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Anabrez (Anastrozole)
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Anabrez

Anabrez is an aromatase inhibitor approved by the U.S. Food and Drug Administration (FDA) to treat postmenopausal women diagnosed with advanced-stage or metastatic hormone-receptor-positive breast cancer.

Other names for this medication:
Altraz, Altrol, Anabrez, Anastrocare, Anastrozole, Anatero, Anazol, Armilon, Armotraz, Femistra, Femitraz, Qubol, Redest, Rimidex, Stazonex, Xenosoul

Similar Products:
Prometrium, Luvox, Colcrys, Eulexin, Tricor, Naprosyn, Feldene, Clozaril, Zudena, Artane, Medroxyprogesterone, Gastidom, Scaboz, Ceruvin, Formosone, Lyzop, Colcrys,

Also known as: Anastrozole

Description

Anabrez (anastrozole) lowers estrogen levels in postmenopausal women, which may slow the growth of certain types of breast tumors that need estrogen to grow in the body.

Anabrez is used to treat breast cancer in postmenopausal women.

Anabrez is often given to women whose cancer has progressed even after taking tamoxifen (Nolvadex, Soltamox).

Dosage

The following information describes Anabrez dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

Drug forms and strengths

Anabrez comes as 1-mg tablets that are taken by mouth.

Dosage for breast cancer

The usual dosage of Anabrez for breast cancer is one tablet taken once a day. It’s best to take your dose at the same time each day.

What if I miss a dose?

If you forget to take a dose of Anabrez, take the missed dose as soon as you remember. However, if it’s almost time for your next dose, just skip the missed dose and take your next dose as usual. Don’t take two doses together to make up for a missed dose.

To help make sure that you don’t miss a dose, try setting a reminder on your phone. A medication timer may be useful, too.

Will I need to use this drug long term?

Anabrez is meant to be used as a long-term treatment for breast cancer. If you and your doctor determine that Anabrez is safe and effective for you, you’ll likely take it long term.

The length of time that you’ll take this drug depends on the type of cancer you’re using it to treat. Below we describe the typical length of time that Anabrez is given. But to know for sure how long you should take Anabrez, talk with your doctor.

For advanced breast cancer

If you’re taking Anabrez to treat advanced breast cancer, you’ll usually take the drug for as long as your doctor feels this treatment is right for you. (With advanced breast cancer, the cancer has either spread to nearby areas or lymph nodes, called locally advanced breast cancer, or spread to other parts of your body, called metastatic breast cancer.)

For early breast cancer

If you’re taking Anabrez as adjuvant treatment of early breast cancer, you’ll usually take the drug for at least 5 years. Adjuvant treatment is used to lower the risk of your breast cancer coming back or spreading after it’s already been treated with surgery. (With early breast cancer, the cancer hasn’t spread out of either your breast or the lymph nodes in your armpit.)

It’s not currently known if Anabrez should be continued after these 5 years. And if so, it’s not known for how long after the first 5 years it should be taken.

Some studies found that breast cancer is less likely to come back if an aromatase inhibitor is taken for an additional 5 years after the first 5 years of adjuvant therapy. (Aromatase inhibitors are a class of medications.) With this approach to treatment, the drug would be taken for a total of 10 years. However, other studies didn’t show a benefit for extending the treatment beyond 5 the usual years.

In addition, one recent study found that taking Anabrez for a total of 10 years didn’t provide any more benefit than taking it for a total of 7 years.

How long you take Anabrez for early breast cancer will depend on how likely your breast cancer is to come back. It will also depend on your risk of side effects from treatment.

Overdose

If you overdose Generic Anabrez and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Anabrez are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Anabrez can interact with several other medications.

Different interactions can cause different effects. For instance, some interactions can interfere with how well a drug works. Other interactions can increase side effects or make them more severe.

Anabrez and other medications

Below are lists of medications that can interact with Anabrez. These lists do not contain all the drugs that may interact with Anabrez.

Before taking Anabrez, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Anabrez and tamoxifen

Like Anabrez, tamoxifen is a hormone therapy that’s used to treat breast cancer. But taking tamoxifen with Anabrez can lower the amount of Anabrez in your body. This can make Anabrez less effective for you.

Because of this interaction, you shouldn’t take tamoxifen with Anabrez. However, if recommended by your doctor, it’s fine to take Anabrez after you’ve finished taking tamoxifen.

Anabrez and drugs that contain estrogen

Taking Anabrez with drugs that contain estrogen could make Anabrez less effective for you. Because of this, you shouldn’t take these types of drugs while you’re using Anabrez.

Examples of drugs that contain estrogen include:

  • hormone replacement therapy (HRT)
  • vaginal estrogen products, such as creams and tablets
  • birth control medications, such as pills, patches, and vaginal rings
If you have questions about using medications that contain estrogen with Anabrez, talk with your doctor.

Anabrez and herbs and supplements

There aren’t any herbs or supplements that have been specifically reported to interact with Anabrez. However, you should still check with your doctor or pharmacist before using any of these products while taking Anabrez.

For example, it’s possible that supplements such as red clover or wild yam could make Anabrez less effective. (These supplements are used by some women to reduce menopausal symptoms, such as hot flashes.)

This interaction is possible because these supplements contain phytoestrogens, which are weak estrogen-like substances found in certain plants. There isn’t enough information available to say for sure whether taking phytoestrogens can affect your breast cancer treatment or not.

Be sure to talk with your doctor before taking any herbs or supplements with Anabrez.

Anabrez and foods

There aren’t any foods that are known to interact with Anabrez. Talk with your doctor to find out if there are any foods you should avoid during Anabrez treatment.

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No changes in corneal neurotrophin or nerve pathfinding gene expressions accompany corneal transition to nerve growth cone permissiveness. Pitchers with 3 or more years in a stretch program (group 1) had greater internal rotation (74.3 degrees vs 54.3 degrees ) and greater total range of motion (217.0 degrees vs 194.2 degrees ) in dominant shoulders than did pitchers with less than 3 years (group 2). During the surgical exploration, rupture of the posterior cruciate ligament associated with thrombosed popliteal artery have been found. Impaired arterial elasticity is considered to be a marker of vascular (endothelial) dysfunction and to be involved in the atherosclerotic process. At the same time, some important differences are observed between the sizes of the binding pockets as well as some of the residues involved in binding. Computed tomography revealed a relatively well-defined, high-density mass near the lacrimal gland. The saccades tricor medication side effects in GD may differ markedly from normal saccades, and the two can be reliably distinguished.

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Using the nitric oxide synthase inhibitor, L-NG-monomethylarginine (L-NMMA), we examined the contribution of endogenous nitric oxide to substance P-induced t-PA release in vivo in man. The current study examined whether (a) Al leads to impairment of spatial alternation after extended practice, (b) Al enhances performance of an operant task that emphasizes motor learning and ability (differential reinforcement of high rates, DRH), and (c) Al enhances food motivation as reflected in progressive ratio (PR) performance. A peptide spanning amino acids 91-108 was recognized in 6 out of 9 vaccinated patients and in 8 out of 9 nonvaccinated, sero-positive patients, being the most dominant antigenic epitope in NY-ESO-1 for antibody recognition in cancer patients. Self-relevance was manipulated in two ways: by testing currently married compared with previously married individuals and by assessing self-relevance ratings individually for each word. Synergism of Nanomaterials with Physical Stimuli for Biology and Medicine. A number of studies using cross-sectional data have demonstrated that the availability of alcohol, measured by the number and types of alcohol outlets, is directly related to numerous measures associated with drinking and driving. This is the first report of an outbreak of histoplasmosis, in which two cases were reported and the fungus was isolated at the focus of the epidemic, in the state of Santa Catarina.

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Heterogeneity in vascular density was observed in different lesions within the same patient. There is no indication of the existence of distinct morphological classes of RGCs. Endoscopic management of oesophageal food bolus obstruction: flexibility is the way forward. Microarray data revealed that the smd3-b mutant had altered expression of genes related to the above phenotypes, indirectly suggesting that changed splicing of these genes may cause the observed phenotypes. Generation of Esr1-knockout rats using zinc finger nuclease-mediated genome editing. The relationship between whole-cell redox potential, cytochrome composition in free-living culture and symbiotic activity of Sinorhizobium meliloti was studied. Orthopedic oncologists often encounter patients with minor bony lesions that are difficult to access surgically and therefore require large exposures out of proportion to the severity of disease that confer significant patient morbidity.

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BTFC and LTFC provided a significant reduction in IOP from baseline without changing any anterior ocular parameters. There were no differences between the two raters for any of the three measurements of foot posture. Long-term treatment with clopidogrel deserves further assessment. Here, spectra acquisitions by microchip-based nanoflow-direct-infusion QTOF mass spectrometry, a simple and high throughput technique, is tested for its informative power. Recent observations show that some long-duration GRBs are different.

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