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Alpranex (Alprazolam)

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Alpranex is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder. It's also used in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Alpranex, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Alpranex is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Acalm, Aldep, Aleez, Alfix, Alpam, Alprasan, Alprastan, Alprazan, Alpron, Alsert, Alzex, Alzocum, Alzonex, Anxicalm, Anxigon, Anxilam, Anxyl, Aryalam, Azicalm, Coolam, Depflu, Depser, Dizeral, Endep, Endolam, Esteem, Eurolam, Flumusa, Golprax, Omelam, Onapract, Prazolam, Propnix, Rescalm, Restam, Restyl, Romipraz, Setlan, Somnarest, Tagat, Zedel, Zepro, Ziety, Zolam

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Also known as: Alprazolam


Alpranex (alprazolam) is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). It is thought that alprazolam works by enhancing the activity of certain neurotransmitters in the brain.

Alpranex is used to treat anxiety disorders and anxiety caused by depression.

Alpranex is also used to treat panic disorders with or without a fear of places and situations that might cause panic, helplessness, or embarrassment (agoraphobia).

It is dangerous to purchase Alpranex on the Internet or outside the United States. The sale and distribution of medicines outside the U.S. does not comply with safe-use regulations of the Food and Drug Administration (FDA). These medications may contain dangerous ingredients, or may not be distributed by a licensed pharmacy.


This section provides information on the proper use of a number of products that contain alprazolam. It may not be specific to Alpranex. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is used for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the extended-release tablet or tablet whole with a full glass of water. Do not break, crush, or chew it.

If you are using the orally disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not remove the tablets from the bottle until you are ready to take it. Place the tablet immediately on the top of your tongue. It should melt quickly and be swallowed with saliva.

If you are using the oral liquid, measure the dose with a marked measuring spoon, oral syringe, or medicine cup.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For anxiety: For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.25 to 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 4 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For panic disorder: For oral dosage form (extended-release tablets): Adults—At first, 0.5 to 1 milligram (mg) taken in the morning once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.5 mg taken in the morning once a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention if you think you have used too much of this medicine. An overdose of Alpranex XR can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, fainting, and coma.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is very important to protect the orally disintegrating tablets from moisture. Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine.

Detailed Alpranex XR dosage information

Side effects

The most common side effects associated with Alpranex are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not use Alpranex if you are pregnant. It could harm the unborn baby.

Do not use this medication if you are allergic to Alpranex or to other benzodiazepines, such as chlordiazepoxide (Librium), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), or oxazepam (Serax).

Before you take Alpranex, tell your doctor if you have asthma or other breathing problems, glaucoma, kidney or liver disease, a history of alcoholism, or a history of depression, suicidal thoughts, or addiction to drugs or alcohol.

Do not drink alcohol while taking Alpranex. This medication can increase the effects of alcohol.

Alpranex may be habit-forming and should be used only by the person for whom it was prescribed. Keep the medication in a secure place where others cannot get to it.

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Optimisation of cellobiose dehydrogenase production by the fungus Sclerotium (Athelia) rolfsii. We have elicited similar patterns in several other patients, who had marginally low serum magnesium and who also exhibited weakness, anxiety, and psychosomatic disorders. Further work is required to determine the antigens recognized by many of the other mAb. The aim of the present study was to investigate the opioid-sparing and analgesic effects of gabapentin administered during the first 24 h after abdominal hysterectomy. Evidence of horizontal gene transfer between amoeba and bacteria. The synthesis of GAGs/PGs by the MG-63 cells in the presence of genistein was dependent on their type and localization, suggesting that a more complex mechanism regulates the PG synthesis.

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Early diagnosis, meticulous antenatal care, early hospitalization, frequent evaluation of fetal well being, delivery by cesarean section and on site availability of trained neonatologists and a highly functional intensive care unit are essential for better outcome. In clinical trials of moderate-to-severe asthma, omalizumab allowed a reduction in inhaled corticosteroid dosage while improving peak flows and reducing exacerbations, particularly in patients at high-risk of serious asthma-related morbidity and improved quality of life scores. Spatial variations in community structure of the consortium relative to the PCE source zone were observed. The results supported the major premise of the theoretical model that risk factors are more important the more proximal they are in a theoretical chain of events leading to mortality. Then, the 15-kDa protein was purified by reverse-phase high performance liquid chromatography and the protein was demonstrated to induce immediate positive skin reactions in patients with bronchial asthma. Risk factors for such a reaction and suggested alternative are reviewed. Conversely, Western blotting with the amastigote specific monoclonal antibody (T16) showed that this antigen is more highly expressed in AxA than promastigotes. Nosocomial chickenpox (varicella) in health care staff at an infectious diseases unit. Detailed analysis of the SRC promoters suggested that both core and proximal promoter elements were responsible for HDI-mediated repression.

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To research the maturation regulation of dendritic cells (DCs) pulsed with hepatocellular carcinoma (HCC) cell soluble antigens. Increased expression of ICAM-1, LFA-1 and Mac-1 preceded leukocyte infiltration. Currently, radical cholecystectomy in stages II and III has become another important prognostic factor. Flow cytometry of fluorescein isothiocyanate-labelled ghosts exposed to 37 degrees C demonstrated the two peaks corresponding to ghosts with normal spectrin content and decreased one. Multiplex PCR assay for identification of Corynebacterium pseudotuberculosis from pure cultures and for rapid detection of this pathogen in clinical samples. A method is proposed for quantitative estimation of synchronization between these oscillating processes based on calculation of relative time of phase synchronization of oscillations.

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A growth defect was observed in the cpmk1-null mutant under hyperosmotic conditions, indicating that cpmk1 functionally belongs to a hog1 subfamily. Prevalence and correlates of anxiety symptoms in well-functioning older adults: findings from the health aging and body composition study. Despite the use of intracardiac echocardiography to help direct radiofrequency (RF) application to the anatomic target of the superolateral crista terminalis (CT), multiple RF lesions often are required. The only therapeutic option is a bone marrow transplantation, which we conferred upon our patient. Higher levels of amniotic fluid neutrophil elastase are associated with a shorter interval from admission to delivery in women with subclinical chorioamnionitis. In 3 cases additionally appeared: waxy pallor of optic disc, vascular narrowing, reflexless hypoplastic macula, pigmentless periphery, acquired blue-yellow blindness, concentric limitation of the visual field, reduced darkadaptation, abolished electroretinogram and myopic astigmatism. The aim of the present study was to investigate the efficacy of combined administration of with eglonil and ovestin in low doses for the pharmacocorrection of depressive disorders in women after total ovariectomy.

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The realisation of efficient genosensors relies crucially on the surface chemistry strategy selected for the immobilisation of DNA probes. Self-hypnosis and computer monitoring in the management of obesity. Depending on the preoperative imaging and working diagnosis, endoscopic biopsy or endoscopic resection/debulking, along with concomitant treatment of hydrocephalus via third ventriculostomy or fenestration of the septum pellucidum prilosec 40 mg over the counter and ventriculo-peritoneal shunting, were done. This study aimed at the synthesis of novel structurally promising steroidal heterocycles and to elucidate the potential role of these compounds as antibacterial agents. These expressions show explicitly how the accuracy of the method varies with the normalized frequency, the mode orders, the dimensions of the waveguide, and the relative refractive indices of the core and the surrounding media.

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Adoptive transfer of Pfp(-/-)FasL(-/-) chNKG2D T cells had reduced in vivo efficacy, indicating that chNKG2D T cells used both mechanisms to attack RMA/Rae1 cells. The aim of this study was to examine the expression and function of B7-H2 in human airway smooth muscle (ASM) cells and compare them with those of CD40 or OX40 ligand (OX40L). Bilateral renal angiomyolipoma associated with bilateral renal vein and inferior vena caval thrombi. We used the Consumer Price Index to determine the effects of inflation. This inhibition was specific to the tetO-modified allele, did not affect neighboring genes, and was reversible by administration of doxycycline to the pregnant female. Kinetics and bioenergetics of Spirulina platensis cultivation by fed-batch addition of urea as nitrogen source.

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Aberrant high-frequency desynchronization of cerebellar cortices in early-onset psychosis. A quadrature Mach-Zehnder interferometer based on a 3 x 3 fiber coupler is presented. Analysis of isometric contraction of isolated striated muscle in various types of fatigue tests. In severely burned pediatric patients, enteral nutrition supplied predominantly as carbohydrate rather than fat improves the net balance of skeletal muscle protein across the leg. Here we show that, following its synthesis on mitochondrial ribosomes, subunit 6 of the ATPase (Atp6p) can be cross-linked to Atp10p. Spinal cord injury (SCI) remains a major challenge to neurological research. Described are biochemical and mouse genetics experiments demonstrating that membrane-associated Nephrin is tyrosine-phosphorylated by the Src family kinase Fyn.

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We report our 8-year experience with corpus callosotomy using a frameless stereotactic image-guided system (ISG Viewing Wand). Suspension of the algae treated with (C6H5)3SnCl at concentrations of 1.0 and 4.0 micromol dm(-3) for 22 h revealed a decrease in most physiological parameters studied, particularly in decasecond component of delayed chlorophyll luminescence, photosynthetic electron transport rate and diluted oxygen concentration, which implies an inhibition of photosynthetic electron transport as well as oxygen evolving system. During hypo-osmotic shock, it responses to membrane tension through large conformational changes, that lead to an open state of the pore. Receptor binding characteristics of the endocrine disruptor bisphenol A for the human nuclear estrogen-related receptor gamma. The ICF is a useful tool to examine and compare contents of instruments in stroke rehabilitation. Is fasting blood glucose a reliable parameter for screening for diabetes in hypertension?. We have established the novel cell line NK-YS, which preserves the original characteristics of EBV-associated nasal angiocentric T/NK cell lymphoma. Incubation of VSV(HIV-1(IIIB)) and VSV(HIV-1(Ba-L)) viruses with appropriate HIV-1 neutralizing sera before infection strongly inhibited entry of pseudotyped VSV into syncytiotrophoblast cells. How physician gender shapes the communication and evaluation of medical care. Seven obese hyperinsulinemic subjects were administered 400 mg troglitazone daily for 4 weeks.

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Development of predictive quantitative retention-activity relationship models of HMG-CoA reductase inhibitors by biopartitioning micellar chromatography. In P.tetraurelia the repeat was identified in the subtelomeric region of four randomly selected telomere clones, as well as downstream of the A type variable surface protein gene. Insulin therapy to biaxin antibiotic and alcohol rapidly induce preischemic normoglycemia improved outcome from forebrain ischemia in the acutely diabetic rats. Electro-optic coefficient measurements: correction of electric-field inhomogeneities in the transverse configuration. Gene-encoded antimicrobial peptides that are believed to kill micro-organisms via pore formation have been found in the surface cells and secretions of plants and insects, and in the skin of frogs. However, the serum total cholesterol after 4 wk of egg consumption was significantly higher than the control values. There were no consistent chromosomal rearrangements associated with apparently translocation negative ARMS cases.

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