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Adipine (Nifedipine)

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Adipine is a dihydropyridine calcium channel blocker. Adipine is used to: treat high blood pressure (hypertension), prevent chronic stable angina (chest pain). Adipine was the first calcium channel blocker to be shown to significantly reduce the development of new overt heart failure in patients with coronary artery disease. Excellent blood-pressure control in recent clinical trials has been shown to result in significant protection against stroke. Adipine works by opening up blood vessels in the body to lower blood pressure and improve the supply of blood and oxygen to the heart. Calcium channel blockers do not change the amount of calcium in your blood or bones.

Other names for this medication:
Addos, Atanaal, Bresben, Calchan, Calcigard, Cardifen, Cardiosol, Carditas, Chronadalate, Cisday, Citilat, Conducil, Depin, Duranifin, Emaberin, Herlat, Hexadilat, Macorel, Marivolon, Nedipin, Nifeclair, Nifedipin, Nifelat, Noviken, Sepamit, Tensopin

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Also known as: Nifedipine


Nifedipine is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Nifedipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, nifedipine relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain nifedipine. It may not be specific to Adipine OROS. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended release tablet whole. Do not break, crush, or chew it. It is best to take this tablet on an empty stomach.

If you are taking the extended-release tablets, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of chest pain or high blood pressure: For oral dosage form (capsules): Adults—At first, 10 milligrams (mg) three times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 30 or 60 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 90 mg once a day. Children—Use and dose must be determined by your doctor.


If you overdose Adipine and you don't feel good you should visit your doctor or health care provider immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Nifedipine dosage information

Side effects

The most common side effects associated with Adipine are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of nifedipine in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems which may require caution and an adjustment in the dose for patients receiving nifedipine.

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Analysis of intraspecific diversity of cultivated emmer Triticum dicoccum (Schrank.) Schuebl using C-banding technique. Ionic liquids and deep eutectic mixtures as new solvents for the synthesis of vanadium fluorides and oxyfluorides. Some, but not all, studies have shown that patient-reported health status, including symptoms, functioning, and health-related quality of life, provides additional information to traditional clinical factors in predicting prognosis in heart failure patients. The lipid profiles of these two patients were improved with IPE treatment, illustrating the potentially favorable effects of IPE compared with other products containing both EPA and DHA. In most cases, the valvular abnormality had not been suspected clinically. The target genes of the regulatory cascade include genes of various functions required for morphological development and secondary metabolite formation. Specular microscopy of the anterior lens capsule was performed postoperatively, and the process of anterior capsule opacification after endocapsular cataract surgery was classified.

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Comparative metabolic excretion profile of sodium salicylate in broiler chickens and homing pigeons. The path lengths were significantly reduced in the frontal plane one week after the training end date. The described case showed that a thyroid storm can present as multiple organ failure, requiring intraaortic balloon counterpulsation for the management of catecholamine-resistant shock. Investigation of factors associated with variation in dialysis patient employment has focused primarily on patient-level factors. Antilymphocyte serum: an investigation into the decay phenomenon. The control group received traditional passive stretch and range of motion exercises. We use the simultaneous water and nutrient uptake model to investigate the effect that water movement has on nutrient uptake.

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Long sleep duration was associated with a moderate increase in liver cancer risk in obese postmenopausal women in the United States. Both increased resorption and decreased formation might be involved in the pathogenesis of osteoporosis. Peri-operative dreaming in paediatric patients who receive suxamethonium. Extensive research has been conducted on the development of three groups of naturally occurring antimicrobials as novel alternatives to antibiotics: bacteriophages (phages), bacterial cell wall hydrolases (BCWH), and antimicrobial peptides (AMP). The DeltaG degrees for ET, PT, or PCET has a strong influence on the rate of that step. coli RNA polymerase revealed efficient bypass at the three lesions examined and subsequent generation of full-length runoff transcripts. Reference lists were checked and we contacted experts in the field to identify further published and unpublished studies. Acute care nurses have an important role in the discharge planning of older people from hospital to home.

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Phenolic acid content is associated with the substitution of chromosome DS1D(1H(ch)) and DS2D(2H(ch)), and the translocation 1RS/1BL in tritordeum. Prospective study of consecutive Singaporean patients, aged 21 to 65 years, discharged from the acute inpatient Rehabilitation Medicine Service at Changi General Hospital with a mild-to-moderate physical disability, as determined by discharge Modified Barthel Index score, and their employment status 6 months after discharge. Gene therapy for X-linked severe combined immunodeficiency (SCID-X1) has proven highly effective for long-term restoration of immunity in human subjects. Both pain- and (nonpain) goal-related information attracts attention. A national advertising campaign and snowball sampling were used to recruit nine participants from across Australia.

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The solution-state NMR structure of the first generation helix-less variant, known as Delta17-SG, revealed a larger-than-expected and structurally ill-defined loop flanking the deletion site. In the limit of a continuous space the dynamics of these networks is described by a generic evolution equation, from which some analytical predictions can be extracted. Primary or secondary cancer prevention could be greatly improved among immigrants. We reviewed our experience with pancreatectomy for non-pancreatic malignancies to determine outcomes and identify predictors of survival. In contrast to bafilomycin, none of the tested antimalarials and imidazoquinolines inhibited endosomal proteolysis or increased the endosomal pH, confirming that inhibition of pH acidification is not the underlying cause of inhibition. (1) All savanna woody species are similar in their ability to take up water from deep soil layers where its availability is relatively constant throughout the year. These peptides were identified as being encrypted in proteins produced by gut microbiota members, they do not contain cleavage points for the major intestinal endoproteases and displayed high probability to have immunomodulatory bioactivity. The testosterone-induced rise in hemoglobin and hematocrit and age-related differences in response to testosterone therapy may be mediated by factors other than erythropoietin and sTfR.

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We investigated the influence of comorbidity, Eastern Cooperative Oncology Group (ECOG) performance status and age on the efficacy and safety profile of cetuximab and irinotecan in elderly irinotecan-pretreated patients with mCRC. Polyamine-biosynthesis activity is known to be negatively regulated by intracellular polyamine pools. Boosting signal-to-noise in complex biology: prior knowledge is power. Sodium polystyrene sulfonate (SPS) is a chelating agent used for the treatment of hyperkalemia. Here, we show that TRF1 levels decrease during organismal aging both in mice and in humans. Here we describe the management of women with infertility who present in general practice with amenorrhoea or oligomenorrhoea, often the first indication of possible anovulatory infertility.

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Then the modular structure theory is introduced for strictly describe the expansion sequences. We acknowledge the limitations of case studies, however, this is a starting point in exploring the possibilities of introducing CRT as part of the treatment of AN. This particular issue highlights the need for a more effective selection process whereby those selected are more likely to complete their preregistration programme successfully, and remain employed as Registered Nurses. The effect of the opioid antagonist naltrexone on fasting hydromorphone pharmacokinetics also was evaluated. The output junctions are with anisotropic scales, saying that a scale parameter is associated with each branch of a junction and are thus named as anisotropic-scale junctions (ASJs). Community-based pharmacy practitioners have worked toward overcoming logistic and cultural barriers to make naloxone distribution for overdose prevention a standard and accepted practice. The innovative technological core of the system is based on the use of a textile conformable sensing cloth, where conducting and piezoresistive materials are integrated in form of fibres and yarns, giving rise to fabric sensors, electrodes and connections. Three of the patients were suspected of having herpesvirus lesions.

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Dentist and dental hygienist can keep clean the oral cavity of requiring long-term care and prevent the decline of oral function by professional oral function care, professional oral hygiene care and general oral care with multi-disciplinary. The influence of the coadministration of vitamin C or vitamin E on the efficacy of two thiol chelators, meso-2,3-dimercaptosuccinic acid (DMSA) or monoisoamyl DMSA, in counteracting chronic arsenic toxicity was investigated in rats. Also, the controlled drug-release behaviour of the nanocapsules was mathematically investigated. This study aimed to understand the relation between mutations of GHR gene and short stature with non-growth-hormone deficiency, and the clinical feature of the patients with the GHR gene mutations. However, more research is needed to prove their efficacy in the treatment of castration-resistant prostate cancer. Lurcher mutants had higher CO activity in all three cerebellar deep nuclei than normal littermate controls of the same background strain. Cystoid macular edema is emerging as a major cause of visual loss in HIV-infected patients with immune recovery uveitis. NGF content was measured in the prilosec dosage infants L4 dorsal root ganglion, the hindpaw skin, the L4/5 dorsal spinal cord, and the sciatic nerve, using enzyme immunoassay.

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Insect sensory organs have been a favorable model system for investigating this question for over 100 years. RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci. 125 patients with a first anterior AMI who had undergone successful reperfusion therapy were divided into 2 groups, with or without metoclopramide 10 mg during pregnancy hypertension, and into 2 further subgroups based on the presence or absence of prodromal angina. This article gives an overview of the many different technical aspects of diffusion-weighted imaging and a review of the physical and mathematical background. Crystal structure and stereochemical studies of KD(P)G aldolase from Thermoproteus tenax. Reactive oxygen species (ROS) are produced in many metabolic and physiologic processes. Subliminally and Supraliminally Acquired Long-Term Memories Jointly Bias Delayed Decisions. We suggest the removal of dislocated lens in the anterior chamber by the intracapsular extraction.

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Unlike most of the cases reported in the literature, our cozaar 50 mg image patient had partial recovery of his neurologic deficits. Uricase is a peroxisomal liver enzyme that catalyzes the oxidation of uric acid to allantoin during purine catabolism. The activated platelet surface serves as an integral part of the prothrombinase complex upon activation by potent platelet agonists such as thrombin and collagen. The In-house genotyping system had a high concordance with commercial TRUGENE(TM) or ViroSeq(TM) genotyping system. Treatment and outcomes of tumor-induced osteomalacia associated with phosphaturic mesenchymal tumors: retrospective review of 12 patients. Recall of antibody synthesis to the primary antigen following successive immunization with heterologous albumins. Seventy-five genes were overexpressed in cells from the enriched vaccine. Recognizing the association may lead to early discontinuation of SRL, which may prevent permanent disfigurement.

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The miRNA-183 family members are expressed in vertebrate sensory hair cells, in innervated regions of invertebrate benicar 40 mg recall deuterostomes, and in sensilla of Drosophila and C. Wild-type 6-19 IgA secreted by implanted cells induced significant formation of glomerular lesions, whereas poorly O-glycosylated 6-19 IgA glycovariants or a 6-19 IgA hinge mutant lacking O-linked glycans did not. We investigated the functional magnetic resonance imaging (fMRI) activation pattern of a motor task in patients with acute subcortical lesions to examine the relationship between activation pattern and recovery of motor impairment. Within the sixth intravesical instillation, he presented with polyarthritis confirmed by musculoskeletal ultrasound. The presence of significant NBV decreases only in the group of RRMS patients with the ApoE epsilon4 genotype provides new evidence that links ApoE epsilon4-related impaired mechanisms of cell repair and severe tissue destruction in MS. Although pulmonary endarterectomy (PEA) is potentially curative in chronic thromboembolic pulmonary hypertension (CTEPH), some patients have distally distributed disease that is not amenable to surgery.

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The effects of three immunosuppressants (rapamycin, FK506 and cyclosporin A) on the proliferation and differentiation of rat osteoblasts-like osteosarcoma cell line, ROS 17/2.8 (ROS) cells were examined in vitro. The genetic variations of FUT1 gene at nucleotide position 307 of its open reading frame were investigated by PCR-RFLP in a total of 245 pigs from 3 exotic pig breeds and 3 Chinese native pig breeds. Department of Ophthalmology, the Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. Using the excimer laser Esiris (Schwind, Germany), 10 patients had undergone PRK and 13 LASIK. The analysis of FAS-670A/G and FASL-844C/T polymorphisms were carried out using the PCR-RFLP approach, on 102 infertile men and 110 normal fertile men as control group. Biodegradation by bioaugmentation of dairy wastewater by fungal consortium on a bioreactor lab-scale and on a pilot-scale. Without a thorough understanding about how small rodents behave in their environment and consideration of how they react to management efforts, management will not be optimal. Isolation of supercoiled colicinogenic factor E 1 DNA sensitive to ribonuclease and alkali. Mouse killing by rats: roles of hunger and thirst in its initiation and maintenance.

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Late hormonal levels, semen parameters, and presence of antisperm antibodies in patients treated for testicular torsion. In two cases an increase in QTc time was observed, severe bradycardia was also observed twice. Myosin heavy-chain mutations that disrupt Caenorhabditis elegans thick filament assembly. Suppression of stathmin expression by transfection with small interfering RNA (siRNA) suppressed EtsT cell proliferation. The elk1 gene, when expressed in Xenopus oocytes, encodes a slowly activating and slowly deactivating potassium channel.

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