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Alpostin (Alprostadil)

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Alpostin injection and suppositories are used to treat certain types of erectile dysfunction (impotence; inability to get or keep an erection) in men. Alpostin is in a class of medications called vasodilators. It works by relaxing the muscles and blood vessels in the penis to keep enough blood in the penis so that an erection can occur.

Other names for this medication:
Alpostin, Caverject, Edex, Muse, Prostin, Vitaros

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Also known as: Alprostadil


Alpostin urethral suppository is used to treat men who have erectile dysfunction (also called sexual impotence). It belongs to a group of medicines called vasodilators that can increase blood flow by expanding blood vessels. This medicine causes an erection because it increases the blood flow to the penis.

Alpostin should not be used as a sexual aid by men who do not have erectile dysfunction. If the medicine is not used properly, permanent damage to the penis and loss of the ability to have erections could result.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Suppository


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For urethral dosage form (suppositories):
    • For erectile dysfunction:
      • Adults—One suppository inserted into the urethra once a day, 10 to 30 minutes before sexual intercourse. Do not use more than 2 suppositories each day.
      • Children—Use is not recommended.


If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: fainting, painful/prolonged erection.


Store at the room temperature 25°C (77°F)or below. The medication should be used within 24 hours after opening. Do not freeze it. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

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The most common side effects associated with Alpostin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Before using Alpostin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: penis conditions (e. g. , angulation, fibrosis/scarring, Peyronie's disease), blood system cancers (e. g. , leukemia, multiple myeloma), sickle cell anemia. Use of this drug does not protect against sexually transmitted diseases (e. g. , HIV, hepatitis B, gonorrhea, syphilis). To decrease your risk of infection, always use an effective barrier method such as a latex or polyurethane condom during all sexual activity. Consult your doctor or pharmacist for more details.

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