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Apsolam (Alprazolam)

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Apsolam is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder. It's also used in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Apsolam, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Apsolam is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Acalm, Alcalm, Alflux, Alpanol, Alparazole, Alpaz, Alpraday, Alpramax, Alprastan, Altrex, Alwe, Alzin, Alzoax, Alzopam, Anxico, Anzilum, Axizox, Benzax, Calmef, Cooltime, Depoxit, Depser, Dizeral, Eurolam, Exiten, Fultop, Hipose, Kurelam, Mediprex, Mentolift, Nucalm, Pifzot, Pronext, Resta, Romipraz, Samrox, Serex, Silam, Tagat, Tenfree, Trazopin, Unixl, Viprax, Zenax, Zoltweet

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Also known as: Alprazolam


Apsolam (alprazolam) is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). It is thought that alprazolam works by enhancing the activity of certain neurotransmitters in the brain.

Apsolam is used to treat anxiety disorders and anxiety caused by depression.

Apsolam is also used to treat panic disorders with or without a fear of places and situations that might cause panic, helplessness, or embarrassment (agoraphobia).

It is dangerous to purchase Apsolam on the Internet or outside the United States. The sale and distribution of medicines outside the U.S. does not comply with safe-use regulations of the Food and Drug Administration (FDA). These medications may contain dangerous ingredients, or may not be distributed by a licensed pharmacy.


This section provides information on the proper use of a number of products that contain alprazolam. It may not be specific to Apsolam. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is used for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the extended-release tablet or tablet whole with a full glass of water. Do not break, crush, or chew it.

If you are using the orally disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not remove the tablets from the bottle until you are ready to take it. Place the tablet immediately on the top of your tongue. It should melt quickly and be swallowed with saliva.

If you are using the oral liquid, measure the dose with a marked measuring spoon, oral syringe, or medicine cup.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For anxiety: For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.25 to 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 4 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For panic disorder: For oral dosage form (extended-release tablets): Adults—At first, 0.5 to 1 milligram (mg) taken in the morning once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.5 mg taken in the morning once a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of alprazolam can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, and fainting.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details.

Side effects

The most common side effects associated with Apsolam are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of alprazolam in the elderly. However, elderly patients are more likely to have unwanted effects (eg, severe drowsiness, dizziness, confusion, clumsiness, or unsteadiness) and kidney, liver, or lung problems, which may require caution and an adjustment in the dose for patients receiving this medicine.

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The C-terminal tail of Tom1L1 contains a novel clathrin-interacting motif responsible for interaction with the C-terminal region of clathrin heavy chain, which is important for exogenous Tom1L1 to rescue endocytosis of EGFR in Tom1L1 knocked-down cells. Furthermore, a discrepancy was demonstrated between the plasma concentrations of DHE which rapidly reach peak levels and quickly decline, and its long lasting vasoconstrictor activity. The aim of this study was to compare the effects of the alpha(2)-adrenergic-receptor antagonist yohimbine, the 5-HT(lA)-receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and the opioid-receptor antagonist naloxone (all of which have been shown to stimulate male sexual arousal/motivation in rats) on sexual responses in male dogs. Phenotypic comparison of the three populations of human lymphocytes defined by CD45RO and CD45RA expression. In their totality, 5-LO products of arachidonic acid contribute to the impairment of the normal glomerular filtration and sieving functions that attend acute inflammatory injury in the renal glomerulus and to the subsequent progression of glomerular destruction. In Pitressin-treated animals (3 days, 200mU/day), an increase in number of the neurosecretory granules and an appearance of the disposal process of the excess neurosecretory granules are characteristic in the nerve terminal. Conventional MRI was used to evaluate for brain infarcts and white matter hyperintensity volume. Emotional syndrome and right temporal behavior of Guillaume Apollinaire. New frontiers for health information systems using Epi Info in developing countries: structured application framework for Epi Info (SAFE).

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Multiple courses of antenatal corticosteroid therapy in patients with preterm premature rupture of membranes. Among the less common alpha-Proteobacteria the genus Sphingomonas and the genera Afipia, Bosea or Bradyrhizobium of the Bradyrhizobiaceae family were detected. Therefore, in this study features were examined thoroughly and arranged by maximizing the Mahalanobis distances between normal and dysphagic classes. SmI2 reduced thioesters as synthons of unstable acyl radicals: direct synthesis of potential protease inhibitors via intermolecular radical addition. This hypothesis proposes a physiological role for uncoupling protein-3 (UCP3) in the export of fatty acid anions from muscle and brown adipose tissue (BAT) mitochondria when fatty acids are the predominant substrate being used. These results suggest a fast inhibition mechanism realized in the contrast-specific center-surround antagonism of classical receptive fields for brief inhibition and a slower, higher level cortical processing that is indifferent to contrast polarity for prolonged inhibition. Molecular evolution of the homeodomain family of transcription factors. It also discusses how some of the key features of CE-MS were exploited in selected metabolomic applications. Drinking elicited a return to volumes similar to those of control rats, 3-4 h after lidocaine administration. Mutational analysis shows that the proposed S1 helix, despite having several highly conserved residues, can be heavily mutated without significantly altering channel function.

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About one of the five ethoxide ligands of Nb(OEt)(5) was released during the Nb(OEt)(5) pulse and the rest during the D(2)O pulse. Immunophenotypic analyses of isolated cellular fractions using polyclonal and monoclonal antibodies against ovarian carcinoma-associated antigens showed significant immunologic intratumoral heterogeneity. Quantitative changes of signs and symptoms associated with acute alcohol withdrawal: incidence, severity and circadian effects in experimental studies of alcoholics. Sixty-seven patients were identified, of whom 27 were treated medically only and not considered here. Direct contact of circulating blood with the synthetic surfaces of the CPB system may be the main cause of the systemic inflammation. The relationship between five CT findings and five pulmonary function parameters was evaluated before and 3 months after low-dose erythromycin therapy in 24 patients with DPB retrospectively.

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These data show that the ricin gene family contains at least seven members that have the ability to inhibit translation and that may contribute to the toxicity of R. In order to identify the degree of salinity tolerance of the indica and japonica rice groups, 10 varieties were tested under saline and non-saline conditions. Because of their non-overlapping toxicity, we evaluated their combination as salvage therapy in a phase II study. As for the four other nitrofurans, nifursol disappears from tissues within a few days after treatment of food-producing animals. Progestin reversed estrogen-induced MOR internalization, suggesting that progesterone blocked estrogen-induced endogenous opioid release, relieving estrogen inhibition and facilitating lordosis. parahaemolyticus by bacteriological methods and confirmed by tl gene-based conventional PCR. Antifungal amides from Piper scutifolium and Piper hoffmanseggianum. This is one reason why the commonly used set of EPA-PAHs, which includes naphthalene and 3-ring PAHs, is considered inappropriate for the assessment of the health hazard in the case of tar-containing materials in hot recycling.

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Intensity modulated arc therapy (IMAT) is an intensity modulated radiation therapy delivery technique originally proposed as an alternative to tomotherapy. Cancer is the second leading cause of death in industrialised countries like the United States, where a significant proportion of workers engage in shift work, making a hypothesised relation between light exposure at night and cancer risk relevant. Loss of CHFR expression correlated significantly with the diffuse phenotype. The simple columnar epithelium investing the villus is surmounted by a striated border consisting of slender projections of the cell surface. The computed tomographic (CT) findings of ruptured abdominal aortic aneurysms are often straightforward. The omnific mediator system composed of sphingosine 1-phosphate (S1P) and its five G-protein-coupled receptors, designated S1P(1)-S1P(5), affects diverse cellular functions in the nervous, endocrine, cardiovascular and immune systems.

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When combined with inhibition of caspase 3 activity (by Bcl-X(L) overexpression), inhibition of TRAIL-induced autophagy results in luminal filling. 10 palatalized misarticulation patients (6 male, 4 female) with the age of 4-14 years were included in the study. A Medline search to determine the examination of a patient with suspected BIH or DST yielded several articles on this topic but only two brief case reports in the emergency medicine literature. The aim of this study was to investigate endothelial function and common carotid intima-media thickness (IMT) in healthy young men with mild-to-moderate hypertriglyceridemia. Mastocytosis is a general term for a heterogeneous group of rare disorders. Mechanically stable porous cellulose media for affinity purification of family 9 cellulose-binding module-tagged fusion proteins. Effects of maternal dietary zinc deficiency on prenatal and postnatal brain development were investigated in ICR strain mice. We believe that this method of visualizing and tracking chondrocytes may be useful in the further development of tissue engineered cartilage therapeutics. Prolactin and growth hormone cells in the human hypophysis: a study with immunoenzyme histochemistry and differential staining. The part of the ama1 gene covering domain I was PCR amplified and sequenced from 157 P.

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Thirty ureteric stones (in 20 subjects) were treated over a 2-year period. The renaissance of the sciences and medicine in the light of the suppression of the Jewish genius. CLA are much weaker radical scavengers as compared to vitamin E, vitamin C, and BHT. Tumorigenesis of murine erythroleukemia cell line transfected with exogenous p53 gene. canadensis accelerates, and the rate of photosynthesis increases. Here we describe the quantification of interleukin (IL)-2, IL-4, IL-10 and interferon-gamma (IFN-gamma) in human serum and peripheral blood mononuclear cell (PBMC)-conditioned medium by electrochemiluminescence method (ECL).

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Pliable metacrylate casts of blood vessels: use in a scanning electron microscope study of the microcirculation in rat hypophysis. This approach has great potential for simple, low-cost, and time-saving monitoring of microbial populations. To study the influence of Kai1/CD82 transfection on the growth, adherence, separation and invasion potential of LoVo colon carcinoma cell line. Complex longitudinal study of the physical and psychophysiological development of schoolchildren at different child and adolescent periods of ontogenesis. To determine the origin of fragments and to reveal the existence of new ions, the MS(3) capabilities of the system proved to be useful. Both attractive and repellent cues are required to guide developing axons to their targets in the central nervous system.

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In this way, many structural variations at the polymer terminus could be rapidly evaluated. Use of domperidone in the treatment of canine visceral leishmaniasis: a clinical trial. Based on the fact that the matrix vesicles were significantly enriched in free cholesterol, sphingomyelin, glycolipids and serine-phosphoglycerides, it is concluded that they are derived from the plasma membrane of the cell, supporting earlier conclusions based upon morphological and enzymological evidence. Bacterial cells were observed adhering to microvilli and to plasma membrane on both the apical and basal surfaces of the monolayer. Here, we examined WT1 genomic DNA in 38 cases of de novo non-small cell lung cancers (NSCLC) for mutations using direct sequencing. The sample stage was moved in 0.2 microm increments on a computer-controlled X-Y precision table. C1628 alone, or in combination with estradiol, does not have mitogenic effect on the mucosa, and in fact blocks the mitotic response normally induced by estrogen alone. Transposition of IS1397 in the family Enterobacteriaceae and first characterization of ISKpn1, a new insertion sequence associated with Klebsiella pneumoniae palindromic units. Functional characterization of the various mutants in the BDV minireplicon assay revealed that D substitutions at the CKII sites inhibited the polymerase-supporting activity of P, while A substitutions maintained wild-type activity.

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Adrenal, plasma and urinary corticosteroids during single or repeated administration of morphine in cats. Studies on the echolocation sound waves in different states (flying and hanging), morphological features and ecological processes (foraging strategies, foraging habitat and diet type) of Hipposideros pratti showed that H. Biochemical fractionation experiments showed that pp31 was localized in the nucleus and that it was more stably associated with the nucleus at later times of infection. Gastrin CCK(2) receptor antagonists and locally active agents appear to represent promising therapies for the future. Duplex sonography was performed in both injured and noninjured CCAs before and up to 14 days postinjury. Insulin treatment improves islet function in type 2 diabetic Chinese hamsters. Bayesian model averaging in time-series studies of air pollution and mortality. The research objectives were examination of the meanings of recurring key words and the role of language in the verbal interaction between educators and doctors in their daily professional life. We have developed the Fourier transform infrared spectral analysis system to measure constituents of human oral mucosa in vivo and clinically obtained serum for non-invasive diagnosis. This study did not support the hypothesis that early childhood infection as a consequence of overcrowding is an important factor in the development of RA.

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Tasks and relation of radiological microbiology to plans for economical development during 1959-65 in the USSR. The mean creatine kinase (MB fraction) at four hour to six hour after ablation was 40 U. Then, we injected fluorocitrate stereotaxicly into the dentate hilus to inhibit astrocytic metabolism and found that fluorocitrate failed to prevent the seizure-induced formation of ectopic hilar basal dendrites but instead promoted the degeneration of dentate granule cells after seizures. High-resolution immunostaining showed that TCL-1 was localized in both the cytoplasm and the nucleus. Lipophilic amino alcohols with calcium channel blocking activity. Early postpartum breastfeeding and acculturation among Hispanic women. The pediatric nurse practitioner can be instrumental in identifying these disorders and in making appropriate referral to a pediatric endocrinologist for further evaluation and treatment. Silver ion liquid-chromatographic mobility of plant diacylglycerols as a function of their composition and spatial arrangement. Locked intramedullary nailing in the treatment of femoral shaft fractures.

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The muscles are albenza annual cost located superficial to the medial part of the pectoralis major, arising from the sternum and are inserted into the sheaths of the rectus abdominis. Unilateral hippocampal and inferotemporal cortex lesions in opposite hemispheres impair learning of single-pair visual discriminations as well as visuovisual conditional tasks in monkeys. Pioglitazone is FDA approved for monotherapy as well as for use in combination therapy with metformin, insulin, or sulfonylureas. Letter: Effects pf pstmatal zinc deficiency on developing rat brain. In all cases the inactivators did not interfere with the response to interleukin 1 in human gingival fibroblasts. Good quantitation is achieved in the range of 0.033-2.5 mumoles of acetate per gram of liver or per milliliter of serum. We compute the regions of stable locking, which have a nontrivial shape in the plane of coupling strength versus frequency detuning. In all cases, contracture of the plantar skin at the base of the toe and tight FDB tendon were recognized to a variable degree.

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Under-served rural areas--home to over half of people in sub-Saharan Africa--bear a heavy HIV/AIDS burden. These in vitro experiments showed that the amylase activity was inhibited in the presence of these phytochemicals. This model provides the opportunity to investigate the effects of X-linked gene dosage/parent-of-origin effects on neurobiology in the absence of gross physiological abnormalities. Optimized growth conditions for direct amplification of cDNA clone inserts from culture. Polychlorinated biphenyls (PCBs) are lipophilic contaminants that may potentially affect mobilization of lipid reserves, increasing reliance on glycogen stores, which could otherwise be utilized to minocycline antibiotic side effects supply energy for gametogenesis. Central foveal thickness correlated negatively with visual acuity. Multi-disciplinary care plans--a key to reclaiming nursing passion. From the 48 Tunisian sporadic CRC cases analyzed, two patients showed somatic mutation of the MutYH gene.

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At 6 and 12 weeks, tensile tests were performed on fascicles from the tissue regenerated in the defect and the non-resected, residual tissue. In this study, the psychiatric side effects from isotretinoin were assessed in a larger group of BD patients than has previously been reported. It has been shown that distribution of the pharmacokinetic parameters in this sample tramadol hcl tab 100mg er can be assumed normal. To present unusual computed tomography (CT) findings concerning huge pneumatization of turbinates and paranasal sinuses in one patient. After pretreatment of mice daily with ginseng extract (GE) for 5 days, concomitant injections of MAP and GE suppressed the development of reverse tolerance to the effect of MAP, although GE itself did not affect the spontaneous motor activity of the naive mice. Bacterial DNA was extracted from the specimens and PCR analyses were carried out to detect 10 selected periodontopathic species using specific primers for each. The wide range of risk is quite important and might represent a substantial cost for the health system as well as for the society. Because of the continued high incidence of bronchopulmonary dysplasia, there is a renewed interest in non-invasive modes of ventilation like CPAP and nasal IPPV. Our findings highlight the value of screening for complex genomic rearrangements in searches for cancer-susceptibility genes. The material obtained from fine needle aspiration of the cyst demonstrated numerous detached ciliated tufts (DCTs) in a background of amorphous debris and degenerated cells.

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Sensitized mast cells were recovered from peritoneal cavities of rats, and purified by density gradient centrifugation with Percoll. The cytokines secreted by lung macrophages have been shown to play a critical role in the pathogenesis of silicosis, tumor necrosis factor-alpha (TNF-alpha), and transforming growth factor-beta1 (TGF-beta1) are prominent cytokines in silicosis, but the underlying mechanism remains to be determined. To define the role of polycystin-1 in formation of intercellular contacts and cell polarity during epithelial morphogenesis, we have utilized a 3D MDCK in vitro model of tubulogenesis and cystogenesis. The need to understand, mostly by the older patients, may differ depending on age and gender, but it always involves psychology. Patch-clamp recordings from these neurons show that superfusion with acetyl-L-carnitine (100-1000 microM) does not induce any membrane current. Short-term (as little as several days) feeding of an NC-inducing diet to female rats can lead to NC even if they are switched to an optimal diet. This docking reaction is insensitive to ATP(gamma s) but is blocked by ATP. This conclusion was supported by the finding that pulmonary gammadelta T cells, but not alphabeta T cells, isolated from mice that had resolved infection exhibited lung-homing capacity in both naive and infected recipients. Retrospective cohort study to assess if different patterns of Candida colonization determine different risks of progression to invasive fungal infection (IFI) in preterm neonates in NICU. Unfortunately, the poor sensitivity and the heavy weight of the collimator hamper the use of pinhole SPECT in animal studies by generating noisy and misaligned projections.

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Epidemiological profile of cutaneous leishmaniasis in an endemic region in the State of Rio de Janeiro, Brazil. Any inhibitory effect of G-CSF on the infarct lesion was found in the myocardial infarction reperfusion model rat, but only a small effect was found in rats with a complete ligation-induced myocardial infarction. N-Terminal sequencing, internal sequencing and amino acid analysis were used to identify twelve proteins of the human myocard two-dimensional gel electrophoresis (2-DE) pattern. Seasonal variation in stroke in the Hunter Region, Australia: a 5-year hospital-based study, 1995-2000. They have also been found to affect the growth, food intake and reproductive capabilities of animals. Diagnostic utility of white blood cell and differential cell counts. Aim of the study is to provide the orthognatic surgeon with anthropometric normal values based on a sample of aesthetically pleasant Italian subjects and to discuss the use of a simplified aesthetical analysis in the set-up of the surgical plan and in the evaluation of treatment outcome.

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After 29 Djungarian hamsters were intraperitoneally inoculated with 5 x 10(6) N. The crystal structure of CcCBM6 in complex with xylose showed that a tyrosine residue made hydrophobic contacts with the unsubstituted C5 atom of xylose and sterically hindered decorations at this sugar ring position. We interpreted the data as support for production-deficiency hypothesis. At adolescence, event-related potentials (ERPs) were recorded during a three-stimulus auditory novelty oddball task, which employed frequent standard and infrequent deviant tones as well as a set of complex, novel sounds. The selective antagonist at mGlu(5) receptors, SIB1893, did not prevent the suppression of adenosine sensitivity by DHPG. We assessed vasomotor function in systemic small arteries in CADASIL. Our large-scale cross-genome analyses, available as MYRbase, show that the functional spectrum of myristoylated proteins is currently largely underestimated. Whereas ecological risk assessments rely on standardized aquatic toxicity tests to assess ecological hazards, these techniques have limited utility for endocrine-active compounds, including select pharmaceuticals. In these cases, cross-sectional imaging plays an important role in the localization of the primary tumour, the detection of metastases, and the assessment of response to treatment. We therefore investigated the growth inhibitory effect of mesalazine on human colon cancer cells in vitro compared with established chemopreventive agents.

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