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Aratan (Losartan)
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Aratan

Aratan belongs to a group of medicines known as angiotensin-II receptor antagonists. Angiotensin-II is a substance produced in the body which binds to receptors in blood vessels, causing them to tighten. This results in an increase in blood pressure. Aratan prevents the binding of angiotensin-II to these receptors, causing the blood vessels to relax which in turn lowers the blood pressure. Aratan slows the decrease of kidney function in patients with high blood pressure and type 2 diabetes.

Other names for this medication:
Angioten, Anreb, Aratan, Cardon, Cormac, Cozzar, Fensartan, Fortzaar, Giovax, Insaar, Losacar, Losacor, Losamet, Losaprex, Losar, Losargamma, Losartan, Losartanum, Losartic, Losium, Lostan, Lozatan, Maxartan, Prelow, Psycholanz, Resilo, Sarilen, Sarlo, Sartaxal, Tensiohess, Xartan

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Also known as: Losartan

Description

Aratan (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Aratan is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Aratan is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Aratan 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Aratan 25 mg, Aratan 50 mg, and Aratan 100 mg may also contain carnauba wax.

Dosage

Take Aratan tablets orally with or without food. Do not crush or chew it. Take Aratan once or twice a day at the same time. If you want to achieve most effective results do not stop taking Aratan suddenly.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Aratan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Aratan as soon as possible.

In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with Aratan. Correct volume or salt depletion prior to administration of Aratan.

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Similar effect of the red light was also observed when SOD was inactivated with hydrogen peroxide: laser irradiation brought about the reduction of initial absorption spectrum of the enzyme. Evolution and sequelae of acquired lobar emphysema in a premature infant with chronic lung disease. The association of eNOS gene polymorphism with avascular necrosis of femoral head. Treatment should depend on factors such as patient suitability and preference, and patients and clinicians must work together to determine the optimal course of treatment. Enterococcus faecalis tolerates highly alkaline environments, yet the exact pH required for killing E. For 7 patients the ST was obtained and for 6 the complete sequence analysis of the AMR target genes was also defined. In the past, each nucleotide change causing amino acid substitution in a gene in which other mutations responsible for a neurodegenerative disorder had been found was considered as a causative mutation. The detection system developed was both rapid and reproducible and could be used on sub-milligram quantities of cells. Cephalometric airway analysis in obstructive sleep apnea syndrome. The psychological and physiological effects of light and colour on space users.

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The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils. The time of primary surgical repair was noted and analyzed, whenever necessary. However, the commonly used transnasal route is not always available in children with a cleft lip and deviated nasal septum. The Institute of Medicine recognizes that the workplace environment is a crucial factor in the ability of nurses to provide safe and effective care, and thus interactions that affect the quality and safety of the work environment require exploration. The quality of the models, through state-of-the-art external validation procedures employing an external prediction set, is compared to the best models known in the literature for mutagenicity. Instrumentation for quantitative assessment of intestinal viability. Genome rearrangement of a mycovirus Rosellinia necatrix megabirnavirus 1 affecting its ability to attenuate virulence of the host fungus. All decrees and resolutions as to post-acute stroke rehabilitation were collected from each Italian region. Differently from previous evaluations, special emphasis was given to effectiveness in real world applications such as image mosaicing and stitching, where robustness with respect to strong image misalignments and light scattering effects is required. Herein, we demonstrate that GC conditioning during the differentiation of myeloid progenitors into macrophages (Mphis) results in their enhanced LPS responsiveness, demonstrated by an overexpression of the inflammatory cytokines TNF-alpha, IL-6, and IL-12.

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Real-time PCR detection and quantitation of Chlamydophila psittaci in human and avian specimens from a veterinary clinic cluster. These results suggest a way in which alloying provides a means of designing this class of exotic phases to be more robust. Within these regions, PIN1a forms narrow canals that likely pattern future veins. Human NB cell lines (Kelly and SH-SY-5Y) and NB1691-luc mouse xenografts were employed. Passive antibody delays development of cell-mediated immunity in rats receiving renal allografts. In this pilot study, topical application of ISDN seems to be beneficial to improve symptoms for patients with cold type CRPS1, but further study is needed. Impact of nonresponse on Medicare Current Beneficiary Survey estimates. Protracted fluoxetine treatment reduced the time on the anxiogenic open arms and increased the entries into the safe closed arms in sham-operated C3H mice.

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5) About 10 times higher concentrations of As2O5 were necessary to induce a similar extent of inhibition of gluconeogenesis, decrease in O2 consumption, and in ATP content as compared with As2O3. Although such a population framework usually fits best to cancer epidemiology, most other diseases could benefit from such an approach. Pornography Use and Marital Separation: Evidence from Two-Wave Panel Data. Improving veterinary care of cattle belonging to private citizens. Patients undergoing pediatric cardiac surgery received aprotinin from 2005 to 2007 and EACA from 2008 to 2009. By flow cytometry and confocal fluorescence microscopy, we demonstrate that 3-17I specifically targets EpCAM-positive cell lines. We therefore used Bayesian approaches with microsatellite data to try and define British natterjack population structure, and thus inform conservation management.

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The meta-analysis revealed consistent clusters within bilateral amygdala, anterior hippocampus, anterior and posterior parahippocampal gyrus, the ventral visual stream, left lateral prefrontal cortex and right ventral parietal cortex. The effect of inserting genes involved in the reductive branch of the tricarboxylic acid (TCA) cycle on citrate production by Aspergillus niger was evaluated. Sorafenib and lithium chloride combination treatment shows promising synergistic effects in human glioblastoma multiforme cells in vitro but midkine is not implicated. SVC obstruction can be caused either by invasion or external compression of the SVC by contagious pathologic processes involving the right lung, lymph nodes, and other mediastinal structures, or by thrombosis of blood within the SVC. Factors determining completeness of inclusion are discussed, and it is concluded that, in an unselected series of patients with ulcerative colitis, close cancer surveillance is indicated, although prophylactic surgery does not seem to be generally warranted. The CCAS measures level of involvement of each parent in 21 child care activities. Common adverse events were neutropenia, diarrhea, nausea, anemia, upper respiratory tract infection, thrombocytopenia, and fatigue. Most constructs from the TTM were useful in explaining exercise adoption in older sedentary women. According to the characteristics of medical image and wavelet transform, a scalable coding algorithm is presented, which can be used in image transmission by network. population, we analyzed data from the National Health and Nutrition Examination Survey II for persons 12 to 74 years of age.

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Hyperleukocytosis in acute leukemia is associated with higher early mortality due to the major complications of leukostasis, tumor lysis syndrome (TLS), and disseminated intravascular coagulopathy (DIC). Mechanisms of regulation of RNA synthesis in lower and higher organisms. Anemia coincident with hyporesponsiveness to erythropoiesis-stimulating agents is an ongoing and prevalent problem in children with chronic kidney disease (CKD). The T-pilus component VirB2 cofractionated with high-molecular-mass core protein complexes extracted from the membranes, and the presence of VirB8 as well as its dimer interface were important for this association. stems reacted either concentrically or patchily to environment triggers, and it was fresh water availability and not tidal inundation that affected radial increment. The wet zone is located near the surface of the soil and the depth of it is determined by a balance between rainfall and the rate of water uptake. Studies examining safety and BP-lowering efficacy have shown that a renin-angiotensin-aldosterone system blocker plus a calcium channel blocker as well as a combination of diuretics and beta-blockers or diuretics plus an angiotensin-converting enzyme inhibitor or angiotensin II type 1 receptor blocker achieves greater BP reductions than monotherapy. Clinical practice of a child and adolescent psychiatric service as evaluated by parents. Pediatric calcaneal nonunion due to cartilaginous interposition: a case report. In addition, biliary metabolites were measured in order to verify that B(a)P was absorbed and metabolised.

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Potential of CLSM in studying some modern and fossil palynological objects. This increase was related to the length and material of distribution pipes. Gluten and wheat intolerance today: are modern wheat strains involved?. However, LOOHs can also participate in redox reactions, the nature and magnitude of which often determines whether peroxidative injury is exacerbated or prevented. These normative data will aid in estimating the magnitude of change during clinical trials of cognition-enhancing agents and make it possible to derive more directly interpretable composite scores. Moreover, it involves contributing to a culture of safety by improving work conditions in the OT. However, relative matrix effects are negligible--unless extremely divergent matrixes are compared--and do not compromise the relative quantification that is aimed for in nontargeted metabolomics studies. As a class of noncoding RNA, microRNA (miRNA) plays important roles in plant growth, development, and stress response.

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The renin angiotensin system (RAS) is a central player in blood pressure control. Chemokines bind to G protein-coupled receptors and cause conformational changes that trigger intracellular signaling pathways involved in cell movement and activation. Effects of vitamin E on reproductive protection in pregnant mice infected with pseudorabies virus (PRV) via regulating expression of Toll-like receptors (TLRs) and cytokine balance. Restoration of the labral buttress and capsular tension by arthroscopic capsulolabroplasty successfully stabilized shoulders with posteroinferior multidirectional instability. The delivery of one twin most often results in expulsion of the second twin. The objective of this study was to review all articles related to spinal instability to determine a consensus statement for a contemporary, practical definition applicable to thoracolumbar injuries. A yoaW mutant exhibited a biofilm structure with reduced depth, and a sipW mutant exhibited only surface-attached cells and did not form a mature biofilm. Promyelocytic leukaemia nuclear bodies (PML NBs) are structured protein complexes associated with the nuclear matrix. Applications of these approaches to hydride transfer in dihydrofolate reductase are consistent with experimental measurements and provide significant insight into the protein conformational changes that facilitate the hydride transfer reaction.

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These findings reinforce the importance of addressing limited functional health literacy in clinical practice. This study demonstrates that opioids are very common exposures during pregnancy. A thematic analysis of clinician, technical, patient, and organizational factors associated with technology acceptance is also presented. Despite more advanced patient age, stages of aortic valve disease, complexity of operations including more demanding stentless bioprosthesis implantation techniques, early and late postoperative results are in favor of stentless bioprosthesis. Incorporating spatial variation could potentially enhance information coming from survival data.

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Nervous signs included depression, absence of menace response, vertical nystagmus, and terminal convulsions. Human T lymphocyte proliferative response to resting porcine endothelial cells results from an HLA-restricted, IL-10-sensitive, indirect presentation pathway but also depends on endothelial-specific costimulatory factors. Eosinophils appear to harbour the highest concentration of preformed TF among all blood components under resting conditions. The quantification of salivary oxytocin (OXT) concentrations emerges as a helpful tool to assess peripheral OXT secretion at baseline and after various challenges in healthy and clinical populations. Two different techniques to overcome the high phytotoxicity of the soil were first evaluated on a laboratory scale: reduction of soil phytotoxicity by the addition of a powerful metal immobilizing substance and use of metal-tolerant plants. Genomewide analysis of epistatic effects for quantitative traits in barley.

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Commercial naphthenic acids and the organic fraction of oil sands process water downregulate pro-inflammatory gene expression and macrophage antimicrobial responses. The influence of higher-order phase dispersion on the pulse generation in femtosecond Kerr-lens mode-locked lasers for small net group-velocity dispersion is numerically analyzed. The preparation of rat liver high molecular weight mitochondrial RNA free of cytoplasmic ribosomal RNA. Finally, the interface thickness is governed by the coefficients of the gradient of order parameters in the non-local interface energy. Possible mechanisms of action of vitamin D include stimulation of insulin secretion and effects on insulin sensitivity. SLE Responder Index-4 (SRI-4) was calculated at 12 and 24 months. This systematic review asks what employment impact have these interventions had and how might they work better?. Obstetric and gynecologic challenges in women with Ehlers-Danlos syndrome. In vitro, the effect of chitooligosaccharides on proliferation of pancreatic islet cells and release of insulin was detected with optical microscopy, colorimetric assay, and radioimmunoassay respectively.

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The anti-inflammatory effect of low-dose radiation therapy involves a diminished CCL20 chemokine expression and granulocyte/endothelial cell adhesion. It is extremely rare in children and has not been reported previously before the age of 22 Years. Here, we present structures of DNA complexed with the response regulator KdpE, a member of the OmpR/PhoB family. Neurotonic discharges are detected when the recurrent laryngeal nerves are manipulated during surgical dissection. Compared with control patients, cancer patients had a higher excretion of cortisol, adrenaline, and noradrenaline, although noradrenaline excretion reached statistical significance only when normalized to creatinine excretion. The E3/19K protein interferes with antigen presentation and T cell recognition, whereas the E3/10.4K, 14.5K, and 14.7K proteins can protect cells from tumor necrosis factor alpha-mediated lysis.

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Another important aspect in receptor research is that mutation of a single receptor gene sometimes result in different phenotypes and even different modes of inheritance. Nucleus reuniens of the midline thalamus: link between the medial prefrontal cortex and the hippocampus. Self- enucleation of eyes in schizophrenia- an unusual mode of deliberate self how much is one dose of tramadol harm. Granulosa-lutein cells were obtained from women undergoing in vitro fertilization. The authors analyse 22 cases of suprasellar meningiomas, drawing attention to factors influencing on the surgical outcome.

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To address this problem, we analyze the viral metagenome of a northeast Pacific hydrothermal vent with a comprehensive database of spacers derived from the clustered regularly interspaced short palindromic repeat (CRISPR) putative immune system. Mycophenolate mofetil (MMF), a new immunosuppressive agent, has been used successfully in patients with solid organ transplants and rheumatoid arthritis. Trilostane treatment in dogs with pituitary-dependent hyperadrenocorticism. To date there has been little literature to identify what constitutes the important features in these systems, nor research into whether these systems actually improve the quality of care or the outcome of pregnancies. The impact of such a policy would not be trivial, especially in areas with older, foreign-born, Asian, or Hispanic donors. There was no statistically significant different between the groups in the duration of surgery, estimated blood loss, or infectious morbidity. PlexinA1 may play an important role in the occurrence and development of gastric carcinoma, and be related to tumor angiogenesis and proliferation. Diabetic modifier QTLs in F(2) intercrosses carrying homozygous transgene of TGF-beta.

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Transforming growth factor beta (TGF-beta), an inducer of matrix synthesis, potently enhances mRNA and protein of a recently characterized MMP inhibitor, TIMP-3, in bovine articular chondrocytes. Distinct functional programming of human fetal and adult monocytes. Variables related with BCVA, foveal thickness and mean retinal sensitivities were analyzed in different types of DME patients using one-way ANOVA or Kruskal-Wallis test. Indications, techniques, functional results of the ileal ureter, and prognosis of these patients are discussed. This review summarizes the recent studies on CD9 and concludes that it does not always act as a progression and metastasis suppressor. The spectrophotometric analysis of the interaction of these diamidines to test their effects on the melting temperature of leishmanial DNA suggests non-intercalating binding. Although not statistically significant, we did note a trend toward a lower long-term rate of disease-free survival in patients with IDC.

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We hypothesized that left atrial stiffness (LASt) and atrial dyssynchrony may increase the risk of CS in patients with PFO. Effects of Whole Body Vibration on Glycemic Indices and Peripheral Blood Flow in Type II Diabetic Patients. When comparing 4 and 12 weeks, there was a significant increase in new bone formation within groups BG and BG/CS, but not C. Adenosine, through the A1 receptor, inhibits vesicular MHC class I cross-presentation by resting DC. Due to the limited quality of the evidence currently available, more high-quality RCTs are required. The chemical composition of the extracts and fractions were analyzed by chromatographic (GC, HPLC) and spectroscopic (UV, UV-VIS) techniques. Adenovirus tunes the function of antiviral autophagy, and counters innate defense by virtue of its early proteins E1A, E1B, E3, and E4 and two virus-associated noncoding RNAs VA-I and VA-II. The exoB mutation could be corrected not only for EPS production but also for the ability to form nitrogen-fixing nodules on alfalfa by one particular cosmid clone of A. Patients with a partial dihydropyrimidine dehydrogenase (DPD) deficiency have an increased risk of developing severe 5-fluorouracil-associated toxicity.

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Dye concentration encapsulated by the niosomes in the samples decreased while the population and size distribution of the niosome remained largely unchanged. This applicator combines the uniform heating capabilities of large area conformal microwave array (CMA) flexible printed circuit board applicators with a patient interface (coupling bolus) that facilitates positioning of brachytherapy sources at a fixed distance (e.g. It is found that ICA can successfully detect and separate different brain activities into separate components during motor imagery. The use losartan cozaar 100 mg tablet of rating scales for computer analysis of the affective symptoms in old age. Immigrant adolescents showed a greater likelihood of not fulfilling recommendations for the consumption of meat, fish, eggs, legumes, bread/cereals, and milk/dairy products. PEA performed as a single-shot therapy can be used as a minimally invasive and safe supplement to medical therapy in the treatment of secondary or tertiary hyperparathyroidism in selected patients. A total of 38 consecutive patients with primary breast cancer received mastectomy in Cancer Center of Sun Yat-sen University from Dec.

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