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Anxidep (Imipramine)

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Anxidep works by inhibiting the reuptake of certain neurotransmitters in the brain, including acetylcholine, dopamine, norepinephrine, and serotonin. It also acts on certain other receptors, such as H1 receptors for histamine. Anxidep usually is administered orally but may be given by intramuscular injection.

Other names for this medication:
Antipres, Anxidep, Anxitab, Anxofit, Depforte, Depik, Depof, Depranil, Depsin, Depsol, Depsolam, Depsonil, Diamin, Diazariv, Elamin, Eldep, Elidep, Endopax, Estidep, Finezol, Imikon, Imilor, Imipam, Imodep, Impranit, Imprax, Imprim, Imprin, Karthin, Lastinem, Libomin, Nimipose, Normadep, Prazep, Talendep, Toframine, Trydep, Ultradep

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Also known as: Imipramine


Anxidep is a tricyclic antidepressant used to treat symptoms of depression. This medicine is sometimes used to treat bed-wetting in children ages 6 and older.


This section provides information on the proper use of a number of products that contain imipramine. It may not be specific to Anxidep-PM. Please read with care.

Take this medicine only as directed by your doctor to benefit your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (capsules): For depression: Adults—At first, 75 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 200 mg per day, unless you are in the hospital. Some hospitalized patients may need higher doses. Teenagers and older adults—At first, 25 to 50 mg per day using the tablets. Your doctor may adjust your dose as needed and switch you to the capsule form. However, the dose is usually not more than 100 mg per day. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets): For depression: Adults—At first, 75 milligrams (mg) per day. Your doctor may adjust your dose as needed. However the dose is usually not more than 200 mg per day. Some hospitalized patients may need higher doses. Teenagers and older adults—30 to 40 mg per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 100 mg per day. Children—Use and dose must be determined by your doctor. For enuresis (bedwetting): Children 6 years of age and older—At first, 25 milligrams (mg) once a day, taken 1 hour before bedtime. Your doctor may adjust the dose as needed. Children younger than 6 years of age—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Anxidep can be fatal.

Overdose symptoms may include irregular heartbeats, feeling like you might pass out, seizures, or coma.


Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

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The most common side effects associated with Anxidep are:

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Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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Free radical scavengers were used to assess the role of reactive oxygen species (ROS) in these pathways. With this treatment, there is less need for a second operation, and an additional operation is not necessary for soft tissue coverage. Multiple organ dysfunction syndrome (MODS) induced by sepsis involves to a series of gene differential expressions, such as cell cycle and control related genes, cell apoptosis genes, immunity related genes, genes concerning energy metabolism, blood system related genes, cancer related genes, growth factor genes, acute stress reaction related genes etc. On the basis of the literature and our own experience we designed a flow chart for the management of pancreatic injuries. These results suggest that optical correction of astigmatism should be provided prior to age three to five years, to prevent development of amblyopia. The use of glass-ionomer cement rather than composite cement as the luting material resulted in more microleakage. L-NAME (50 mg/kg) was given by an intraperitoneal (i.p.) injection 30 min before oxytocin administration (experiment 2) or an i.p.

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Time-dependent regulation of rat adipose tissue glucose transporter (GLUT4) mRNA and protein by insulin in streptozocin-diabetic and normal rats. Educational achievement, employment and living situation in long-term young adult survivors of childhood cancer in the Netherlands. Our results showed a tissue-specific regulation of this protein: Ob-Rb expression in the adipose tissue decreased when the time of treatment or the dose of estradiol administered increased, suggesting less sensitivity to leptin in this tissue, whereas in the skeletal muscle the changes in this protein followed the same profile as the plasma leptin levels. The implications for primary health care delivery and education are considered. To investigate the influence of cervical sympathetic nerve block (SB) on blood flow volume and barrier function of intestinal mucosa after combined radiation and burn injury in rat. This prospective, single-center, cohort study characterized ambulatory blood pressure monitoring as an early pharmacodynamic biomarker of VEGF signaling pathway inhibition by sorafenib. The diphtheria toxin T domain helps translocate the A chain of the toxin across membranes.

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Evaluation of endovenous radiofrequency ablation and laser therapy with endoluminal optical coherence tomography in an ex vivo model. The OMWQ-HN, along with the Functional Assessment of Cancer Therapy-Head and Neck (FACT-HN), was administered 5 times over an approximately 6-week period to patients with head and neck cancer (HNC) who were receiving radiation therapy with or without chemotherapy. Antibodies to Scl1.1 protein were detected in human sera from healthy individuals previously infected cordarone 200 mg 30 tab with M1 GAS and from patients with various GAS infections, as well as in sera from mice infected with M1 GAS. Vitamin E supplementation of 800 IU daily normalized the lipid peroxidation products but did not significantly change serum lipids. The log-rank test and multivariate Cox proportional hazard models were used to identify the prognostic factors predicting for survival.

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We corroborate in Long-Evans animals the greater rotation of females, but our findings oppose the right-sided female and left-sided male rotational preferences reported in earlier studies. The method was evaluated both in phantoms and in vivo in a delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) study with 33 subjects. Dietary n-3 polyunsaturated fatty acids decrease hepatic triglycerides in Fischer 344 rats. TNFalpha blockade induced restoration of the Th1 cytokines, resulting in a normal cytokine balance. COX-2 specific inhibitors: are NSAIDs and the stomach become reconcilied?. Concerns about toxicity, delayed onset of action, and therapeutic failure (1 out of 3 patients) have restricted their use. Three-dimensional reconstructions of the fluorescence absorption from the dual point illumination geometry compare well with the reconstructions from the single point illumination geometry.

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Under conditions of excess sunlight the efficient light-harvesting antenna found in the chloroplast membranes of plants is rapidly and reversibly switched into a photoprotected quenched state in which potentially harmful absorbed energy is dissipated as heat, a process measured as the non-photochemical quenching of chlorophyll fluorescence or qE. Surface plasmon resonance using soluble wild-type LFA-1 and an IDAS mutant of LFA-1 indicate that the IDAS can regulate a 6-fold change in the K(d) of ICAM-1 binding. This is the first non-primate example of specialization in policing tasks without direct selfish interests. Fecal markers are non-invasive, simple, cheap, sensitive and specific parameters and are useful to detect strointestinal inflammation. Structure, process and outcome asacol hd 800 mg discount coupon as part of quality assurance is defined as well as criteria, standards and norms.

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A range of kinematic conditions occurs at the tibio-femoral interface, giving rise to various degrees of rolling and sliding at this interface. Measurement of interrupter resistance (Rint) requires only tidal breathing from the patient and therefore, can be used as a lung function test for preschool children. The adaptive component of innate immunity occurs during the course of infection when antigen presenting cells alter expression of soluble or surface associated pattern recognition receptors. Embryonic development in solitary ascidians is the classic example of determinative specification, and we are interested in both the origins and the persistence of stem cells responsible for asexual development in colonial ascidians. Oral vaccination against diphtheria using polyacryl starch microparticles as adjuvant. Effect of gonadectomy on the metabolism of arachidonic acid in isolated kidney of a rat model of metabolic syndrome.

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Correlations between age, phenotype, and individual contribution to population growth in common terns. Interestingly, the early upregulation of IFN-gamma gene transcription, which was observed after infection with Salmonella, was reproducibly delayed in susceptible mice compared to resistant cost of sustiva mice. Lipolytic enzymes may play a role in the pathogenesis of acute pancreatitis. We propose that the GAT domain is descended from the same ancestor as the syntaxin 1a N-terminal domain, and that both protein families share a common function in binding coiled-coil domain proteins. The present data strongly suggest that LUTS are associated with chronic ischaemia of the prostate and urinary bladder. The role of growth hormone and prolactin in beta cell growth and regeneration.

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