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Anerobia (Metronidazole)

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Anerobia is a medicine used to treat different types of bacterial and parasitic infections, including those that affect the skin, vagina, blood, heart, bone, stomach, liver, joints, nervous system, respiratory tract, and other areas of the body.

Other names for this medication:
Amobin, Anabact, Anaerobex, Avidal, Bemetrazole, Birodogyl, Clont, Colpofilin, Deflamon, Dirozyl, Efloran, Elyzol, Etron, Filmet, Flagicure, Flagystatin, Flazol, Fortagyl, Gynoplix, Mebadiol, Mecozol, Menizol, Metrazol, Metren, Metronide, Metropast, Metrosa, Metroson, Metrozol, Metsina, Monizole, Nidazole, Nidazyl, Orogyl, Otrozol, Padet, Rhodogil, Tolbin, Trichozole, Tricodazol, Trogyl, Unigyl, Vagilen, Vertisal

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Also known as: Metronidazole


Anerobia (generic name: Metronidazole) is an antibiotic that belongs to a group of medicines called nitroimidazoles.

Anerobia is used for the treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions: amebiasis, symptomatic and asymptomatic trichomoniasis; skin and skin structure infections; CNS infections; intra-abdominal infections (as part of combination regimen); systemic anaerobic infections; treatment of antibiotic-associated pseudomembranous colitis (AAPC); bacterial vaginosis; as part of a multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer recurrence.


This section provides information on the proper use of a number of products that contain metronidazole. It may not be specific to Anerobia. Please read with care.

Use this medicine exactly as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered.

This medicine is to be used only in the vagina. Use it at bedtime, unless your doctor tells you otherwise.

Do not get it into your eyes, nose, mouth, or skin. If this medicine does get into your eyes, wash them out right away with large amounts of cool tap water. If your eyes still burn or are painful, check with your doctor.

This medicine comes with a patient information leaflet and patient instructions. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Wash your hands with soap and water before and after using this medicine.

Nuvessa™ is available inside a prefilled applicator. The applicator is open at one end where you will insert the plunger and has a pink cap on the other end where the medicine will come out.

Vandazole® is in a tube. You will use an applicator to put the gel into your vagina. The applicator has a plastic tube called a barrel that is open at one end and has a plunger (another piece of plastic that can move inside the barrel) at the other end.

To use the medicine:

To fill the applicator: For cream or gel dosage forms: Nuvessa™: With the pink cap still on, push the tip of the plunger into the open end of the prefilled applicator. Pull the cap off before you insert the applicator into your vagina. Vandazole®: Break the metal seal at the opening of the tube by using the point on the top of the cap. Screw the applicator onto the tube. Squeeze the medicine into the applicator slowly until it is full. Remove the applicator from the tube. Replace the cap on the tube. For vaginal tablet dosage form: Place the vaginal tablet into the applicator. Wet the vaginal tablet with water for a few seconds. To insert vaginal metronidazole using the applicator: For all dosage forms: Relax while lying on your back with your knees bent (or in any position that you feel comfortable). Hold the full applicator in one hand. Insert it slowly into the vagina. Stop before it becomes uncomfortable. Slowly press the plunger until it stops. Withdraw the applicator. The medicine will be left behind in the vagina. Remove the applicator from your vagina. Use each applicator only once, and then throw it away.

To help clear up your infection completely, it is very important that you keep using this medicine for the full time of treatment, even if your symptoms begin to clear up after a few days. If you stop using this medicine too soon, your symptoms may return. Do not miss any doses. Also, continue using this medicine even if your menstrual period starts during the time of treatment.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For bacterial vaginal infections: For vaginal dosage form (cream): Adults—One applicatorful (500 milligrams [mg]), inserted into the vagina. Use the medicine 1 or 2 times a day for 10 or 20 days. Children—Use and dose must be determined by your doctor. For vaginal dosage form (gel): Nuvessa™: Adults and children 12 years of age and older—One applicatorful (5 grams [g]) inserted into the vagina once (at bedtime). Each applicatorful of Nuvessa™ contains 65 mg of metronidazole. Children younger than 12 years of age—Use and dose must be determined by your doctor. Vandazole®: Adults—One applicatorful (5 grams [g]) inserted into the vagina once a day (at bedtime) for 5 days. Each applicatorful of Vandazole® contains 37.5 mg of metronidazole. Children—Use and dose must be determined by your doctor. For vaginal dosage form (tablets): Adults—One 500 milligram (mg) tablet, inserted high into the vagina. Use the medicine once a day in the evening for 10 or 20 days. Children—Use and dose must be determined by your doctor.


Single oral doses of Anerobia, up to 15 g, have been reported in suicide attempts and accidental overdoses. Symptoms reported include nausea, vomiting, and ataxia. Oral Anerobia has been studied as a radiation sensitizer in the treatment of malignant tumors. Neurotoxic effects, including seizures and peripheral neuropathy, have been reported after 5 to 7 days of doses of 6 to 10.4 g every other day.

There is no specific antidote for Anerobia overdose; therefore, management of the patient should consist of symptomatic and supportive therapy.


Store at room temperature below 25 degrees C (77 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Anerobia are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Anerobia if you are allergic to metronidazole, secnidazole, or tinidazole, or if:

you recently drank alcohol; or you took disulfiram (Antabuse) within the past 14 days.

Do not take metronidazole during the first trimester of pregnancy. This medicine can harm an unborn baby. Tell your doctor if you are pregnant.

To make sure Anerobia is safe for you, tell your doctor if you have ever had:

liver disease; kidney disease (or if you are on dialysis); a heart rhythm disorder; Cockayne syndrome (a rare genetic disorder); a stomach or intestinal disease such as Crohn's disease; a blood cell disorder such as anemia (lack of red blood cells) or low white blood cell (WBC) counts; a fungal infection anywhere in your body; or a nerve disorder.

In animal studies, metronidazole caused certain types of tumors, some of which were cancerous. However, it is not known whether these effects would occur in humans. Ask your doctor about your risk.

You should not breastfeed within 24 hours after using Anerobia. If you use a breast pump during this time, throw out any milk you collect. Do not feed it to your baby.

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Phase transfer surfactant-aided trypsin digestion for membrane proteome analysis. Adult-generated granule cells (GCs) in the dentate gyrus must establish synapses with preexisting neurons to participate in network activity. AR immunoexpression was found in new LCs on day 14 and 21 after EDS injection with an increasing curve of intensity. Conditioned taste aversion induced by motion is prevented by selective vagotomy in the rat. We investigated the effect of CRT optimization on LAP and its waveform parameters in ambulant heart failure (HF) patients. We report case of 47 years old man with pelvic hemangiopericytoma and discuss imaging studies and pathohystological findings. It is felt that this understanding would facilitate well designed investigations ultimately leading to higher quality practice of ophthalmology in our country. The Utility of a Wireless Implantable Hemodynamic Monitoring System in Patients Requiring Mechanical Circulatory Support.

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Identification of the phenolic substances in bovine urine associated with oak leaf poisoning. Polymerase chain reaction (PCR) followed by digestion with HaeIII and MspI endonucleases (RFLP) were applied to detect intron 1 and exon 1 polymorphisms, respectively, in a total of 125 controls and 105 affected women. Co-immunoprecipitation showed that MLL5 preferentially interacted with the tetramerized form of p53, and knockdown of MLL5 promoted chromatin accumulation of p53 tetramers, suggesting that the association of MLL5 with p53 may prevent the p53 tetramers from binding to the chromatin target sites. Intrinsic control of precise dendritic targeting by an ensemble of transcription factors. Velocity change (delta-V) is the major descriptor of collision severity used in most real-world crash databases.

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Radical retropubic prostatectomy combined with adjuvant and salvage treatments demonstrated a satisfactory outcome for pT3b prostate cancer. Prognostic value of asymptomatic skin sensitization to aeroallergens. Living-donor right hepatectomy with or without inclusion of middle hepatic vein: comparison of morbidity and outcome in 56 patients. Due to the unique properties of synchrotron light, SR biomedical imaging can provide information that conventional X-ray imaging is not able to capture. These two domains adopt an unusual antiparallel arrangement that has not been reported in tandem repeats of immunoglobulin-like domains and that is presumably conserved in all type IIa receptor protein tyrosine phosphatases. Furthermore, activation of ERK5 may provide a novel therapeutic target to improve long-term memory. The RTA scans an obliquely oriented slit laser beam across the macula to obtain a series of optical cross sections, which are digitized. Polyhydroxyalkanoates (PHAs) have received much attention in the current scenario due to their attractive material properties, namely biodegradability, biocompatibility, thermoplasticity, hydrophobicity, piezoelectricity and stereospecificity. It is shown by means of measurements performed on an olive oil sample that the fluorescence background can be greatly suppressed if the sample response is recorded only for photons coinciding with the laser pulse. Here, we show that these cells possess an additional function as professional antigen-presenting cells capable of priming a T(h)1- and T(h)17-acquired immune response.

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Heavy meromyosin binding to microfilaments involved in cell does diflucan help yeast infection and morphogenetic movements. PKA/KIN-1 mediates innate immune responses to bacterial pathogens in Caenorhabditis elegans. Insulin-like growth factor I (IGF-I), a potent proximal tubule cell (PTC) mitogen, has been implicated in the progression of many human cancers. Substitution of cysteine 435 reduced the steady-state level of CLN3 in lysosomes most likely because of impaired sorting in early endosomal structures, particularly in neuronal cells. Gold particles are also detectable, in aggregates or patches, in proximity of or in association with, cytoskeletal elements tentatively identified with microfilaments (MF) present in the growth cone and microtubules (MT) running in parallel within the neurites or present in the perikaryon. High-spin cyclopentadienyl complexes: a single-molecule magnet based on the aryl-iron(II) cyclopentadienyl type.

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Alanine replacements are prepared by site-directed mutagenesis to produce the inactive E138A and E134A mutants. So, different disulfide bonds in glycoproteins of native viral particles differ in their sensitivity to the reductant. To identify the independent variables associated with dental health services utilization, two types of multivariate regression models were used, according to the measurement scale of the outcome variable: a) frequency of utilization as (0) none, (1) one, and (2) two or more, analyzed with the ordered logistic regression and b) the type of service utilized as (0) none, (1) preventive services, (2) curative services, and (3) both services, analyzed with the multinomial logistic regression. Sex hormones and gender differences are associated with the occurrence of ventricular arrhythmias. We report on penile ulcus as a complication of self-induced papaverine erections in 2 patients. Campylobacter concisus is an emerging enteric pathogen, yet it is commonly isolated from feces and the oral cavities of healthy individuals. A new variable predictive model based class discrimination (VPMCD) method is described here. Prominent alveolar fibrin deposition was observed within 2 h after oleic acid-induced lung injury.

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The aim of this study was to understand the current status of preterm birth in native Tibetan women and investigate the socioeconomic and environmental determinants. Serum AHSG in women has been reported to decrease after menopause and increase with estrogen therapy. We demonstrate that the global activity can be shifted between regions by changing either the density of ion channels at the subcellular level, or the connectivity at the network level, suggesting that different underlying mechanisms can explain similar global phenomena. We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of non-drug preventive interventions in non-pregnant adult travellers?. The remaining four receptive field types-which share the property of having radially asymmetric fields-appear later, coincident with a decline in the percentage of cells that are visually responsive but not classifiable as to receptive field type. An online database for the detection of novel archaeal sequences in human ESTs. tHcy seems to be a predictor for hip fracture among elderly men and women. The probability value was multiplied by the utility value to determine the score for each drug and criterion. We investigated which test was most closely related to cerebro- and cardiovascular disorders (CCVD) in hemodialysis patients. Meiosis presents challenges to the DNA damage response (DDR) because it universally requires changes to chromosome structure that can affect DNA repair outcomes.

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Here, we identified human myogenic progenitor cells coexpressing Pax7, a marker of muscle satellite cells and bone-specific alkaline phosphatase, a marker of osteoblasts, in regenerating muscle. The worldwide re-emergence of secondary syphilis which happened in the last decade, has led to an increase in primary and secondary syphilis cases, along with the presentation of theophylline drug interaction with phenytoin atypical forms. The following questions should be considered when applying cfDNA screening in clinical practice: 1. Especially in the case of a finding of FBL by contrast enhancement, new diagnostic strategies should be employed to identify the underlying disorder rapidly and accurately. Here, we summarize the clinical, analysis-related and ethical problems regarding genetic counseling in multiple pregnancies. The Long Island tick rhabdovirus may represent a novel species within family Rhabdoviridae. The experimental results were also supported by molecular docking of compounds in the active site of 5-LOX. SSc patients were grouped into 22 patients with limited cutaneous SSc (lcSSc) and 27 patients with diffuse cutaneous SSc (dcSSc). For patch testing in children, the allergens should be applied for 24 hours and the readings should be performed at 48 and 72 hours. EECP and CAPE may hold promising prospects in treating inflammation-induced tumor.

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Thymic abnormalities and the chronicity of liver disease--report of 10 cases and follow-up study. Causal germline mutations in five autosomal genes (IFNGR1, IFNGR2, STAT1, IL12RB1, IL12B) and one X-linked (NEMO) gene have been described. Prediction of thermophilic protein with pseudo amino Acid composition: an approach from combined feature selection and reduction. Effects of rat platelet extracts and human platelet-derived growth factor on megakaryocytopoiesis in vitro. The lines varied by 700 fold in their sensitivity to the growth inhibiting effects of camptothecin and 30 fold in their response to etoposide. These findings indicate that computational simulation is an important tool for predicting the behavior and fate of carbon nano-particles in the aquatic environment. We evaluated the ability of PGE1 (1 to 100 microM) to protect endothelial cells (EC) from neutrophil injury induced by C5a or phorbol myristate acetate ( flagyl pills vs gel PMA).

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