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Apgel (Adapalene)
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Apgel

Apgel is used to treat acne. It may decrease the number and severity of acne pimples and promote quick healing of pimples that do develop. Apgel belongs to a class of medications called retinoids. It works by affecting the growth of cells and decreasing swelling and inflammation.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

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Also known as: Adapalene

Description

Apgel (adapalene) is a topical medicine (a medication that is applied to the surface of the skin) similar to vitamin A. It helps the skin to renew itself.

Apgel is used to treat severe acne in people who are at least 12 years old. It works by decreasing acne formation.

Dosage

Follow the directions for using this medicine provided by your doctor. Use Apgel exactly as directed. Apgel is best applied after washing and drying your skin. Apply a thin layer of gel to the affected areas once daily at bedtime. Avoid the eyes, lips and nose. Do not allow this preparation to come into contact with the mucous membranes (e.g. mouth, vagina, inside of nose etc.). Try not to touch the treated areas overnight. Do not use any harsh soaps or exfoliants while you are being treated with Apgel. Apgel should not be used on broken, sunburnt or infected skin. You may notice a slight change of colour of the skin you are applying this preparation to. This is only temporary and should return to normal soon after finishing treatment with Apgel. Continue using Apgel until no new acne spots appear. You may need to use it for several months. You should notice some clinical improvement after 4-8 weeks and more improvement after further use. There may be a worsening of acne during the first few weeks of therapy because Apgel promotes the growth of pimples that have begun to form but are not yet visible. Therefore, treatment should not be stopped if acne appears to be worsening. Use a sunscreen cream and wear protective clothing if exposure to strong or prolonged sunlight cannot be avoided. Weather extremes such as wind or cold may also be irritating.

Overdose

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include skin redness, scaling, or irritation.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Apgel dosage information

Side effects

The most common side effects associated with Apgel are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

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In a population based case series of 551 patients with malignant melanoma of the skin diagnosed in the period 1982 to 1985 collected as part of a population-based case-control study, the specific anatomic site of the primary lesion was recorded, and the lesions were classified as to histologic subtype. Autophagy is a highly conserved cellular mechanism in eukaryotes allowing the degradation of cell constituents. Cell counts obtained by this method were compared to viable cell counts by agar plate counting, revealing accurate correlation. Although modern immunosuppression regimens have effectively handled acute rejection, nearly all organs except the liver commonly suffer chronic immunologic damage that impairs organ function, threatening patient and allograft survival. The objective of this study was to determine whether lower expression levels of DICER1 are associated with disease recurrence in patients with endometrioid endometrial cancer. A 28-year-old farmer suffered a corneal perforation with a piece of wire in the right eye. A wavelength-based surface plasmon resonance (SPR) technique has been used for the measurement of glucose concentration in aqueous solution. More than 700 oil wells were set on fire, emitting thousands of tons of oxides of nitrogen, sulfur, soot and oil mist at high temperatures. Activating adaptive cellular mechanisms of resistance following sublethal cytotoxic chemotherapy: implications for diagnostic microdosing. These results substantially contradict longstanding theory, catalyzing both novel perspectives and new approaches in dosage compensation research.

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Molecular design and morphology control towards efficient polymer solar cells processed using non-aromatic and non-chlorinated solvents. When changes in the chromatin states are inherited trough mitotic or meiotic cell division, the mechanisms responsible for these changes are defined as epigenetic. Induced formation of phenylalanine ammonia lyase and pisatin by chlorpromazine and other phenothiazine derivatives. The effect of the tolerance induction protocol on the anti-alphaGal antibody response has been assessed. This study investigates how children with ASD access and select meanings of ambiguous words to test four hypotheses regarding the nature of their comprehension difficulties: semantic deficit, weak central coherence, reduced top-down control and inhibition deficit. Nitidine chloride induces apoptosis and inhibits tumor cell proliferation via suppressing ERK signaling pathway in renal cancer. We then examined the effectiveness of reminiscence group therapy on depressive symptoms and cognitive function in this population. There is good evidence that topical mupirocin and topical fusidic acid are equally, or more effective than oral treatment for people with limited disease. Perialar semilunar excision and malignant tumors of the upper lip.

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To estimate the time veterinary graduates spend in private practice and in veterinary work generally, and to determine what factors influence this. Using 1512 subjects from a hospital-based study, we sought to describe the demographic and clinical characteristics of poisoning patients and to identify predictors for poisoning-related fatality. Although alcohol abuse is known to create a variety of adverse effects on hematopoiesis, the associations between ethanol consumption and hematological abnormalities have not been fully established. Patient selection for spinal cord stimulators: mental health perspective. Optokinetic deficits in albino ferrets (Mustela putorius furo): a behavioral and electrophysiological study. Long-term outcome of tacrolimus rescue therapy in late rejection after renal transplantation. To overcome these challenges, we have developed a novel three-dimensional vasculature segmentation method based on local clustering and classification. Two new studies appearing albendazole oral suspension in this issue of Developmental Cell implicate the small GTPases Ran and Rac in cortical polarity of the mouse egg. APRIL likely exerts its effects on peritoneal B-1 cells through binding to HSPG (heparan sulfate proteoglycans) rather than to the TACI (transmembrane activator and cyclophilin ligand interactor) receptor. Interferon-alpha (IFN-alpha) often causes severe depression in patients treated for chronic viral hepatitis and certain malignancies.

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This paper presents the recommendations of the American Association of Physicists in Medicine (AAPM) and the European Society for Therapeutic Radiology and Oncology (ESTRO) on the dosimetric parameters to be characterized, and dosimetric studies to be performed to obtain them, for brachytherapy sources with average energy higher than 50 keV that are intended for routine clinical use. SOCS box deletion mutants of SOCS1 and SOCS3 were severely hampered in their abilities to inhibit STAT activation and to efficiently suppress colony formation by primary myeloid progenitors in response to G-CSF. Oral preadministration of ONO-8130 at 0.3-30 mg/kg strongly prevented both the bladder pain-like behavior and referred hyperalgesia in a dose-dependent manner, but had slight effect on the increased bladder weight and vascular permeability. This article comprehensively reviews the literature on the epidemiology, etiology, evaluation, and treatment of interstitial cystitis, and considers commonly associated pelvic floor dysfunction. the non-uniform distribution and unknown topology, an implicit surface model is adopted based on radial basis functions network. Anti-inflammatory potential of native Australian herbs polyphenols. Antiphospholipid Syndrome (APS), a thrombophilic condition, is being increasingly recognised as an important cause of recurrent pregnancy loss, preeclampsia and possible infertility. Without SOCS3, signal transducer and activator of transcription 3 (STAT3) phosphorylation is prolonged, and activation of the mitogenic extracellular signal-regulated kinase 1/2 (ERK1/2) is enhanced after PH. Associations between various clinicopathological factors and the presence of lymph node metastasis were analyzed to identify the risk factors of lymph node metastasis.

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