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Alzokam (Alprazolam)
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Alzokam

Alzokam is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder. It's also used in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Alzokam, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Alzokam is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Alfix, Alprawin, Alprocalm, Alpron, Alzac, Alzoact, Alzolite, Anilam, Anxigo, Ateez, Axizox, Cardilax, Endep, Endolam, Enxolam, Exprex, Faxtin, Fledore, Fluprax, Fluxin, Jolistar, Luzarn, Nokzok, Nucalm, Pacyl, Poize, Pronext, Resta, Restyl, Riolam, Serxanti, Sozox, Tancalm, Tensfree, Tenzorid, Zodia

Similar Products:
Aricept, Glucotrol, Lasix, Mobic, Precose, Hytrin, Colospa, Asacol, Rebetol, Benemid, Betaderm, Meramyl, Zumatic, Rovamet, Enacecor, Istopril,

Also known as: Alprazolam

Description

Alprazolam is used to relieve symptoms of anxiety, including anxiety caused by depression. It is also used to treat panic disorder in some patients.

Alprazolam is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain alprazolam. It may not be specific to Alzokam XR. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is used for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the extended-release tablet or tablet whole with a full glass of water. Do not break, crush, or chew it.

If you are using the orally disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not remove the tablets from the bottle until you are ready to take it. Place the tablet immediately on the top of your tongue. It should melt quickly and be swallowed with saliva.

If you are using the oral liquid, measure the dose with a marked measuring spoon, oral syringe, or medicine cup.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For anxiety: For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.25 to 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 4 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For panic disorder: For oral dosage form (extended-release tablets): Adults—At first, 0.5 to 1 milligram (mg) taken in the morning once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.5 mg taken in the morning once a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor.

Overdose

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of Alzokam XR can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, fainting, and coma.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details.

Side effects

The most common side effects associated with Alzokam are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not use Alzokam XR if you have:

narrow-angle glaucoma; if you are also taking itraconazole (Sporanox) or ketoconazole (Nizoral); or if you are allergic to alprazolam or to other benzodiazepines, such as chlordiazepoxide (Librium), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), or oxazepam (Serax).

Before taking Alzokam XR, tell your doctor if you are allergic to any drugs, or if you have:

asthma, emphysema, bronchitis, chronic obstructive pulmonary disorder (COPD), or other breathing problems; glaucoma; kidney or liver disease (especially alcoholic liver disease); a history of depression or suicidal thoughts or behavior; or a history of drug or alcohol addiction.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.

It is dangerous to try and purchase Alzokam XR on the Internet or from vendors outside of the United States. Medications distributed from Internet sales may contain dangerous ingredients, or may not be distributed by a licensed pharmacy. Samples of alprazolam purchased on the Internet have been found to contain haloperidol (Haldol), a potent antipsychotic drug with dangerous side effects. For more information, contact the U.S. Food and Drug Administration (FDA) or visit www.fda.gov/buyonlineguide

FDA pregnancy category D. Alzokam XR can cause birth defects in an unborn baby. Do not use Alzokam XR without your doctor's consent if you are pregnant. Tell your doctor if you become pregnant during treatment. Use an effective form of birth control while you are using this medication. Alprazolam can pass into breast milk and may harm a nursing baby. Do not use Alzokam XR without telling your doctor if you are breast-feeding a baby.

The sedative effects of Alzokam XR may last longer in older adults. Accidental falls are common in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury while you are taking Alzokam XR. Do not give this medication to anyone under 18 years old.

Alzokam XR pregnancy and breastfeeding warnings (more detail)

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Thirty-four populations from Siberian and other circum-Pacific regions were compared in terms of facial flatness measurements of the cranium. Ivermectin is a newer oral drug for the treatment of ectoparasites, which has been used with great success in the treatment of onchocercosis and other endoparasites. Better uptake of design recommendations through enhanced collaboration between research teams is likely to produce better mortality statistics from an increasing number of verbal autopsy studies. Outcome of early endoscopic biliary drainage in the management of bile leaks after hepatic resection. Dyschromia (leukomelanodermia) resulting from local administration of p-benzyloxyphenol. A mutant cholera toxin B subunit that binds GM1- ganglioside but lacks immunomodulatory or toxic activity. Most algorithms require a significant amount of user interaction and use a voxel grid to compute discrete and often coarse approximations of this representation of the data. Application of complete denture implant rehabilitation in irradiated mandible. Curettage was performed if the gestational sac remained on day 8 or as necessary during at least 30 days of follow-up.

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Hypoxia/reoxygenation has been incriminated as a major factor in the pathogenesis of ischemia/reperfusion injury in various ischemic diseases such as rheumatoid arthritis (RA). The results over a follow-up period ranging from 6 to 40 months showed 23.8 per cent recurrence in group 1 patients treated with BCG (21 patients), 46.7 per cent recurrence in group 2 treated with anti-cancer agents (45 patients) and 52.3 per cent recurrence in the group 3 (127 patients) which were not received any intravesical drugs. Some Implications Afforded by Mortality and Morbidity Statistics. The viability and postpartum development of the offspring were normal, as judged by gross macroscopic examination. Many shotgun proteomics techniques randomly sample thousands of peptides in a qualitative and quantitative manner but overlook the vast majority of protein modifications that are often crucial for proper protein structure and function.

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IFN-alpha-induced apoptosis is directed by an extrinsic death receptor signaling pathway, amplified by an intrinsic mitochondrial pathway. Expansion of the brain is coupled with calvarial growth through a series of tissue interactions within the cranial suture complex. Hospital construction: arrangements with architects and contractors. The repeat region of Pur cDNA is homologous to multiple mRNA species in each of several human cell lines and tissues. Transforming growth factor alpha and epidermal growth factor in protection and healing of gastric mucosal injury. Vacuous chewing movements (VCM) in rats, a widely accepted animal model of tardive dyskinesia was employed in the present study.

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Longitudinal study of plasma lipoproteins and hormones during pregnancy in normal and diabetic women. Picornavirus genome replication: assembly and organization of the VPg uridylylation ribonucleoprotein (initiation) complex. Changes in CpG islands promoter methylation patterns during ductal breast carcinoma progression. Additionally, for both receptors, the inclusion of hormone during the recovery period leads to a retardation of nuclear mobility. Self-assembled growth of nanocomposites consisting of TiO(2) nanopillars and Pb(Zr(0.52)Ti(0.48))O(3) thin films. Although the MC flap was a proximal part of the latissimus dorsi muscle, which was dissected along the posterolateral incision of the first operation, it could be successfully transplanted to cover the BPFs in the open-window. These heterotopias are frequently observed as microscopic abnormalities in the brains of individuals with central nervous system (CNS) malformations and epilepsy. Particular emphasis is placed on factors influencing the likelihood of pathogens making their way from infected livestock and humans to the soil surface, and therefore the chances of them being available for transport by overland flow. Amino acids in the blood and urine of normal and arthritic subjects before and after a glycine load given with and without adrenocorticotropin.

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In addition to evaluating novel combinations, alternative schedules to improve toxicity profiles are subjects of clinical trials. Furthermore, the hazard ratio for patients negative for OLIG1 protein was significantly higher than the one for those patients expressing the protein, even at low levels. An experimental single-step bonding system, RZ-II, has been developed as a resin coating material for crown preparation. Dose response curves were obtained for acetylcholine, histamine and barium chloride in the presence of ketamine. Generally, they contain a similar extracellular conserved motif of four cysteines, and amino acid sequence--WSXWS (interacting directly with ligand) but possess no catalytic domens in the intrinsic tail of the chains. Docosahexaenoic acid modulates the expression of T-bet and GATA-3 transcription factors, independently of PPARalpha, through suppression of MAP kinase activation.

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Molecular characterizations have identified ALK fusions involving tropomyosin-3 and -4 (TPM-3 and -4), the clathrin heavy chain (CLTC), and the cysteinyl-tRNA synthetase (CARS) genes as fusion partners. Extensive data document the adverse impact chronic pain can have on physical and psychosocial functioning. The ester substrate is the only generic drug name of zantac one that efficiently competes with and hinders the hydrolysis of the aminolysis product. Glutathione S-transferase is a novel target for mood stabilizing drugs in primary cultured neurons. However, strong training induced a significant increase in H3 acetylation 1-h post-training, returning to basal levels afterward. A new lanostane-type triterpene glycoside, impatienside A (1), was isolated from the sea cucumber Holothuria impatiens, together with a structurally related, known compound, bivittoside D (2). The effect of LVP on DC polarization was reversed by IFNalpha, providing an additional rationale for the interferon therapy of chronically-infected patients. Treatment of epileptic negative myoclonus relies on the drugs that are effective in focal epilepsies, but it is usually pharmacoresistant. We describe a novel accurate method to measure energy transfer between two beams coupling in photorefractive materials.

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The rapidly increasing number of monoclonal antibodies approved for immunotherapy has paved the way to an even greater demand for antibody molecules. Sensitivity of guinea pig aorta to norepinphrine, phenylephrine, methoxamine and potassium: effect of reserpine, 6-hydroxydopamine and cocaine. Our results indicated that the ds-DNA arrays can be further biochemically modified and made accessible for interactions between DNAs and proteins in complex multi-step gene-regulation processes. Acute liver failure as the initial manifestation of acute leukaemia. All patients diagnosed with MDR-TB in Galicia, Spain, between 1998 and 2004 were included in the study. The kinetics of glycol destruction by a Pseudomonas putida BS-2 strain. Operative time, transfusion rate, time to oral intake and complications were also similar. zyprexa dosing Diffraction-limited soft-x-ray projection imaging using a laser plasma source. The relationship between serum copper and ceruloplasmin in routine clinical practice. Hopefully, this brief coverage of congenital ocular anomalies will provide useful information and assist in appropriate communication to concerned parties.

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Canine models of allogenic living donor liver transplantation was established in 14 beagle dogs by non-venous by-pass method, and in 7 of the recipients, autologous MSCs labeled by BrdU was infused into the portal vein, with the other 7 dogs as the control. One of the key problems of medical genetics today is to identify nsSNPs that underlie disease-related phenotypes in humans. vermiformis was inhibited within 3 days of administering the challenge inoculum. Medical consultation is imperative for these patients before administering a fluid challenge during general anesthesia. With the use of a phosphorothioated antisense oligodeoxynucleotide (ODN) to p21, which has previously been shown to decrease specifically and effectively p21 protein levels in a variety of cell types, it is shown that attenuation of p21 in MC leads to a dose-dependent reduction of hypertrophy in the milieu of hyperglycemic culture media. Effect of simulated postprandial hyperglycemia on coronary blood flow in cardiac transplant recipients.

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