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Afeditab (Nifedipine)

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Afeditab is a drug that performs by relaxing the muscles inside the heart and blood vessels in order to enable easier blood flow. This enables the heart to have an easier time pumping blood. The active ingredient is nifedipine and it a part of a class of drugs called calcium channel blockers. The primary use of this medication is to help stop chest pain (angina) and help treat high blood pressure problems (hypertension). In addition to this it can also be used in order to heighten the supply of oxygen and blood to the heart and help with a specific blood circulation condition called Raynaud’s phenomenon.

Other names for this medication:
Addos, Amarkor, Atanaal, Atenerate, Belnif, Cardalin, Cardicon, Cardipin, Cobalat, Conetrin, Coracten, Depicor, Epilat, Farmalat, Jutadilat, Lemar, Macorel, Marivolon, Milfadin, Nelapine, Nidilat, Nifangin, Nifecap, Nifecor, Nifed, Nifelong, Nifeslow, Nifestad, Nifin, Nirena, Nycopin, Sidalat, Siopelmin, Tensopin, Valni, Viscard, Xepalat

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Also known as: Nifedipine


Nifedipine is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Nifedipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, nifedipine relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain nifedipine. It may not be specific to Afeditab XL. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended release tablet whole. Do not break, crush, or chew it. It is best to take this tablet on an empty stomach.

If you are taking the extended-release tablets, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of chest pain or high blood pressure: For oral dosage form (capsules): Adults—At first, 10 milligrams (mg) three times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 30 or 60 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 90 mg once a day. Children—Use and dose must be determined by your doctor.


If you overdose Afeditab and you don't feel good you should visit your doctor or health care provider immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Afeditab dosage information

Side effects

The most common side effects associated with Afeditab are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of nifedipine in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems which may require caution and an adjustment in the dose for patients receiving nifedipine.

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Endoscopy is still the gold standard diagnostic method for diagnosing esophageal varices in patients with cirrhosis. The molecular identity was confirmed by comparison of the deduced amino acid sequence with the directly determined primary structure of salmosin. Forty-two centers consisting of large institutional primary care programs and academic centers, including pain centers, neurologists, and pain specialists affiliated with a university. Incorporating the effects of socioeconomic uncertainty into priority setting for conservation investment. A double purse-string suture was placed on the aorta of 3 pigs via a thoracoscopic approach.

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Optical and ultrastructural changes in the rabbit lens caused by microwaves. Histochemical detection of lymphatic drainage pathways in the middle nasal meatus. The DNA alkylating agent, N-methyl-N-nitrosourea (MNU), when administered prenatally (on day 16 of gestation) provokes a progressive retinal degeneration in CD-1 albino mice reared in standard fluorescent lighting conditions (12 L: 12 D). Blood was sampled every 10 min during their first complete sleep cycle for simultaneous measurements of plasma ET-1, PRA and ANP. The method is not sensitive to misadjustments or inhomogeneities of the B1 field, but sufficient homogeneity of the static magnetic field B0 is required.

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Individuals with PWS characteristically have poor feeding and lack of appetite in infancy, followed by the development of weight gain and then uncontrolled appetite and lack of satiety, sometime after the age of two. In contrast, Fluoro-Jade staining was gradually increased in these degenerative axons from 2-7 dpi. These results thus limit the potential impact of the heptavalent pneumococcal conjugate vaccine on the frequency of pleural empyemas in children. Eurasian blackbird predated by wild Rhinopithecus roxellana in the Qinling Mountains, China. Such variations in SADA observed in the 40 patients with lung carcinomas support our previously published clinical results, confirming that the variations of SADA could be a reliable marker for the therapeutic monitoring of different human malignancies. The value of assisted circulation in case of the hitherto only difficulty to controlled failure of the right ventricle is proved with that. Antifreeze proteins (AFP) are able to inhibit the growth of ice-crystals at temperatures below the equilibrium freezing point (Tf) of hemolymph. While environmental AHR ligands can mediate this effect, endogenous ligands are likely to be more relevant in host immune responses.


The application of augmented reality in the surgical field makes it possible to do a neurosurgical intervention easily and accurately. While PEPT1 is specific for early regions of the proximal tubule (pars convoluta), PEPT2 is overwhelmingly but not exclusively expressed in latter regions of the proximal tubule (pars recta). The aging of the heart and blood vessels: a consideration of anatomy and physiology in the era of computed tomography, magnetic resonance imaging, and positron emission tomographic imaging methods with special consideration of atherogenesis. This model-based economic analysis demonstrates that in the Netherlands and most likely also in the United States, if secondary prophylaxis is preferred, the strategy with antibiotics is recommended. Influence of pH on metabolism and urease activity of Helicobacter pylori. Postprocedural bleeding is a rare but life threatening complication of endoscopic cystogastrostomy which may require surgical management in some patients.

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Here E(beta) is the glassy state activation enthalpy of the Johari-Goldstein beta relaxation, T(g) is the glass transition temperature of the alpha relaxation, and R is the gas constant. This suggests that OsSSIIIa/Flo5 plays an important role in generating relatively long chains in rice endosperm. Clinical ease of usage of the wire tensioners was also evaluated. When the patient in a HNPCC family develops adenoma with microsatellite mistability, preventive colectomy might be one of the surgical option with the informed consent of the patient. Survival after resection of extrahepatic cholangiocarcinoma is significantly impacted by AJCC stage, the use of adjuvant therapy, and in patients with proximal tumors, the need for concomitant hepatectomy. A rot sae sarT triple mutant was not able to rescue the hla defect of the rot sae double mutant. Transient overexpression of TIEG1 activated the CD11d promoter specifically in myeloid cells, whereas, down-regulation of TIEG1 with small interfering TIEG1 RNA also down-regulated expression of CD11d. The bulk of the results showed that both n-6 PUFAs and n-3 PUFAs decrease human lung-tumor cell growth in a concentration-dependent manner, inducing cell death mainly evident at 100microM concentration. Finally, some of these proteins were found to be adherent to intestinal epithelial cells in vitro.

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From the Netherlands Cancer Registry, World standardized incidence rates per municipality were smoothed calculating weighted averages for each 2 km by 2 km grid of the population mid-points of neighbouring municipalities and presented as map animations. A 54-year-old female patient was hospitalized with a chief complaint of anal discomfort. This study involved 109 consecutive patients with 114 intraintestinal or extraintestinal mass lesions and/or peri-intestinal lymph nodes. Surgical resection after radiosurgery is indicated in the presence of such symptoms as cerebellar ataxia and increased intracranial pressure. Concordance was found in all but three patients, with solitary superficial grade II bladder tumors less than 2 mm in diameter that were overlooked at flexible cystoscopy. However, mRNA levels of group IVA, VIA, or VIB PLA(2) did not change. Before the occurrence of convulsion confirmed by behavior and EEG, the mossy fiber sprouting was found in the PTZ group. The differential effect of mannitol in asthma versus COPD, may relate to the specific pathologic features of the diseases. Recently, on the basis of the unusual DNA sequence organization of the DRD4 7R 48-bp tandem repeat (VNTR), we proposed that the 7R allele originated as a rare mutational event that increased to high frequency by positive selection.

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Deletion of the PDZ binding motifs impair VSV-delta-PDE subcellular distribution. We found macroscopic cavities in 32 of the defects which communicated with the adjacent facet joints and had fibrous capsules. We report on a comprehensive photoelectron spectroscopy and photoelectron diffraction study that reveals the weak interaction of silicon nano-ribbons with the underlying silver substrate identifying the specific locations of the individual silicon, as well as silver atoms. We suggest that the 1-microg ACTH stimulation test replace the conventional 250-microg test when evaluating for central adrenal insufficiency. In 16 cases of primary closure, the defects were closed using simple sutures, and in 7 cases, closure was performed after wide undermining. The primary objective of the present study was to evaluate the educational value of these devices in terms of improving medical student interest and what dose of klonopin to sleep understanding of US and sonographic anatomy. Removal of eye blinking artifacts from EEG incorporating a new constrained BSS algorithm. Dual guar/ionic liquid gels and biohybrid material thereof: rheological investigation. We observed no activation of a cryptic splice site but found that a recurrent missense mutation in exon 7 creates a new splice site (two families). Role of a rigid polyproline spacer inserted between hapten and carrier in the induction of anti-hapten antibodies and delayed hypersensitivity.

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Angiotensin II receptors induce tyrosine dephosphorylation in rat fetal membranes. The free EM66 peptide was obtained by cleavage of the fusion protein followed by high performance liquid chromatography purification. It now seems probable that most cases of pure gonadal dysgenesis in XY women are genetically determined rather than induced by environmental agents. We find that myosin II pulls the rear of the lamellipodial actin network, causing upward bending, edge retraction, and initiation of new adhesion sites. Bladder replacement after radical cystectomy using detubularized right colonic segment. Spectroscopic investigation on kinetics, thermodynamics and mechanism for electron transfer reaction arimidex cost of iron(III) complex with sulphur centered radical in stimulated biological system.

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Clinical toxoplasmosis is most severe in congenitally-infected hosts. The intraperitoneal administration of putrescine (1 or 10 mg/kg body weight), at the time of surgery and at 4 and 8 hr postoperatively partly restored the suppressed hepatocyte deoxyribonucleic acid (DNA) biosynthesis and thymidine kinase activity in cadmium-pretreated partially hepatectomized rats. Totally 40 neurosurgical patients of I-II grade (ASA grading) in our hospital were randomly divided into the TAES group (T group) and the control group (C group), 20 in each group. Effect of synovitis and corticosteroids on transcription of cartilage matrix proteins. Asymmetrical flow field flow fractionation methods to characterize submicron particles: application to carbon-based aggregates and nanoplastics. We also examine whether behavioral sleep-wake cycles, which are driven by the environmental day-night cycles, regulate stem cell function. The acquisition lesion group was unable to acquire the trace conditioned response, suggesting that the whisker barrel cortex is vital for learning trace eyeblink conditioning with whisker deflection as the CS. Treatment of periocular basal cell carcinoma using an advanced stereotactic device. Although the Food and Drug Administration approved the use of the capsule in children (ages 10-18 years) in October 2003, few small clinical trials exploring the diagnostic yield of capsule endoscopy in pediatric populations have been published. Carboxypeptidase-B activation peptide, a marker of pancreatic acinar injury, but not L-selectin, a marker of neutrophil activation, predicts severity of acute pancreatitis.

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An information-theoretic DNA compression scheme devised by Milosavljevic and Jurka (1993) has been used in many places in the literature for both the discovery of new genes and the compression of DNA. The present study evaluated the antidepressant-like effect of the quercetin-rich vegetable, onion, by using the rat behavioral model of depression, the forced swimming test (FST). The main result of the numerical simulations is that in all cases, specific values of coupling strength and asymmetry exist that render the two oscillators periodic and synchronized. Optimal paths in how much is nizoral tablet in nigeria complex networks with correlated weights: the worldwide airport network. Future studies are needed to verify the effects of gabexate in the clinic, especially for kidney transplantation.

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Cryopreservation of rhesus monkey (Macaca mulatta) epididymal spermatozoa before and after refrigerated storage. One important consideration is whether bacteriophage therapy development occurs on an industrial scale or a hospital-based, patient-specific scale. miRNAs are small, noncoding pieces of ribonucleic acid that exert control over gene expression at the posttranscriptional level. The phorbol ester-mediated dephosphorylation of the hydrophobic site, but not the turn motif or activation loop, is insensitive to okadaic acid, consistent with PHLPP, a PP2C family member, controlling the hydrophobic site. coli despite a lack of direct anti-bacterial properties, thus unaffecting the commensal gut microbiota. The genotype of the Brazilian dupA-positive Helicobacter pylori strains is dupA1. Flumazenil for hepatic encephalopathy grade III and IVa in patients with cirrhosis: an Italian multicenter double-blind, placebo-controlled, cross-over study. The immediate purpose of the journal issue is to summarize the best available research and clinical practices on numerous elements of the therapy relationship, but the underlying purpose is to repair some of the damage incurred by the culture wars in psychotherapy and to promote rapprochement between the science and practice communities. Upon exposure for 5 days, differential expression was detected at concentrations as low as 0.22 microM of 3,4-DCA, which was close to the lowest observed effect concentration (0.11 microM) in the 30-day early life stage test.

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By subcloning, a 16 kb DNA region was identified which contains zithromax renal dose the genetic information required to express C. This study was undertaken to investigate the trends in domestic publications on bone metabolism during the last decade, and to document the characteristics of articles in South Korea. Sputum must be examined in all patients with prolonged productive cough, and negative investigations should be repeated. The key idea of the suggested method relies on preserving the order in mean while reducing the dimension of the data. The chronic toxicity of sodium bicarbonate, a major component of coal bed natural gas produced waters. Health practitioners should therefore consider IUDs for contraception in all females. OA cartilage was obtained from knee joints with end-stage OA, at both macroscopically intact areas and areas with various degrees of cartilage degeneration.

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It has been shown previously that osteoblast differentiation and maintenance of bone mass are impaired in endothelial nitric oxide synthase gene knockout mice. It is designed to be utilized with readily available stock computer hardware and software without significant customization or any additional programming. Innervation of the C cells of chicken ultimobranchial glands studied by immunohistochemistry, fluorescence microscopy, and electron microscopy. two groups of adults were surveyed using a specifically designed tool to assess knowledge about fetal abnormalities and potential screening tests, attitudes to screening and termination of pregnancy, and information required by parents before making decisions. Here, we describe the generation and use of planar antibody arrays for serum protein profiling.

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pseudomallei locus tags within the full text and tables of OA publications represent only a small fraction of the total mentions in the literature. In Korea, the risk of CAP is significantly high in military trainees, with low levels of cholesterol and albumin being associated with the development of CAP in young soldiers. In the current study, three dot-probe experiments with fearful and neutral eye stimuli were performed. Capacity and demand theory suggests that the presence of a queue is not necessarily an indication of a shortage of capacity in a system. Here we summarize efforts in our lab to continue this tradition and to further our understanding of how blood cells interact with each other and with the blood vessel wall. Refractive error (RE) is considered to be a possible cause for headaches. Hydrophobicity was considered as sigma f of the variable structural moiety, calculated by the Leo-Hansch method. The distribution of stomata and the portion of CO2-uptake of both leaf surfaces correspond well. Taken together, we have demonstrated that the sialylated milk oligosaccharide sialyllactose functions as an inhibitor of angiogenesis through suppression of VEGF-mediated VEGFR-2 activation in endothelial cells, Accordingly, it could be a novel candidate for the development of anti-angiogenic drugs without any side effects.

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Moreover, dysregulated gene expression in SMYD5 cancer cells was associated with LTR and endogenous retrovirus (ERV) elements and decreased H4K20me3. Overexpression of miR-10 also induces specific phenotypes related to the loss of function of these targets. The proposed methodology incorporates all the available evidence and conflicting objectives to evaluate implications of alternative actions in the decision-making process and suggests best decision pathways under uncertainty. Most common assays for examining caspase-3 activation include immunostaining, immunoblotting for active caspase-3, colorimetric assays using fluorochrome substrates, as well as employing the fluorescein-labeled CaspaTag pan-caspase in situ detection kit. The development of, and results from an image analysis system are presented for automated detection and scoring of micronuclei in human peripheral blood lymphocytes.

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Based on statistical decision theory, our head-to-head study suggests that QuantiFERON-TB Gold In-Tube is the first-line test that should be performed in preference to T-SPOT.TB (and the tuberculin skin test) for diagnosing tuberculous uveitis. Though more variable, mean CYP1A protein levels in the field-collected fish were similar to those of the BaP-induced laboratory fish. The authors have described a new method of coloration on anatomic slices of the central nervous system realised on formolated subjects. Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) were employed to identify the presence of doxorubicin within nanospheres. This model implies a major structural rearrangement for the DNA binding region of lambda integrase, analogous to the structural rearrangements of the DNA binding motifs of other proteins when contacting their target DNA. Regulation of alkaline phosphatase gene expression in human hepatoma cells by bile acids. Marine macroalgal community structure, metal content and reproductive function near an acid mine drainage outflow. Nursing home safety: current issues and barriers to improvement. One remedy is to use the topographic structures to approximate the sample surfaces and produce the unknown molecular structures by means of deformable shape generation methods from the topographic models. A hundred and seventy-one CAD patients from the north-western part of Poland and 200 consecutive newborns from the same population were genotyped by PCR-RFLP.

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