opioid peptides released during ischemia also enhance ischemic tolerance. An important goal for future research is to identify which individual difference and which contextual factors are most important in determining who will, and who will not, behave in an aggressive manner when intoxicated. We identified a total of 47,219 patients (age 18 years or older) who were admitted to the hospital for complicated skin and skin-structure infections from April 1, 2003, through March 31, 2004, and who received intravenous antibiotics during the first 2 hospital-days (ie, initial antibiotic therapy). The work cannot be changed in any way or used commercially without permission from the journal. This finding reveals not only one of the major mechanisms underlying GDA(BMP)-dependent recovery from SCI, but also the potential of POSTN as a therapeutic agent for traumatic injury of the CNS. Early diagnosis of diffuse brain damage resulting from a blunt head injury. A nationwide survey was conducted in 2016 as a part of the mandatory quality-control program by the Korean Society for Cytopathology. PCR fingerprints of 89 Salmonella isolates belonging to 22 serotypes were obtained using ERIC PCR (enterobacterial repetitive intergenic consensus PCR) and AP PCR (arbitrarily primed PCR) to evaluate the ability of different fingerprinting methods to differentiate or identify serotypes and subtypes.

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An outcomes guarantee is a type of performance-based risk-sharing arrangement that adjusts payments according to prospectively tracked outcomes. Vgamma2Vdelta2 T cells can also recognize high levels of IPP in certain tumors and in cells treated with pharmacological agents, such as bisphosphonates and alkylamines, that block farnesyl pyrophosphate synthase. We have also shown that TULA-2 exhibits a certain degree of substrate specificity. An evaluation of the hemizygous transgenic Tg.AC mouse for carcinogenicity testing of pharmaceuticals. Right nonrecurrent inferior laryngeal nerve and arteria lusoria: the diagnostic and therapeutic implications of an anatomic anomaly.

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Evolutionary insights about bacterial GlxRS from whole genome analyses: is GluRS2 a chimera?. In human cells, ribonucleoproteins derived from A/Mallard/Marquenterre/MZ237/83 showed reduced transcription/replication activity and reduced NP binding to the PB1-PB2-PA complex (P) or to the isolated PB2 subunit, as compared to the ribonucleoproteins derived from A/Paris/908/97. Selectable markers enable transgenic plants or cells to be identified after transformation. Therefore, our objective was to examine the genetic regulation of ASP and associated pleiotropic effects. Knee Alignment is Quantitatively Related to Periarticular Bone Morphometry and Density, Especially in those with Osteoarthritis.

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Changes in climate can proceed rapidly, on time scales as short as centuries or even decades, as indicated by data for the Younger Dryas (a period of globally cold conditions interrupting recovery of the Earth from the last ice age) and the Little Ice Age (a cold snap extending from about 1250 to about 1850 ad). Mandibular pain and movement disorders, focusing on the temporomandibular joint. This observation is particularly intriguing in the context of cardiac hypertrophy, where serum response factor transactivation is a key event necessary for the induction of cardiac hypertrophy in response to increased afterload. A new sesquiterpene ether, nardonoxide ( 1), with the nardosinane skeleton, was isolated from the underground parts of NARDOSTACHYS CHINENSIS Batalin (Valerianaceae), growing in the province Sichuan (China). On the other hand, uncomplexed ligand N-(2-hydroxyacetophenone) glycinate (NG) fails to generate a significant amount of ROS and concomitant induction of apoptosis in CEM/ADR5000 cells. Paediatric injuries at Bugando Medical Centre in Northwestern Tanzania: a prospective review of 150 cases. The collecting duct (Bellini) carcinoma is an infrequent malignant renal tumor.

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quadriceps venom gland with Sanger sequencing in combination with whole-transcriptome shotgun deep sequencing. Efficacy of only left side approach in a case of unsuccessful reconstruction of the right hepatic artery after left hepatic lobectomy with caudal lobectomy. sparsa DNA and flavonol glycosides and some ellagitannins in the leaves 8 days after inoculation, suggesting a possible role for these phenolics in the defense. Little is known about the prevalence of IBS symptoms among students. Sleeve technique is a feasible and efficient approach in stenting of coronary bifurcation stenoses. The frequency of reported occurrence of bronchitis, upper respiratory infection, and giardiasis were also statistically significantly elevated. The experience of two specialist nurses providing critical care on board RFA CARDIGAN BAY during a recent Role 2 Afloat exercise is described. These molecules have a crucial role in the homeostasis of haematopoietic cell populations in the adult and also contribute to graft-versus-host disease.

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Role of heredity and upbringing in the development of schizophrenia. In vivo Biodistribution of Radiolabeled Acoustic Protein Nanostructures. melanogaster because a specific group of genes, which encode specific proteins, are can you take claritin allergy medication probably activated in order to withstand the onslaught of stressful conditions. Doppel expression is regulated by the Brn-3a and Brn-3b transcription factors. To address this question, we measure functional activity of known OCS-blocking mutants with H-to-Q replacements of C-terminal histidines of the T-domain. The objective of this preliminary study was to evaluate the applicability of the Dimodent predictive equation in sex determination in a sample of Lebanese young individuals. Preventing iatrogenic injury from inadvertent intracranial migration of a urinary foley catheter while controlling profuse epistaxis after severe craniofacial trauma. The authors describe a patient with previously diagnosed hemihypertrophy of the trunk who had a history of large thoracic lipomas resected during infancy, a thoracic hump due to adipose proliferation within the thoracic paraspinal musculature, and scoliotic deformity. Scaling was induced on mice after topical application of chymostatin and leupeptin. Timely treatment with topical steroids led to resolution of the disease with full visual recovery without any residual symptoms or signs.

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For the first time we show that acute sleep restriction therapy is associated with reduced objective total sleep time, increased daytime sleepiness, and objective performance impairment. Transthoracic Coronary Flow Data at Rest Predict High-Risk Stress Tests. Serum levels of interleukin 1 and tumor necrosis factor alpha correlate with peritoneal adhesion grades in humans after major abdominal surgery. Polyandrous females produce sons that are successful at post-copulatory competition. Aleutian Disease is a significant biological factor causing substantial losses in mink farming. To study the clinical features of the sudden sensorineural hearing loss (SSHL) in children. Toward this end, we focused on diffuse large B-cell lymphoma (DLBCL) as a model because there is differential cholesterol biosynthesis driven by B-cell receptor (BCR) signaling in germinal center (GC) versus activated B-cell (ABC) DLBCL. Cloning and characterization of the BLR2, the homologue of the blue-light regulator of Neurospora crassa WC-2, in the phytopathogenic fungus Bipolaris oryzae.

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The coded paper-pencil questionnaire was disseminated among both partners of 201 heterosexual infertile couples after their first consultation at one of two Belgian fertility clinics between October 2015 and May 2016. Plastic reconstruction of chest wall defects and residual pleural cavities. Subjective and objective clinical improvement was found in 64 per cent, unchanged condition in 23, per cent and new symptoms occurred in 13 per cent. After-school programs (ASPs) across the nation have been asked to increase the amount of activity children accumulate during such programs. None of the 9 left diaphragmatic hernias with intraabdominal stomach died. The synthesis of oxazolines and imidazolines was achieved by activation of isocyanides with water. Uncertainty in decision-making: value of additional information in the cost-effectiveness of lifestyle intervention in overweight and obese people. We determined the complete nucleotide sequence of the chloroplast genome of Selaginella uncinata, a lycophyte belonging to the is biaxin a penicillin drug basal lineage of the vascular plants. Treatment with an mTORC1 inhibitor normalized these parameters and reduced the number of tumour cells. Only women showed a significant correlation between absolute values of S-IgA and the weekly amount of time spent on sports activity measured by a standardized interview expressed in minutes per week.

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We investigated the dependence of the diffusion coefficient on the absorption coefficient by studying the propagation of light emitted by an isotropic source in an infinitely extended medium. Plasma vitamin E and beta-carotene levels of the JRA children were lower in the three forms compared with healthy children. Although viscosupplementation is effective in the short-term, no long-term benefits have been observed. Expression of Cre recombinase in early diploid trophoblast cells of the mouse placenta. In accordance, CXCR4, which is known to attract progenitor cells during tissue regeneration, is up-regulated in lesions of the KO mice. In this overview of recent work with each of these stressors, we assess their plausibility as contributors to the malformations observed in field-collected amphibians. The limit of quantification and the limit of detection were 3.5 and 1.2 ng/ml, respectively. However, acrocentric alpha-satellite, classical satellite, whole-chromosome-painting or all-telomeres sequence probes did not hybridize to the insertion. BPH was induced by daily injections of testosterone propionate (TP) (3mg/kg) for 28 days. Sustainable Developmental Goal (SDG) 3 has already been set for a new target to reduce maternal and neonatal deaths by 2030.

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Knowledge of potential exposure, the natural history of the infection, and incubation periods of each rickettsiosis assist in considering particular rickettsioses. A 21-year-old man presented for evaluation of maximum dose of thorazine erythematous papules and plaques on both legs that had had a peripheral growth over the past year. In healthy adults, the hemodynamic response from posterior cingulate, orbital frontal cortex, and the parietal lobe strongly differentiated emotional from neutral distractors. We report that Pt nanostars grown from the reduction of H2PtCl6 salt in pure oleylamine present a remarkable crystalline structure and deeply metallic character despite being grown under mild conditions. This potentially curable condition should be considered in a CB allograft recipient with alveolointerstial lung disorder. The purpose of this study was to determine the initial results obtained with a unique reconstructive implant, the porous tantalum metaphyseal cone, designed as an alternative treatment for severe tibial bone loss following total knee arthroplasty. Hospital admissions for non-purulent lower extremity cellulitis (NLEC) are common and can be prolonged and costly.

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The worldwide introduction of total mesorectal excision in combination with the increasing use of radio(chemo)-therapy has led to an improved prognosis. The mechanism of synthesis of Chl b and localization of this reaction in the chloroplast are essential steps toward understanding LHC assembly. gigas), the estimates are based on counts of positively identified RGCs retrogradely labelled with the enzyme horseradish peroxidase injected into the retinorecipient nuclei. Although choristomas have been seen occasionally occurring with nevus sebaceus, an associated ipsilateral, regional, congenital giant hairy nevus is rare. Three days later, she presented with pain, hand motions vision, and severe anterior uveitis and vitritis.

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Previous work from our lab has shown that the flat interface nerve electrode (FINE) can be used to selectively stimulate fiber populations within a nerve trunk. In the three trials that researched the influence of DHA-rich preparations, no significant effects were reported. We show that mice deficient for both bmi1 and M33 present stronger homeotic transformations of the axial skeleton as compared to each single Polycomb group mutant, indicating strong dosage interactions between klonopin and alcohol bluelight those two genes. Of the 3 Cu-Ni-Ti products, the least differences were found between Cu-Ni-Ti 27 and Cu-Ni-Ti 35, thereby questioning the justification for 3 similar products. This study aimed to explore the dynamic changes of lesion patterns and hemodynamic characteristics in patients with internal carotid artery stenosis (ICAS). The compound (2E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one, cardamonin) was isolated from ethanol extracts of C. Detection of 12 respiratory viruses with two-set multiplex reverse transcriptase-PCR assay using a dual priming oligonucleotide system.

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However, the force of the lateral rectus muscle was significantly greater in those with constant exotropia than in the normal controls. The data for open sea sediments enabled the establishment of background levels of contamination for the region. Removal of S6K1 and S6K2 leads to divergent alterations in learning, memory, and synaptic plasticity. One TF is encoded by a single gene but regulates the expression of several other genes leading to the activation of complex adaptive mechanisms and hence represents major molecular targets to genetically improve the tolerance of crop plants against different stresses. The first step in identifying risk factors for injuries is to characterize the myoelectric activity of different muscles after ground contact, especially when fatigue is a limiting factor. Mutations in PEX10 is the cause of Zellweger peroxisome deficiency syndrome of complementation group B. Patients were treated twice a week for 3 weeks for a total of 6 treatments and were evaluated at baseline, 2 weeks post procedure, and 6 and 12 months post procedure. The SLI and control groups showed similar SDE and a similar pattern of response across materials.

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While expression of genes fused to the taclac promoter is constitutive in one vector, the lacIq gene carried by the other vector allows a controlled, IPTG-inducible gene expression. The enhanced skin permeation of archaeosomes may be attributed to their chemical structure and physicochemical properties such as particle size, surface charge, stability, and fluidity of their lipid bilayer. Using molecular investigations and heterologous expression of human MTMs in yeast cells and in Mtm1 knockout mice, we characterized several naturally occurring MTMR2 isoforms with prilosec cost comparison different activities. Fucoxanthin has been reported to accelerate the bioconversion of omega-3 PUFA and omega-6 PUFA to DHA and AA, respectively. An unusual case of temporal bone encephalomeningocele occurring together with normal pressure hydrocephalus. The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of the key properties of over 2000 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties.

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