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Allerdain (Desloratadine)
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Allerdain

Allerdain and its metabolic derivative desloratadine are second generation antihistamines that are used for the treatment of allergic rhinitis, angioedema and chronic urticaria. Allerdain and desloratadine have been linked to rare, isolated instances of clinically apparent acute liver injury.

Other names for this medication:
Alerdain, Allerdain, Allerde, Allerede, Allergesic, Biomon, Dazit, Delorta, Desent, Deslor, Desloranid, Desloratadine, Desloriv, Desnova, Dilora, Lorday, Loreta, Nelora, Neoloridin, Nucope, Otrivin, Reditabs, Rodera, Tastylora, Veromon

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Abhigra, Aurogra, Valium, Sustiva, Propecia, Vantin, Danocrine, Glyburide, Onzem, Waklert, Revatio, Diamin, Ditensor, Anxiset, Durogest,

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Also known as: Desloratadine

Description

Cough/cold combinations are used mainly to relieve the cough due to colds, influenza, or hay fever. They are not to be used for the chronic cough that occurs with smoking, asthma, or emphysema or when there is an unusually large amount of mucus or phlegm (pronounced flem) with the cough.

Cough/cold combination products contain more than one ingredient. For example, some products may contain an antihistamine, a decongestant, and an analgesic, in addition to a medicine for coughing. If you are treating yourself, it is important to select a product that is best for your symptoms. Also, in general, it is best to buy a product that includes only those medicines you really need. If you have questions about which product to buy, check with your pharmacist.

Since different products contain ingredients that will have different precautions and side effects, it is important that you know the ingredients of the medicine you are taking. The different kinds of ingredients that may be found in cough/cold combinations include:

Antihistamines—Antihistamines are used to relieve or prevent the symptoms of hay fever and other types of allergy. They also help relieve some symptoms of the common cold, such as sneezing and runny nose. They work by preventing the effects of a substance called histamine, which is produced by the body. Some examples of antihistamines contained in these combinations are:

Bromodiphenhydramine Brompheniramine Carbinoxamine Chlorpheniramine Dexchlorpheniramine Diphenhydramine Doxylamine Phenindamine Pheniramine Phenyltoloxamine Pyrilamine Promethazine Triprolidine

Decongestants—Decongestants produce a narrowing of blood vessels. This leads to clearing of nasal congestion. However, this effect may also increase blood pressure in patients who have high blood pressure. These include:

Ephedrine Phenylephrine Pseudoephedrine

Antitussives—Antitussives help relieve coughing and are some contain a narcotic. These antitussives act directly on the cough center in the brain. Narcotics may become habit-forming, causing mental or physical dependence, if used for a long time. Physical dependence may lead to withdrawal side effects when you stop taking the medicine.

Narcotic antitussives Codeine Dihydrocodeine Hydrocodone Hydromorphone

Non-narcotic antitussives Carbetapentane Caramiphen Dextromethorphan

Expectorants—Expectorants work by loosening the mucus or phlegm in the lungs. The main expectorant used in cough and cold medicines is guaifenesin. Other ingredients added as expectorants (for example, ammonium chloride, calcium iodide, iodinated glycerol, ipecac, potassium guaiacolsulfonate, potassium iodide, and sodium citrate) have not been proven to be effective. In general, the best thing you can do to loosen mucus or phlegm is to drink plenty of water.

Analgesics—Analgesics are used in these combination medicines to help relieve the aches and pain that may occur with the common cold. These include:

Acetaminophen Aspirin Other salicylates such as salicylamide and sodium salicylate

The use of too much acetaminophen and salicylates at the same time may cause kidney damage or cancer of the kidney or urinary bladder. This may occur if large amounts of both medicines are taken together for a long time. However, taking the recommended amounts of combination medicines that contain both acetaminophen and a salicylate for short periods of time has not been shown to cause these unwanted effects.

Anticholinergics—Anticholinergics, such as homatropine may help produce a drying effect in the nose and chest.

These cough and cold combinations are available both over-the-counter (OTC) and with your doctor's prescription.

Do not give any over-the-counter (OTC) cough and cold medicine to a baby or child under 4 years of age. Using these medicines in very young children might cause serious or possibly life-threatening side effects .

Dosage

Usual Adult Dose for Allergic Rhinitis:

desloratadine-pseudoephedrine 5 mg-240 mg oral tablet, extended release: one extended release tablet orally once daily

Usual Pediatric Dose for Allergic Rhinitis:

Detailed Allerdain-D 24 Hour dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose may cause anxiety, trouble sleeping, headache, vomiting, thirst, muscle weakness, fast or pounding heartbeats, hallucinations, shallow breathing, or a seizure.

Storage

Store at room temperature 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Allerdain are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Desloratadine and pseudoephedrine combination is not recommended for use in pediatric patients under 12 years of age.

Do not give any over-the-counter (OTC) cough and cold medicine to a baby or child under 4 years of age. Using these medicines in very young children might cause serious or possibly life-threatening side effects .

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A nine-year-old boy died from rabies encephalitis caused by a rabies virus variant associated with insectivorous bats. Different therapeutic options can be proposed for patients with glenoid loosening. Thus, GATA3 plays important roles in the maintenance of the Th2 phenotype and continuous chromatin remodeling of the specific Th2 cytokine gene locus through cell division. They were also indistinguishable from the heat shock proteins in limited proteolysis. The study shows underreporting of NNT in the existing IDSR system. To evaluate the FAST (focused assessment with sonography in trauma) examination for determining traumatic pericardial effusion and intraperitoneal fluid indicative of injury in patients with penetrating anterior chest trauma. However, a number of studies have shown that communities with well-established control programs are beginning to demonstrate this pattern.

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Reimplantation of hybrid cochlear implant users with a full-length electrode after loss of residual hearing. Sub-cellular fractionation shows that a significant amount of Dnmt2 is bound to the nuclear matrix. Circulating endothelial progenitor cells in systemic sclerosis: association with disease severity. These results show for the first time in teleosts a differential distribution and regulation of two functional AQP1 homologs in the intestinal epithelium, which suggest that they may play specialized functions during water movement across the intestine. Participants were 179 nonsmoking, normotensive men and women aged 18-49 years. Published and yet unpublished results obtained in the Laboratory of Experimental Hepatology, IKEM, since 2002, are presented at the end. It suppresses tumor growth and reduces metastases in animal experiments.

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Haematological evaluation of sodium fluoride toxicity in oryctolagus cunniculus. However, the good correlation between alterations in ADC and AQP4 immunostaining suggests that changes in the AQP4 are involved in some of the early changes in brain water distribution observed in hypoxia-ischemia, and supports the speculation that AQP4 is involved in the transport of water across the perivascular membranes into the vascular lumen. A technique for fast application of heated solutions of different doxepin 3 mg tablet composition to cultured neurones. Most evidence found was from small-group and individual case studies. Parental attitudes about a pregnancy predict birth weight in a low-income population. To find predictive markers of genital dysplasia in women infected with HIV.

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