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Alcicalm (Alprazolam)
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Alcicalm

Alcicalm is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder. It's also used in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Alcicalm, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Alcicalm is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Allam, Alpram, Alprawin, Alpron, Alprop, Alprose, Alzac, Alzom, Anxiflu, Anxigo, Apsolam, Censir, Depten, Destres, Diprex, Endolam, Maxorest, Nokzok, Prazil, Prolam, Restam, Rozin, Serex, Sinaday, Stresnil, Tenan, Tenolam, Tryzo, Unixl, Wycalm, Xylonite, Zotin

Similar Products:
Temovate, Zyvox, Medrol, Lodine, Persantine, Artane, Trileptal, Dubolut, Ropinirole, Alpramax, Dytor, Xenith, Normozide, Zencid, Vogipax, Medozide, Tofranil,

Also known as: Alprazolam

Description

Alprazolam is used to relieve symptoms of anxiety, including anxiety caused by depression. It is also used to treat panic disorder in some patients.

Alprazolam is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system.

This medicine is available only with your doctor's prescription.

Dosage

Usual Adult Dose for Anxiety:

Immediate-release tablets: 0.25 to 0.5 mg orally administered 3 times a day -Maximum dose: 4 mg/day

Usual Adult Dose for Panic Disorder:

Immediate-release tablets: 0.5 mg orally administered 3 times a day -Maximum dose: 10 mg/day Extended-release tablets: -Initial dose: 0.5 to 1 mg orally once a day -Maintenance dose: 3 to 6 mg orally per day, preferably in the morning -Maximum dose: 10 mg/day Comments: -The lowest possible effective dose should be administered and the need for continued treatment reassessed frequently. -Dosage should be reduced gradually when discontinuing therapy or when decreasing the daily dosage. -The daily dosage may be decreased by no more than 0.5 mg every 3 days; however, some patients may require an even slower dosage reduction. -The dose of extended-release tablets may be increased at intervals of 3 to 4 days in increments of no more than 1 mg per day. -The times of administration should be distributed as evenly as possible throughout the waking hours.

Usual Geriatric Dose for Anxiety:

Elderly or debilitated patients: Immediate-release tablets: 0.25 mg orally administered 2 or 3 times a day.

Usual Geriatric Dose for Panic Disorder:

Elderly or debilitated patients: Immediate-release tablets: -Initial dose: 0.25 mg orally administered 2 or 3 times a day Extended-release tablets: -Initial dose: 0.5 mg orally once a day Comments: -If side effects develop, the dose may be lowered. -The lowest possible effective dose should be administered and the need for continued treatment reassessed frequently. -Dosage should be reduced gradually when discontinuing therapy or when decreasing the daily dosage.

Detailed Alcicalm dosage information

Overdose

If you have been prescribed Alcicalm for medical reasons, the best way to avoid a Alcicalm overdose is to adhere to prescribed orders—closely monitor your dose and the time at which you take your medication. Track your Alcicalm consumption in a notebook or on your phone. If you notice that you are taking a higher dose of the drug, taking the drug more often, or you want to consume more of the drug, talk with your doctor immediately.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details.

Side effects

The most common side effects associated with Alcicalm are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not take Alcicalm if:

you also take itraconazole or ketoconazole (antifungal medicines); or you have a history of allergic reaction to any benzodiazepine (alprazolam, diazepam, lorazepam, Ativan, Klonopin, Restoril, Tranxene, Valium, Versed, and others).

To make sure Alcicalm is safe for you, tell your doctor if you have ever had:

breathing problems such as COPD (chronic obstructive pulmonary disease) or sleep apnea (breathing that stops during sleep); drug or alcohol addiction; depression, mood problems, or suicidal thoughts or behavior; or kidney or liver disease (especially alcoholic liver disease).

Tell your doctor if you are pregnant or plan to become pregnant. Alprazolam may harm an unborn baby. Avoid taking this medicine during the first trimester of pregnancy.

If you use Alcicalm while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks.

You should not breastfeed while using alprazolam.

Alcicalm is not approved for use by anyone younger than 18 years old.

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Sensitivity of acid-adapted and acid-shocked Shigella flexneri to reduced pH achieved with acetic, lactic, and propionic acids. In clinical studies, formoterol was well tolerated and had an adverse-event profile similar to that of other beta2-adrenergic receptor agonists. Pulmonary muscle strength, pulmonary function tests, and dyspnea in women with major depression. Combined intraperitoneal and intravenous chemotherapy for women with optimally debulked ovarian cancer: results from an intergroup phase II trial. A one-day desensitization protocol was successfully administered that permitted continuation of angiography for deteriorating vision. Contrasting regulation of fecundity in two abomasal nematodes of Svalbard reindeer (Rangifer tarandus platyrhynchus). In the present study, we demonstrate that nonspecific immunostimulation augments host resistance against the lethal toxicity of 5-FU in tumor-bearing mice. A comparative analysis was made of quantitative characteristics of nucleoli of two functionally different cell types: the apical cells of meristematic nature, and specialized cells resulting from mitotic cycle of suspensory cells. A transbronchial lung biopsy specimen obtained from near the cavitary lesion revealed non-caseating granulomas compatible with sarcoidosis.

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Small interfering RNA (siRNA) is currently being evaluated not only as a powerful tool for functional genomics, but also as a potentially promising therapeutic agent for cancer and infectious diseases. Using anti-TCR mAb we isolated and characterized the specific two-dimensional MHC-CD8 binding from the trimolecular TCR-MHC-CD8 interaction. More studies are needed to demostrate significant reduction in the incidence of ulcers. Plasma total cysteine (t-Cys) is significantly lower in the third compared to the second trimester. Kalirin-7 also interacts with AMPA receptors and controls their synaptic expression. The association of p59fyn with the zeta chain was specific, as two closely related Src family protein tyrosine kinases, p60src and p56lck, did not associate with a chimeric protein that contained the cytoplasmic domain of zeta. To compare the rates of bleeding complications in patients with renal insufficiency who receive anticoagulation therapy with the full therapeutic dose, unfractionated heparin (UFH), or with twice-daily enoxaparin. In contrast, radiation chimeras reconstituted with RelA or TNFR1/RelA-deficient hemopoietic cells were healthy and demonstrated no defect in neutrophil emigration during LPS-induced pneumonia. Engineering antitumor immunity by T-cell adoptive immunotherapy. in a calcium phosphate buffer and the Ca and P content were measured.

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HE2000 reduced mortality related to excessive inflammation and opportunistic lung infections in animals and patients, and this might extend to those with H1N1 influenza infection. A plasmid-based reverse genetics system for animal double-stranded RNA viruses. Brain IL-1 beta was involved in reserpine-induced behavioral depression in rats. The effects of eicosanoids and specific enzyme inhibitors were assessed. This article deals with duration of and changes in drug treatment of nursing home residents. Thyrotropin-releasing hormone (TRH) initiates its effects by interacting with cell-surface membrane receptors. This is the first study to show a possible link between stressful life events and episodes of seborrheic dermatitis. It acts as a receptor for neurotensin, but predominates in regions of the nervous system that neither synthesize nor respond to this neuropeptide, suggesting that sortilin has additional roles. Peroneal mononeuropathy: predisposing factors, and clinical and neurophysiological relationships. The concentrations of MT and both cytosolic and insoluble metals were not greatly different between males and females, and the influence of organ weights was also minimal.

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A comparison with representatives of all groups of metabotropic bioamine receptors from vertebrates and invertebrates showed that none of these receptors clusters together with any of the four groups of vertebrate histamine receptors. Contours mark changes and transitions in sound and auditory cortex appears particularly sensitive to these dynamic aspects of sound. At pH 6.0 the reaction was slow and at pH 1.9 little or no transpeptidation was observed. Finally, we demonstrate that the system metMb/H(2)O(2)/NO(2)(-) can also lead to the nitration of tryptophan and produces, in particular, 6-, 4-, and 5-nitrotryptophan. In this study, the thyroid hormone thyroxine (T(4)) was used to induce these changes in trout parr. To the expert, it presents visual and haptic tools that make illustrating procedures easy and can model unusual anatomic variations. Laparoscopic management of acute abdomen is a safe and effective method with the advantages of small scar, short hospital stay and early recovery. In addition, 5 per cent L-glutamine replaced L-glutamic acid on an isonitrogenous basis in three diets containing normal levels of amino acids in the second study.

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