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Apicord

Apicord comes as a tablet, a solution (liquid), an orally disintegrating tablet (tablet that dissolves quickly in the mouth) to take by mouth. It is usually taken once a day with or without food. Apriprazole also comes as a tablet that contains a sensor device to take by mouth to be used in adults to provide information about how the medication is taken.

Other names for this medication:
Apicord, Aridus, Arifril, Arilan, Arinex, Aripat, Aripicon, Aripiprazole, Aripra, Arpicin, Asprito, Biliff, Elrip, Pipra, Rizotal, Schizopra

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Also known as: Aripiprazole

Description

Aripiprazole is used alone or together with other medicines to treat mental conditions such as bipolar I disorder (manic-depressive illness), major depressive disorder, and schizophrenia. It is also used in children to treat irritability associated with autistic disorder and Tourette syndrome. Aripiprazole works in the brain to change how certain chemicals affect patients. It is an antipsychotic agent.

This medicine is available only with your doctor's prescription. Apicord® oral solution was withdrawn from the market on May 15, 2015 and this dose form is not marketed by any generic manufacturers.

Dosage

This section provides information on the proper use of a number of products that contain aripiprazole. It may not be specific to Apicord Discmelt. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

If you are using the orally disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not open the blister pack that contains the tablet until you are ready to take it. Remove the tablet from the blister pack by peeling back the foil, then taking the tablet out. Do not push the tablet through the foil. Do not break or split the tablet. Place the tablet in your mouth. It should melt quickly. After the tablet has melted, you may swallow or take a sip of water.

Swallow the tablets whole. Do not break, crush, or chew them.

Apicord Mycite® has a sensor in the tablet, which helps track it inside the stomach or bowels. The Apicord Mycite® System comes with a patch (wearable sensor), a smartphone application (app), and a web-based portal. Follow your doctor's instructions on how to use the medicine.

The Apicord Mycite® tablet is usually detected within 30 minutes after you take it, but there may be a delay of more than 2 hours for the smartphone app and web portal to detect that you have taken the medicine, and sometimes it might not be detected at all.

To apply the Apicord Mycite® patch:

The app will tell you when to apply or remove the patch. It should be changed weekly or sooner as needed. Place the patch to the left side of your body just above the lower edge of your rib cage. Do not put the patch in areas where the skin is scraped, cracked, inflamed, or irritated, or near the area where you had removed the previous patch. The app will help you place the patch in the correct location. You may keep the patch on when showering, swimming, or exercising.

Aripiprazole may be taken with or without food. If your doctor tells you to take it a certain way, follow your doctor's instructions.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (tablets and orally disintegrating tablets): For bipolar mania: Apicord® and Apicord Discmelt®: Adults—At first, 15 milligrams (mg) once a day. When it is given with lithium or valproate, the starting dose is 10 to 15 mg once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 30 mg per day. Children 10 years of age and older—At first, 2 mg once a day. The dose will be gradually increased to 10 mg once a day. Your doctor may adjust your dose again as needed. However, the dose is usually not more than 30 mg per day. Children younger than 10 years of age—Use and dose must be determined by your doctor. Apicord Mycite®: Adults—At first, 15 milligrams (mg) once a day. When it is given with lithium or valproate, the starting dose is 10 to 15 mg once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 30 mg per day. Children—Use and dose must be determined by your doctor. For depression: Adults—At first, 2 to 5 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 15 mg per day. Children—Use and dose must be determined by your doctor. For irritability in children with autistic disorder: Children 6 to 17 years of age—At first, 2 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 15 mg per day. Children younger than 6 years of age—Use and dose must be determined by your doctor. For schizophrenia: Apicord® and Apicord Discmelt®: Adults—At first, 10 to 15 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 30 mg per day. Children 13 to 17 years of age—At first, 2 mg once a day. The dose will be gradually increased to 10 mg once a day. Your doctor may adjust your dose again as needed. However, the dose is usually not more than 30 mg per day. Children younger than 13 years of age—Use and dose must be determined by your doctor. Apicord Mycite®: Adults—At first, 10 to 15 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 30 mg per day. Children—Use and dose must be determined by your doctor. For Tourette's disorder: Children 6 to 18 years of age—At first, 2 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 20 mg per day. Children younger than 6 years of age—Use and dose must be determined by your doctor.

Overdose

If you overdose Generic Apicord and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Apicord overdosage: drowsiness, vomiting, agitation, aggression, confusion, tremors, fast or slow heart rate, seizure, trouble breathing, feeling light-headed, or fainting.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Apicord MyCite dosage information

Side effects

The most common side effects associated with Apicord are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of aripiprazole in elderly patients who have schizophrenia, depression, or bipolar disorder. This medicine should not be used to treat behavioral problems in elderly patients who have dementia or Alzheimer disease.

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Peroral therapy of psoriasis using high doses of vitamin A palmitate. Authentic cell-specific and developmentally regulated expression of pro-opiomelanocortin genomic fragments in hypothalamic and hindbrain neurons of transgenic mice. Multivariable log-linear regression analysis was conducted for teen driver crashes to determine which characteristics were related to crashes resulting in a minor/moderate injury or serious injury to at least one vehicle occupant. Its medical applications offer numerous advantages and strengths, including ease of publication and access to large volumes of information. The results of the study highlight the challenge of taking psychosocial aspects of medical treatment sufficiently into consideration, given the ever increasing options for molecular genomic individualization. The dependence of action potential duration (APD) on the preceding diastolic interval (DI), i.e., restitution, has been purported to predict the development of alternans and reentrant arrhythmias. Some cells had the appearance of signet ring cells, some had hyperchromatic nuclei, and multivacuolated lipoblasts with hyperchromatic nuclei were observed throughout the lesion.

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Relationship between dynamic deformities and joint moments in children with cerebral palsy. In this paper the question is addressed whether bolalipids of different lengths or different headgroup structures can form mixed fibers. Moreover, when attending to faces, emotionally congruent bimodal stimuli were more efficiently processed than unimodal visual stimuli. Bifans that have OR gate configurations show rapid responses whereas AND gate bifans can introduce delays and allow prolongation of signal outputs. The cardinal aspect of the profile is intra-blood-brain barrier (BBB) IgG synthesis which can be qualitatively detected by determining unique CSF oligoclonal IgG bands and quantitated by rate formula, mg/day. Endothelial keratoplasty versus penetrating keratoplasty for Fuchs endothelial dystrophy. A general algorithm for peak-tracking in multi-dimensional NMR experiments. Controlling for sex, age, standing height, and body mass index, blacks had consistently lower levels of lung function for most measures.

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Lack of angiogenic activity is not due to an antiangiogenic factor(s) in the medium of these cells. The union of these two intermediates by means of a Julia-Kocienski coupling gave rise to a series of E-configured building blocks that did not prove amenable to transannular cyclization. Clinical evaluation was performed at preoperative level (T0), after 1 month (T1) and after 1 year (T2). The patient had no systemic signs of the disease, and was treated with localized radiation therapy. Combinations that produced maximal dopaminergic neuron survival are different from those that result in maximal differentiation and trophic factor response. The feline complex is clearly divided into morphological units, each containing a granular Callejal island and a population of satellite neurons. Stability of negative ionization fronts: Regularization by electric screening?.

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Physiopathology of heart failure: experimental model and therapeutic effects. We describe the clinical course of the early postoperative period in a patient coinfected with HIV and hepatitis C virus undergoing liver transplantation. Prostaglandin E2 suppositories as a second-trimester abortifacient. Computational observation of pockets of enhanced pepcid otc mg water concentration at the 1-octanol/water interface. Two new ent-labdane glycosides, one known furano-ent-labdane and a new hydroxylated fatty acid were isolated from the dichloromethane extract of the freshwater aquatic plant Potamogeton lucens. Large-scale phase-field simulations of the ideal grain growth in two-dimensions (2D) and three-dimensions (3D) were carried out with holding the coalescence-free condition, where a few tens of thousands grains evolved into a few thousand grains. The 5-HT(7) receptor antagonist, SB-269970-A, significantly inhibited 5-HT efflux. An autopsy revealed that the tumor was present at the right pleura and invaded the right upper lobe of the lung and the mediastinum. A careful examination of the ultrasound parameters that elicited these observed effects is needed so that one may refine and apply these results for clinical application.

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To study if these what class of medication is plavix mechanisms are affected by estrogens, pituitary-grafted (GRAFT) and sham-operated (SHAM) rats were injected with a single dose of estradiol benzoate (EB), their plasma PRL levels as well as their hypothalamic and AP contents of norepinephrine (NE) and dopamine (DA) being analyzed. The influence of sex and age on membrane fluidity, has been investigated in 6, 12, 18 weeks old Sprague-Dawley rats. Butyltin compounds were detected from all the stations covering 640 km(2) of an enclosed bay system. Frying of chicken legs was conducted at 100 and 150 degrees C for 15 min and at 200 degrees C for 5, 10, and 15 min. Modulation of sensory inhibition in the ventrobasal thalamus via activation of group II metabotropic glutamate receptors by 2R,4R-aminopyrrolidine-2,4-dicarboxylate. TCM therapy for smoothing Gan-qi shows good efficacy with quick initiating and high safety, it is an important principle for the treatment of CP/CPPS. Changes in rugae positions during the observation period were measured with respect to the palatal plane. As a technically simple and an effective genetic tool which can exert effect on the expression of gene and substitute for gene knock-out technique in some degree, RNAi phenomena have been broadly validated in diverse model organisms such as Caenorhabditis elegans, Drosophila melanogaster, Arabidopsis thaliana and Neurospora crassa. In this paper, we proposed a kind of phosphor coating method to enhance ACU of phosphor-converted white LEDs with conventional chips by the combination of substrate structure design and phosphor dip-transfer coating. pylori infection status was determined by a validated serological test.

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To some extent, they are able to regulate the imbalance between ET and NO content under the condition of HLP. Novel nonsteroidal inhibitor of cytochrome P450(17alpha) (17alpha-hydroxylase/C17-20 lyase), YM116, decreased prostatic weights by reducing serum concentrations of testosterone and adrenal androgens in rats. In conclusion, the combination treatment of ART and OSI-774 resulted in an increased growth inhibition of GBM cell lines as compared to each drug alone. However, the emission coupled to the plasmonic modes must then be outcoupled into the far field before it succumbs to ohmic losses. The organ extraction and splanchnic haemodynamic effects of octreotide in cirrhotic patients. Non-Traditional Sites for Vascular Anastomoses to Enable Kidney Transplantation in Patients with Major Systemic Venous Thromboses. Current practice in ASPs is sufficient to meet LVPA policies/standards but insufficient to meet MVPA policy/standards. Previous studies compared uptake by dendritic cells (DC) of 20, 40, 100, 200, 500, 1000, and 2000 nm beads in vivo. However, immunological detection of the ToANV CPs in the agroinfiltrated areas showed that this mutant was not detected in the sieve elements even if the surrounding parenchymatic cells were ToANV positive, suggesting a role for the RNA2-ORF1 protein in processes occurring prior to phloem uploading, including efficient what is the generic form of zetia spread in inoculated leaves. Growth changes in children and adolescents with short-term diabetes.

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Myelodysplastic syndromes: state of the art pathology, diagnosis and management. These proteins, especially GMF beta, may be involved in an inhibition process of IFN beta-1a on activation and apoptosis of LX-2 cells. Histidine tested in parallel with histamine showed no activity on this model. Ultrastructural examination showed some subependymal neurons with pyknotic nuclei, reduced cytoplasmic volume, and swollen subcellular organelles, while others had fragmented and condensed nuclear material. Mean systolic pressure differences, volume losses, and energy losses, as well as dimensionless pressure losses and energy loss coefficients, are calculated from the recorded pressure, volume, and flow tracings. This purpose of this study was to analyze the computed tomography (CT) findings of hepatocellular carcinoma (HCC) with bile duct tumor thrombus (BDTT) and explore their correlations with pathological manifestations. Only complications were 4 cases of pneumonia, 1 case of wound leakage, and 1 case of superficial wound infection.

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Secreted proteins from cultured rat Sertoli cells were assessed for effects on phytolectin-stimulated rat splenic lymphocytes. During admission, the demographic data, vascular risk factors, stroke features, and neurological status information were collected. Thus, the aim of this study was to measure marA expression in ciprofloxacin resistant E. Multiomics Analysis of Tumor Microenvironment Reveals Gata2 and miRNA-124-3p as Potential Novel Biomarkers in Ovarian Cancer. Species recognition of congeneric acanthocephalans in slider turtles by random-amplified polymorphic DNA (RAPD) markers. The eagerly awaited seventh version of the Declaration of Helsinki (DoH) was released by the World Medical Assembly (WMA) on October 19, 2013 at the 64th General Assembly. Such peptide nanoparticles are ideally suited for medical applications such as drug targeting and drug delivery systems, such as imaging devices, or they may be used for repetitive antigen display. Multilocus sequence typing implicates rodents as the main reservoir host of human-pathogenic Borrelia garinii in Japan. Seven of them thereafter received alpha-calcidol (a synthetic analogue to active vitamin D) intravenously for three months.

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Reasonable agreement between computed and available experimental data was found in terminal cluster size distributions for nozzle water expansions in a wide range of stagnation pressures. Pyrazinamide plasma concentrations in young children with tuberculosis. In patients with chronic renal failure and end-stage renal disease plasma concentrations of Ba and activated C3 were markedly elevated independent of hemodialysis. Searching binary sequences for coded excitation in medical ultrasound. To systematically evaluate the effect and safety of acupuncture in the treatment of vascular mild cognitive impairment (VMCI). The CRP measurement by ultrasensitive method is suitable for cardiovascular risk estimation in apparently healthy men and women. In the own study on perfused human placental cotyledon, only toxic concentrations of valproic acid caused morphological changes in placental tissue, including microvascular degeneration of cytoplasm, atrophy of syncytiotrophoblast, colliquative necrosis of some mesenchymal cells. The primary CV test battery includes an evaluation of proarrhythmic risk using in vitro tests (hERG channel and Purkinje fiber assays) and in vivo measurements in conscious animals via telemetry. Identification of human exercise-induced myokines using secretome analysis.

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Although evidence of the beneficial action of hypertonic saline solutions in traumatic brain injury is robust, data supporting use in other conditions are only now mounting. Circular dichroic and kinetic differentiation of DNA binding modes of distamycin. Membrane binding and oligomer membrane insertion are necessary but insufficient for Bacillus thuringiensis Cyt1Aa toxicity. In continuation, the present study investigated which specific opioid receptors-mu, delta or kappa-mediate the observed YFa antinociception pharmacologically using specific antagonists and whether chronic administration of YFa at 26.01 micromol/kg per day induces tolerance and its effect on the expression of mu and kappa opioid receptors from day 4 to day 6, with endomorphine-1 (EM-1) and saline taken as positive and negative controls, respectively. Recently, several works have reported facile sonochemical method of functionalizing nanoparticles with organic coupling agents. Our report suggests that cases of mild SLO remain undiagnosed and untreated, and that awareness of this common cause of mental retardation is low zithromax 1000 mg . This paper reviews and discusses the analytical combination of ionic liquids (IL) with CE. Experimental results were consistent with theoretical prediction. Acquired immunodeficiency syndrome/human immunodeficiency virus knowledge, attitudes, and practices, and use of healthcare services among rural migrants: a cross-sectional study in China. Treatment of complete genital prolapse by sacrospinous fixation, anterior mesh repair and conservation of the uterus.

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