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Afdiex (Glibenclamide)

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Afdiex is a medicine used to treat type 2 diabetes mellitus. It helps control blood sugar levels and thus prevent serious complications of diabetes. It is also used to treat a menstruation-related disorder known as Polycystic ovary syndrome (PCOS) in women.

Other names for this medication:
Aviglen, Betrol, Bionil, Codica, Comdiab, Diabetrol, Euglucon, Eumet, Giclamide, Glibson, Glime, Glimsug, Glinil, Glitrac, Glucored, Glucosafe, Glucosil, Glunil, Glutowin, Glybonil, Glycurub, Iscept, Monomet, Pionorm, Secrin, Sugatrol, Sugnl, Sugronil, Symet

Similar Products:
Zovirax, Persantine, Benicar, Xanax, Vasotec, Rogaine, Chloromycetin, Verben, Zacool, Ortibid, Sebercim, Tetralet,

Also known as: Glibenclamide


This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.


Usual Adult Dose for Diabetes Type 2:

Standard Afdiex: -Initial dose: 2.5 mg to 5 mg orally once a day -Dose titration: Increase in increments of no more than 2.5 mg at weekly intervals based upon blood glucose response -Maintenance dose: 1.25 to 20 mg orally as a single dose or in divided doses -Maximum dose: 20 mg/day Micronized Afdiex: -Initial dose: 1.5 mg to 3 mg orally once a day -Dose titration: Increase in increments of no more than 1.5 mg at weekly intervals based upon blood glucose response -Maintenance dose: 0.75 to 12 mg orally as a single dose or in divided doses -Maximum dose: 12 mg/day Comments: -Administer with breakfast or the first main meal of the day -Lower initial doses may be used in patients who are sensitive to hypoglycemic drugs -Once a day therapy is generally satisfactory, however, some patients may have a more satisfactory response with twice-a-day dosing, especially those receiving higher doses. TRANSFER FROM OTHER HYPOGLYCEMIC THERAPY: -Oral Antidiabetic Therapy: No exact dosage relationships exists between standard Afdiex, micronized Afdiex, or other oral hypoglycemic agents; when transferring patients from other oral hypoglycemic therapy, the maximum starting doses should be observed. -Insulin: --If the insulin dose is less than 20 units per day substitute 2.5 to 5 mg (standard) OR 1.5 to 3 mg (micronized) orally once a day. --If the insulin dose is between 20 and 40 units per day, substitute 5 mg (standard) OR 3 mg (micronized) orally once a day. --If the insulin dose is more than 40 units per day; transition the patient by concomitantly decreasing insulin by 50% and starting Afdiex at 5 mg (standard) OR 3 mg (micronized) orally once a day; as insulin is progressively withdrawn, titrate in increments of 1.25 to 2.5 mg (standard) OR 0.75 to 1.5 mg (micronized) orally once a day every 2 to 10 days. Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Usual Geriatric Dose for Diabetes Type 2:

Initial dose: 1.25 to 2.5 mg (standard) orally or 0.75 to 1.5 mg (micronized) orally once a day.

Detailed Afdiex dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A Afdiex overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, nausea, tremors, sweating, confusion, trouble speaking, fast heartbeats, or seizure.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Side effects

The most common side effects associated with Afdiex are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Avoid drinking alcohol. It lowers blood sugar and may increase your risk of lactic acidosis.

If you also take colesevelam, avoid taking it within 4 hours after you take Afdiex and metformin.

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The impact of symptom on the child: comparative studies of clinical populations. Theoretical predictions for a two-beam illumination pattern in which the relative beam intensity is modulated are compared with computer simulations and experiments performed by illumination of a rotating mask of identical but random apertures. Changes in the lipid fraction of king mackerel pan fried in coconut oil and cooked in coconut milk. MiR-34-a acts as a suppressor in neuroblastoma progression by targeting CD44. How to ensure data security of an epidemiological follow-up: quality assessment of an anonymous record linkage procedure. Effect of activation and blockade of the GABAergic system on disturbance of memory trace reproduction.

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