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Aplatin (Clopidogrel)
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Aplatin

Aplatin is a cheap, generically available blood thinner that prevents heart attack and stroke. For most patients, the typical dose of Aplatin is 75 mg by mouth once daily.

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Also known as: Clopidogrel

Description

Aplatin (clopidogrel) prevents platelets in your blood from sticking together to form an unwanted blood clot that could block an artery.

Aplatin is used to lower your risk of having a stroke, blood clot, or serious heart problem after you've had a heart attack, severe chest pain (angina), or circulation problems.

Dosage

Usual Adult Dose for Acute Coronary Syndrome:

Unstable Angina (UA)/Non-ST-Elevation Myocardial Infarction (NSTEMI): -Loading dose: 300 mg orally once -Maintenance dose: 75 mg orally once a day -Duration of therapy: Optimal duration unknown. ST-Elevation Myocardial Infarction (STEMI): -Loading dose: 300 mg orally once (OPTIONAL) -Maintenance dose: 75 mg orally once a day, with or without thrombolytics -Duration of therapy: Optimal duration unknown. Comments: -Administer this drug in combination with aspirin 75 mg to 325 mg orally once a day. -The benefit of this drug for patients who undergo primary percutaneous coronary intervention is unknown. Uses: Prevention of atherothrombotic events in patients with non-ST-segment elevation acute coronary syndrome (UA, NSTEMI, those who are to be managed medically, those who are to be managed with coronary revascularization) and STEMI.

Usual Adult Dose for Ischemic Stroke:

75 mg orally once a day Uses: Prevention of atherothrombotic events in patients with a history of recent myocardial infarction, recent stroke, or established peripheral arterial disease.

Usual Adult Dose for Myocardial Infarction:

75 mg orally once a day Uses: Prevention of atherothrombotic events in patients with a history of recent myocardial infarction, recent stroke, or established peripheral arterial disease.

Usual Adult Dose for Peripheral Arterial Disease:

75 mg orally once a day Uses: Prevention of atherothrombotic events in patients with a history of recent myocardial infarction, recent stroke, or established peripheral arterial disease.

Detailed Aplatin dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose can cause excessive bleeding.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Aplatin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Aplatin if you are allergic to Aplatin components. Do not take Aplatin if you're pregnant or you plan to have a baby, or you are a nursing mother. Be careful with Aplatin if you suffer from or have a history of stroke, stomach ulcer or ulcerative colitis; liver or kidney disease, hemophilia. Be careful with Aplatin if you are taking such medicines as aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs such as naproxen (Aleve, Naprosyn), diclofenac (Voltaren), diflunisal (Dolobid), etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ibuprofen (Motrin, Advil), (Toradol), ketoprofen (Orudis), nabumetone (Relafen), piroxicam (Feldene), ketorolac mefenamic acid (Ponstel), meloxicam (Mobic) and the others), phenytoin (such as Dilantin); torsemide (such as Demadex); medication used to prevent blood clots (alteplase (such as Activase), anistreplase (such as Eminase), dipyridamole (such as Persantine), streptokinase (such as Kabikinase, Streptase), ticlopidine (Ticlid) and urokinase (such as Abbokinase); fluvastatin (such as Lescol); a blood thinner (warfarin (such as Coumadin), heparin, ardeparin (such as Normiflo), dalteparin (such as Fragmin), danaparoid (such as Orgaran), enoxaparin (such as Lovenox), or tinzaparin (such as Innohep); tamoxifen (such as Nolvadex); tolbutamide (such as Orinase). It is not recommended to do sport while taking Aplatin because it can cause bleeding or bruising injury. If you are going to have a surgery you should stop taking Aplatin for 5 days before the surgery. Do not use potassium supplements or salt substitutes. If you want to achieve most effective results without any side effects it is better to avoid alcohol. Do not stop taking Aplatin suddenly.

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Advantages of the enlarged middle cranial fossa approach in acoustic neurinoma surgery. The NO-synthase activity and the rate of NO production in the rat aortic wall and cerebellum were 2-1.5-fold higher in the ISIAH rats than in normotensive WAG rat strain. Treatment of prolonged voiding dysfunction after tension-free vaginal tape procedure. This paper summarizes the most frequent causes of ocular and orbital pathologies which can be responsible for headaches and also provides a non-exhaustive overview of important intracranial and systemic pathologies causing headaches and ocular signs and/or symptoms. Two synthetically modified nucleoside triphosphate analogues (adenosine modified with an imidazole and uridine modified with a cationic amine) are enzymatically polymerized in tandem along a degenerate DNA library for the combinatorial selection of an RNAse A mimic. The most widely targeted tissue is skeletal muscle, because this strategy is not only promising for the treatment of muscle disorders, but also for the systemic secretion of therapeutic proteins. The value of gallium scanning in the evaluation of known cancer patients is exemplified by this patient.

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