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Amitriptyline

Amitriptyline is used to treat mental/mood problems such as depression. Amitriptyline may help improve mood and feelings of well-being, relieve anxiety and tension, help you sleep better, and increase your energy level. Amitriptyline belongs to a class of medications called tricyclic antidepressants. It works by affecting the balance of certain natural chemicals in the brain.

Other names for this medication:
Amicure, Amidez, Amimax, Amitin, Amitriptyline, Amitryptyline, Amixide, Amize, Amizep, Amoten, Amrea, Amtipax, Amypres, Arpidox, Axtrip, Chlotrip, Cotrip, Eliwel, Estiline, Gentrip, Libral, Librodep, Limbival, Mitryp, Nextrip, Psycomer, Raitrip, Ronet, Sarotena, Tadamit, Teedep, Tridep, Triplent, Tryline, Tryptomec

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Description

Amitriptyline target is the treatment of depression. Amitriptyline is acting by increasing the amounts of certain natural substances in the brain that are needed to maintain mental balance. It is tricyclic antidepressant. Generic name of Amitriptyline is Amitriptyline. Amitriptyline is also known as Amitriptyline, Amitryptyline, Amidon, Amitryn, Tryptanol, Endep, Elatrol, Tryptizol, Trepiline, Laroxyl, Saroten, Triptyl, Amitrip. Brand names of Amitriptyline are Amitriptyline, Endep, Vanatrip.

Dosage

Usual Adult Dose for Depression:

OUTPATIENTS: -Initial dose: 75 mg orally per day in divided doses; this may be increased to 150 mg/day (if needed) -Maintenance dose: 40 to 100 mg orally per day -Maximum dose: 150 mg/day Alternate outpatient treatment regimen: 50 to 100 mg orally as a single dose at bedtime; this may be increased by 25 or 50 mg as needed at bedtime to a total of 150 mg/day INPATIENTS: -Initial dose: 100 mg orally per day -Maintenance dose: 40 to 100 mg orally as a single dose at bedtime -Maximum dose: 300 mg/day Comments: -Dose increases should preferably be made in the late afternoon or at bedtime due to the sedative effect. -The full therapeutic effect may take as long as 30 days to develop. -Maintenance doses should be reduced to the lowest amount that will maintain relief of symptoms when satisfactory improvement has been obtained. -Maintenance therapy should be continued for 3 months or longer to lessen the possibility of relapse. Use: Relief of symptoms of depression

Usual Geriatric Dose for Depression:

10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. -Elderly patients should be monitored carefully and serum levels obtained as clinically appropriate. -Dose adjustments should be made according to clinical response. Use: Relief of symptoms of depression

Usual Pediatric Dose for Depression:

12 years or older: 10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. -Dose adjustments should be made according to clinical response. Use: Relief of symptoms of depression

Detailed Amitriptyline dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of amitriptyline can be fatal.

Overdose symptoms may include irregular heart rhythm, feeling like you might pass out, seizures, or coma.

Storage

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Amitriptyline are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Amitriptyline if you are allergic to amitriptyline, or:

if you have recently had a heart attack.

Do not use Amitriptyline if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone.

To make sure Amitriptyline is safe for you, tell your doctor if you have ever had:

bipolar disorder (manic-depression) or schizophrenia; mental illness or psychosis; liver disease; heart disease; a heart attack, stroke, or seizures; diabetes (amitriptyline may raise or lower blood sugar); glaucoma; or problems with urination.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Tell your doctor if you are pregnant or breastfeeding.

Amitriptyline is not approved for use by anyone younger than 12 years old.

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To assess the efficacy of various therapeutic principles of TCM in treating patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). It occurred in a young woman with a history of recent abortion, as a painful mass confused with an abscess. Hepatic hydatid disease is still a commonly seen problem in endemic areas as well as in our country. Our results identify stathmin as a main target of the Raf/MEK/ERK kinase cascade in vivo and strongly suggest that ERK-mediated stathmin phosphorylation plays an important role for the microtubule reorganization induced by acute activation of Raf-1. Melancholic MDE was more severe than atypical MDE although the two groups shared many characteristics.

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Agranulocytosis in memory of Edgar Reye (30 May 1882-11 December 1945). Since the turn of the nineteenth century, when their existence was first recognized, viruses have attracted considerable interest as possible agents of tumor destruction. A highly efficient in situ N-acetylation approach for solid phase synthesis. No changes in serum LH, FSH and inhibin B levels were observed throughout the experimental period. These findings indicate that spatially limited expression of a large number of genes is part of flower development and that its extent differs significantly between the reproductive organs and the organs of the perianth. Bulimia nervosa, restrained, and unrestrained eaters: a comparison of non-binge eating behavior. Thirteen of them were already established on long-term O2 therapy (LTOT), while 11 were not. This happens through a re-entry orifice at the level of the descending thoracic aorta and may seriously compromise the cerebral and coronary circulation.

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However, our results suggest that controlled studies of HDT plus ABMT should be proposed for higher risk patients. To describe the epidemiology of adult patients hospitalised with influenza or pneumonia during a pandemic season in a sentinel network in Australia. In this review, we discuss the current knowledge of chemokine:receptor structure and function, and its contribution to drug discovery. Questing behavior of Ixodes pacificus (Acari: Ixodidae) in relation to meteorological and seasonal factors. Effects of X-ray on the metacestodes of Echinococcus granulosus in vitro. Treatment of hyperphosphatemia in hemodialysis patients: The Calcium Acetate Renagel Evaluation (CARE Study). Therefore, new allopolyploids must establish a compatible relationship between alien cytoplasm and nuclei and between two divergent genomes, leading to rapid changes in genome structure, gene expression, and developmental traits such as fertility, inbreeding, apomixis, flowering time, and hybrid vigor. Low serum calcium, elevated serum phosphate, normal renal functions, raised tubular maximum of phosphate and high serum parathormone were suggestive of PHP.

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Imaging out-of-plane polarized emission patterns on gap mode SERS substrates: from high molecular coverage to the single molecule regime. Ultrastructure and pigment composition of the photosynthetic apparatus of the green alga Ulvaria obscura during the polar day and polar night. A quantitative descriptive study of the prevalence of carriage (colonisation) of haemolytic streptococci groups A, B, C and G in pregnancy. Insulin resistance has been implicated in the pathogenesis of both nonalcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome (PCOS). From Integrated Pest Management point of view, TRP channels could be a possible new target site of pest control agents as well as the primary or secondary target site for known insecticides. We report on an infant with multiple congenital anomalies and a novel 2.6 Mb interstitial deletion within 9q21.32q21.33 detected by aCGH. The liver fluke Platynosomum fastosum can you take 80 mg of protonix daily was identified upon necropsy of three ex-captive orangutans (Pongo pygmaeus) which had been part of a rehabilitation program for reintroduction to the wild.

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Formation of LC3-II complexes was inhibited by ethanol in caspase-3 deficient MCF-7 cells. In this study, we sought to confirm the association between known variants and breast cancer in Korean women and further evaluate the associations of individual single nucleotide polymorphisms (SNP) with different intrinsic subtypes of breast cancer. Sex-related differences in the clinical presentation and outcomes of stroke patients are issues that have attracted increased interest from the scientific community. Gelation time and hydrogel stability were gravely affected by the pH of the surrounding medium. Data are lacking for surgical outcomes by the tumor site of origin. We sought to assess the effect of adolescent-onset SLE on the clinical course of a large multi-ethnic cohort. ATG16L1 is a CD susceptibility gene without epistatic interaction with other CD susceptibility genes and is not upregulated in intestinal inflammation. An antibody with a size of about 10 nm has the same capacity for passive targeting as some DDS carriers, depending on the EPR effect. 30 plants of each of 50 accessions plus 6 regeneration populations included in the study were characterised with AFLPs, using scores for 103 polymorphic bands.

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Herpes simplex ocular infection is the leading cause of infectious corneal blindness in the United States and presents a frequent challenge to ophthalmologists. Patients listed for coronary artery bypass surgery with at least one poorly controlled risk factor were randomised to standard care or the intervention which provided lifestyle counselling and preparation for surgery at monthly intervals. A total of 10 nursing-related strategies were identified from current evidence-based guidelines for preventing infections associated with use of central venous catheters. Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4. The availability of recombinant human IGF-I (rhIGF-I) has led to new treatments for GH-resistant Laron dwarfism and certain diseases associated with severe insulin resistance. The thymidine reaches the far sides of the quiescent centre from both directions. Enhanced visualization of the intracranial lesion enables the neurosurgeon to choose a safe surgical trajectory that avoids critical structures, to maximize the extent of the tumor resection, and to exclude an intraoperative hemorrhage. Epigastric antinociception by cervical dorsal column lesions in rats. The rats were allocated into high and low baseline groups depending on their baseline PPI observed after saline treatment. The clinical and functional outcome of this hybrid fixation technique is rewarding.

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In this study, a drug delivery system targeting fibronectins (FNs), a prevailing component in the ECM of many solid tumors, was constructed for glioma therapy based on the interaction between the abundant FNs in glioma tissues and the FNs-targeting moiety CLT1 peptide. A 75-year-old man had noticed increasing growth of hair over his entire body 4 months before he was admitted to our hospital because of bloody stools. Four electronic databases were searched for controlled clinical trials of antifungal herbal medicines. Our findings support the postulated affective pathway from NSS to positive symptoms via negative affect. The warning signal significantly reduced EMG-RT of both movements and the reduction of EMG-RT was larger in supination than flexion. Failure to recognise this as being due to choriocarcinoma led to a delay in diagnosis and effective treatment which, given earlier, may have proved lifesaving.

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