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Alfacal (Calcitriol)

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Alfacal is the active form of vitamin D, normally made in the kidney. It is also known as 1,25-dihydroxycholecalciferol. It is a hormone which binds to and activates the vitamin D receptor in the nucleus of the cell, which then increases the expression of many genes.

Other names for this medication:
Alfabond, Alfacal, Alfacalcirol, Arachitol, Calasto, Calbec, Calbovic, Calcicare, Calcigra, Calcitriol, Calfa, Calosto, Calzem, Coecoral, Denscal, Duracal, Estovon, Kurecal, Lctrol, Netxod, Novadee, Nutribone, Osteobel, Primacal, Riecal, Rolsical, Septriol, Sorvate, Statbone, Sunmic, Zaxial

Similar Products:
Seroquel, Vantin, Epivir, Micardis, Bactrim, Aldinir, Triopil, Hymin, Biascor, Bisocombin, Mezatrin, Anxigo,

Also known as: Calcitriol


Generic Alfacal is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Alfacal are intestine and bone. Generic Alfacal receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Alfacal may also act on the kidney and the parathyroid glands. Generic Alfacal is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Alfacal has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Alfacal, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Alfacal in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Alfacal produces other independent beneficial effects. Alfacal is also known as Calcitriol. Generic Alfacal treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Alfacal is Calcitriol. Brand name of Generic Alfacal is Alfacal.


This section provides information on the proper use of a number of products that contain vitamin d and related compounds. It may not be specific to Alfacal. Please read with care.

For use as a dietary supplement:

Do not take more than the recommended daily amount. Vitamin D is stored in the body, and taking too much over a period of time can cause poisoning and even death.

If you have any questions about this, check with your health care professional.

For individuals taking the oral liquid form of this dietary supplement:

This preparation should be taken by mouth even though it comes in a dropper bottle. This dietary supplement may be dropped directly into the mouth or mixed with cereal, fruit juice, or other food.

While you are taking alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, doxercalciferol or paricalcitol , your health care professional may want you to follow a special diet or take a calcium supplement. Be sure to follow instructions carefully. If you are already taking a calcium supplement or any medicine containing calcium, make sure your health care professional knows.

The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For alfacalcidol To treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For parenteral dosage form (injection): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 12 mcg a week. To treat diseases in which calcium is not used properly by the body: For oral dosage form (capsules): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 0.25 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day.

For calcifediol To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults, teenagers, and children over 10 years of age—At first, 300 to 350 micrograms (mcg) a week, taken in divided doses either once a day or every other day. Your doctor may change your dose if needed. Children 2 to 10 years of age—50 mcg a day. Children up to 2 years of age—20 to 50 mcg a day. To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage forms (capsules and solution): Adults, teenagers, and children—At first, 0.25 micrograms (mcg) a day. Your doctor may change your dose if needed. For parenteral dosage forms (injection): Adults and teenagers—At first, 0.5 mcg injected into a vein three times a week. Your doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For dihydrotachysterol To treat diseases in which calcium is not used properly by the body: For oral dosage forms (capsules, solution, or tablets): Adults and teenagers—At first, 100 micrograms (mcg) to 2.5 milligrams (mg) a day. Your doctor may change your dose if needed. Children—At first, 1 to 5 mg a day. Your doctor may change your dose if needed.

For doxercalciferol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—10 micrograms (mcg) three times weekly at dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For ergocalciferol The amount of vitamin D to meet normal daily recommended intakes will be different for different individuals. The following information includes only the average amounts of vitamin D. To prevent deficiency, the amount taken by mouth is based on normal daily recommended intakes: For oral dosage form (capsules): For the U.S. Adults and teenagers—5 to 10 micrograms (mcg) (200 to 400 Units) per day. Pregnant and breast-feeding females—10 mcg (400 Units) per day. Children 4 to 10 years of age—10 mcg (400 Units) per day. Children birth to 3 years of age—7.5 to 10 mcg (300 to 400 Units) per day. For Canada Adults and teenagers—2.5 to 5 mcg (100 to 200 Units) per day. Pregnant and breast-feeding females—5 to 7.5 mcg (200 to 300 Units) per day. Children 7 to 10 years of age—2.5 to 5 mcg (100 to 200 Units) per day. Children 4 to 6 years of age—5 mcg (200 Units) per day. Children birth to 3 years of age—5 to 10 mcg (200 to 400 Units) per day. To treat deficiency: Adults, teenagers, and children—Treatment dose is determined by prescriber for each individual based on severity of deficiency. To treat diseases in which calcium and phosphate are not used properly by the body: Adults and teenagers—At first, 1000 to 500,000 Units a day. The doctor may change your dose if needed. Children—At first, 1000 to 200,000 Units a day. The doctor may change your dose if needed.

For paricalcitol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—1 to 2 micrograms (mcg) one time per day or 2 to 4 mcg three times a week (not more often than every other day). The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor. For parenteral dosage form (injection): Adults—0.04 to 0.1 micrograms (mcg) per kg no more than every other day during dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.


If you overdose Generic Alfacal and you don't feel good you should visit your doctor or health care provider immediately.


Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Side effects

The most common side effects associated with Alfacal are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


It is especially important that you receive the right amounts of vitamins so that your baby will also get the vitamins needed to grow properly. Infants who are totally breast-fed and have little exposure to the sun may require vitamin D supplementation. However, taking large amounts of a dietary supplement while breast-feeding may be harmful to the mother and/or baby and should be avoided.

Only small amounts of alfacalcidol, calcifediol, calcitriol, or dihydrotachysterol pass into breast milk and these amounts have not been reported to cause problems in nursing babies.

It is not known whether doxercalciferol or paricalcitol passes into breast milk. Be sure you have discussed the risks and benefits of the supplement with your doctor.

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A prospective cohort study of 556 women in Perth, Western Australia and 503 women from the Darling Downs area, Queensland, Australia. This difference is discussed in terms of local production of IgE and passive diffusion into serum and nasal secretions. Countering this are concerns that human occupation and use of natural reserves is incompatible with conservation aims. This study focuses on the role of the target tissue on the regeneration of afferent peripheral nerves. In this first report, the incidence of leukaemia in children aged 0-14 is presented from cancer registries in 20 European countries for the period 1980-1988. There is evidence that the effect of estrogen on bone is greater than that of testosterone in men.

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In addition to its function as a conventional transcription factor, FOXM1 transactivates the human c-myc P1 and P2 promoters directly via their TATA-boxes by a new transactivation mechanism, which it also employs for transactivation of the human c-fos, hsp70 and histone H2B/a promoters. The present results suggest that the RA-induced apoptosis of NBL cells is associated with activation of both the caspase cascade and the p53-mediated pathway with its nuclear translocation. Processing of clustered DNA damage generates additional double-strand breaks in mammalian cells post-irradiation. None of 12 control patients, many with ophthalmoparesis, showed increased optokinetic nystagmographic amplitude. Strontium-85 in differential diagnosis of bone neoplasms in children and adolescents. Molecular cloning and characterization of peroxiredoxin from Toxoplasma gondii. The purpose of this study was to describe the prevalence of herbal use in a sample of perimenopausal women and to explore disclosure of use to their clinicians. Under local or epidural anaesthesia, radio frequency electrodes were percutaneously introduced with ultrasound guide into the tumor in the liver for ablation.

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Automatic detection of end systole within a sequence of left ventricular echocardiographic images using autocorrelation and mitral valve motion detection. A longitudinal study of change in parental child caregiving involvement. Introduction of a kinase-defective mutant of BREK into i drink alcohol while taking zithromax PC12 cells enhanced both ERK phosphorylation and neurite outgrowth in response to NGF, suggesting that BREK is a negative regulator of NGF-induced neuronal differentiation. When a phonetic dimensions was compared to an auditory dimension, different patterns of results were obtained in both the reaction time and evoked potential data. Body size, body composition, and metabolic profile explain higher energy expenditure in overweight children.

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Nonablative radiofrequency for active acne vulgaris: the use of deep dermal heat in the treatment of moderate to severe active acne vulgaris (thermotherapy): a report of 22 patients. Recently, intrinsic atenolol 25 mg dosage signal optical imaging has been widely used as a routine procedure for visualizing cortical functional maps. Bioaugmentation and coexistence of two functionally similar bacterial strains in aerobic granules. The 310-kDa antigen recognized by mAb 12C11 (denoted Ag 12A) does not correspond to PfEMP2 or the 320-kDa antigen recognized by mAbs 33G2 or 41E11. Likelihood of left main coronary artery compression based on pulmonary trunk diameter in patients with pulmonary hypertension.

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Chronic ethanol ingestion in rats and humans results in significant alterations in sex steroid levels and expression of sex hormone-dependent phenotype. The RAD52(1--192) mutant had only two thermal transitions at 47.6 and 100.9 degrees C (labeled B and C). Caspases are a family of cysteine proteases that are expressed as inactive zymogens and undergo proteolytic maturation in a sequential manner in which initiator caspases cleave and activate the effector caspases 3, 6 and 7. Surgical exploration of the cerebellum discovered a medulloblastoma. In reinnervated muscles of vitamin E deficient rats, sprouting and polyinnervation are increased with respect to reinnervated controls. The optimal embolic endpoint for uterine artery embolization (UAE) is unknown. The presence of CRABP II in postnatal OE and its absence from mature retina is consistent with previous reports indicating that the distribution of CRABP II in adult mammals is restricted to tissue systems that exhibit ongoing growth and differentiation throughout life.

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However, because receptor expression is low on these cells, its functional role is still controversial. The oxygen exchange reaction obeyed a random, sequential mechanism, indicating that the dissociation of the enzyme.DA complex is much faster than the rate-limiting step in the overall exchange process. The frequency, course and clinical significance of changes in regional cerebral blood flow (rCBF) during bacterial meningitis were investigated in 14 adult patients. It appears, therefore, that cognitive vulnerability to depression is best conceptualized as a dimensional construct, present to a greater or lesser glimepiride 4 mg price uk extent in all individuals. A total of 29,133 men ages 50 to 69 years participated in a population-based trial in Finland. Objective and clinically applicable methods for the determination of the normohydration status on an individual basis are needed to help in the identification of an appropriate target weight. This study was designed to examine whether nostril dilatation would affect the ventilatory muscle (VM) function and the mean power output (PO) during prolonged all-out intermittent exercise. Mass spectrometry based peptide mass fingerprints (PMFs) offer a fast, efficient, and robust method for protein identification.

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The framework mandates explicit evidence summaries, ratings of the quality of evidence, and specifying recommendations as strong or weak. Therapy for persistent HPT, if considered, should be initiated 3 months post-transplantation since further spontaneous improvement of parathyroid function thereafter is limited. Calcium-binding property of cocaine and some of its active metabolites-formation of molecular complexes. Variable associations were analysed using the Mann-Whitney, Kruskal-Wallis, Chi-square tests and multiple linear regression. Three well-known methods, namely, multicanonical algorithm, simulated tempering, and replica-exchange method, are described first. This paper reviews and argues the biological plausibility for a periodontal infection-systemic disease link and reviews the available experimental data from animal models and human intervention trials. A serial study of regional cerebral blood flow deficits in patients with left anterior thalamic infarction: anatomical and neuropsychological correlates. For vaginal sialic acid content and concentration, the synergism between oestrogen and progesterone was found to be greater in the presence than in the absence of GH and the maximum response to GH was obtained when between para que sirve el enalapril tabletas 10 mg 20 and 100 mug GH was administered daily. Cumulative white matter changes in the gerbil brain under chronic cerebral hypoperfusion.

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A complete skin physical examination and a direct mycological examination and culture when Onychomycosis was suspected, were performed. Currently applied as an adjunct to other cardiac operations, these new approaches are being modified for thoracoscopic, minimally invasive, epicardial AF ablation. Possibilities of broad spectrum analysis of gene expression patterns with cDNA arrays. Comparable changes occurred in cells that were exposed to recombinant hIL-10 or cmvIL-10. Interviews were conducted with 21 stakeholders representing a wide range of viewpoints to evaluate seven core and 13 discretionary policy options under different criteria. One hundred thirty-two patients with the diagnosis of brucellosis. The determination of free sialic acid in the presence of the bound compound. An in vivo radiographic method to determine teat canal anatomy has shown that resistant quarters had teat canals with a smaller diameter than that of susceptible quarters. During year 2000, we performed an interview survey on 160 HIV-seropositive patients attending Out-Patient Division, King Chulalongkorn Memorial Hospital. Many studies have tried to uncover the pathophysiology behind NTIS and several theories are proposed.

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Malignant transformation of a gangliocytoma/ganglioglioma into a glioblastoma multiforme: a molecular genetic analysis. Management and sequelae after misapplied intrathecal dactinomycin. Primary structure and reactive site of a novel wheat proteinase inhibitor of subtilisin and chymotrypsin. Histologic changes of the myocardium after heart transplantation. Successful rehydration of surfactant to produce niosomes from dried film requires that the film be as thin as possible to avoid the clumping and precipitation that occurs when pure, granular surfactant is hydrated directly. The study showed that cisplatin and 5-fluorouracil have a low order of activity in patients with advanced or disseminated melanoma. A clinical prospective study was carried out to compare 2 flap designs-marginal and paramarginal-that are used during impacted third molar surgery. High-intensity zone, intradiscal electrothermal therapy, and magnetic resonance imaging. Oral treponemes in primary root canal infections as detected by nested PCR. Niflumic acid produced the most pronounced growth aberrations which may reflect an ability to acidify the cytoplasm and block the plasma membrane anion channel of N.

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These results indicate that the venom from Habu-kurage has both vasoconstrictor and cardiodepressive effects, and suggest that these thermolabile actions may be due partly to activation of voltage-dependent calcium channels and probably subsequent calcium-overload. Since the landmark pilot study of Fujiwara, published more than 20 years ago, the efficacy of exogenous surfactant for the treatment of neonatal RDS has been established by numerous controlled studies and meta-analyses. Substantial amounts of MP were regenerated from both prodrugs in the liver and spleen, with the rate of release from DMP-5 being twice as fast as that from DMP-1. From the roots of Trachomitum sarmatiense Woodson (Apocynaceae) 5 cardial glycosides were isolated. High-spatial-resolution 3D balanced turbo field-echo technique for MR angiography of the renal arteries: initial experience. Eighteen relapsing-remitting MS patients were evaluated: depression was diagnosed according to DSM-III R and measured by the MMPI depression subscale, physical disability was assessed by using the Kurtzke Expanded Disability Status Scale (EDSS) and cognitive functions by means of an extensive neuropsychological test battery.

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Visual exteroceptive information provided during obstacle crossing did not modify the lower limb trajectory. The research involved 451 early adolescents and their families and used a prospective, longitudinal research design with multi-informant methods. Some of these roles may include long-distance signalling within and perhaps between plants. Only one child in the sample was readmitted to the PEAU within 24 hours, and two within 24 hours of discharge as inpatients. Effect of prednisone priming followed by alfa-interferon in treatment of children with chronic hepatitis B: an interim analysis of a controlled trial. Clinical practice guidelines, systematic reviews, meta-analyses, and single studies. Progesterone only contraception has only very few contraindications which are only relative. Actual PTX volumes were measured by means of manual aspiration of air present in the pleural space in 18 patients with primary spontaneous PTX and correlated with the size estimation obtained by the Light index. Changes in cardiac membranes as a function of age with particular emphasis on reactivity to drugs. Communicator image and Myers-Briggs Type Indicator extraversion-introversion.

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However, the results of our study indicate that there is no clear pathophysiological significance, irrespective of genotype, supporting the claim that SCADD is not suited for inclusion in newborn screening programs. Activation of both could be transiently blocked by administration of a recombinant chimeric TNF-alpha receptor antagonist (rhTNFR:Fc). Involvement of the peripheral nerve must be identified and requires surgical treatment, which can provide good results for pain and function. Luminescent CdSe/CdS core/shell nanocrystals in dendron boxes: superior chemical, photochemical and thermal stability. Gas chromatography/mass spectrometric identification of dopaminergic metabolites in striata of rats treated with L-DOPA. Deoxyribonucleic acid (DNA) extraction was done, followed by polymerase chain reaction (PCR) to detect the presence of human papillomavirus (HPV). Ours and other recent studies suggest a small but consistent increased risk of lung cancer from passive smoking. However, it is still not known whether the changes in the expression and/or responsiveness of beta-adrenoceptors are adaptive or maladaptive. Thus instability and infection of the osteotomy site were avoided. We find that intensive early blockade of CD40L reliably attenuates acute rejection of primate cardiac allografts.

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