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Acyclovir

Acyclovir is approved by the Food and Drug Administration as a prescription drug that is commonly used as a topical, injectable, and oral treatment for genital herpes and cold sores. Herpes viral infections are very common. Genital herpes refers to a sexually transmitted disease (STD).

Other names for this medication:
Aciherpin, Acivir, Acloriv, Aclovir, Acvirall, Acycloguanosine, Acyclovir, Acylab, Alovir, Axovir, Cevirin, Civir, Cloviderm, Clovir, Clyvir, Cutivir, Cycloex, Cyclopiz, Docvir, Herperax, Herporax, Herpovir, Kayvir, Lovir, Lyrovir, Nisivir, Ocurax, Okavir, Ophtrhovir, Optiviral, Oveer, Psyvir, Ridoherp, Rivol, Rowapil, Setuvir, Spaclovir, Trikase, Virex, Viroderm, Viroxit, Virucid, Vivorax, Zovir, Zoylex

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Description

Acyclovir (acyclovir) is an antiviral drug. Acyclovir slows the growth and spread of the herpes virus in the body.

Acyclovir is used to treat infections caused by herpes viruses, such as genital herpes, cold sores, shingles, and chickenpox.

Acyclovir will not cure herpes, but it can lessen the symptoms of the infection.

Dosage

Patient information about the treatment of herpes, chickenpox, or shingles is available with this medicine. Read it carefully before using this medicine.

Acyclovir is best used as soon as possible after the symptoms of herpes infection or shingles (for example, pain, burning, blisters) begin to appear.

If you are taking acyclovir for the treatment of chickenpox, it is best to start taking acyclovir as soon as possible after the first sign of the chickenpox rash, usually within one day.

Acyclovir capsules, tablets, and oral suspension may be taken with meals or on an empty stomach.

Acyclovir is best taken with a full glass (8 ounces) of water.

If you are using acyclovir oral suspension, use a specially marked measuring spoon or other device to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid.

To help clear up your herpes infection, chickenpox, or shingles, keep taking acyclovir for the full time of treatment, even if your symptoms begin to clear up after a few days. Do not miss any doses. However, do not use this medicine more often or for a longer time than your doctor ordered.

If you are taking acyclovir capsules, tablets, or oral suspension, you should drink plenty of water to avoid becoming dehydrated.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (capsules, oral suspension, or tablets): For treatment of genital herpes: Adults and children 12 years of age and older—200 milligrams (mg) five times a day for ten days. Children up to 12 years of age—Use and dose must be determined by the doctor. For prevention of recurrent outbreaks of genital herpes infections: Adults and children 12 years of age and older—200 to 400 mg two to five times a day for five days or up to twelve months, depending on how often your outbreaks of infection occur. Children up to 12 years of age—Use and dose must be determined by the doctor. For treatment of chickenpox: Adults and children who weigh over 88 pounds (40 kilograms)—800 mg four times a day for five days. Children 2 years of age and older and weighing 88 pounds (40 kilograms) or less—Dose is based on body weight and must be determined by the doctor. The usual dose is 20 mg per kilogram (kg) of body weight, up to 800 mg, four times a day for five days. Children up to 2 years of age—Use and dose must be determined by the doctor. For treatment of shingles: Adults and children 12 years of age and older—800 mg five times a day for seven to ten days. Children up to 12 years of age—Use and dose must be determined by the doctor. For injection dosage form: For treatment of herpes of the brain, genitals, or mucous membranes, or for the treatment of shingles: Adults and children 12 years of age and older—Dose is based on body weight and must be determined by the doctor. The usual dose is 5 to 10 mg of acyclovir per kg (2.3 to 4.5 mg per pound) of body weight, injected slowly into a vein over at least a one-hour period, and repeated every eight hours for five to ten days. Children up to 12 years of age—Dose is based on body weight and must be determined by the doctor. The usual dose is 10 mg to 20 mg of acyclovir per kg (4.5 mg to 9.1 mg per pound) of body weight, injected slowly into a vein over at least a one-hour period and repeated every eight hours for seven to ten days. For treatment of widespread herpes virus infection in newborns: Infants from birth to 3 months of age—Dose is based on body weight and must be determined by the doctor. The usual dose is 10 mg of acyclovir per kg (4.5 mg per pound) of body weight, injected slowly into a vein over at least a one-hour period and repeated every eight hours for ten days.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Acyclovir dosage information

Side effects

The most common side effects associated with Acyclovir are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Herpes infections are contagious and you can infect other people, even while you are being treated with Acyclovir. Avoid letting infected areas come into contact with other people. Avoid touching an infected area and then touching your eyes. Wash your hands frequently to prevent passing the infection to others.

Taking this medicine will not prevent you from passing genital herpes to your sexual partner. Avoid sexual intercourse while you have active lesions or the first symptoms of an outbreak. Genital herpes may still be contagious through "viral shedding" from your skin, even if you have no symptoms.

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Structural basis for acceptor substrate recognition of a human glucuronyltransferase, GlcAT-P, an enzyme critical in the biosynthesis of the carbohydrate epitope HNK-1. CAT2 arginine transporter deficiency significantly reduces iNOS-mediated NO production in astrocytes. Intima-media thickening of the radial artery after transradial intervention. A randomized trial of accelerated hyperfractionated radiation therapy and bis-chloroethyl nitrosourea for malignant glioma. Compact two-photon fluorescence microscope based on a single-mode fiber coupler. This study investigates the role that decreased ATP levels may play in dibutyltin (DBT)-induced decreases in the tumor-cell-lysing (lytic) function of natural killer (NK) cells. The construction and use of a small and inexpensive apparatus for filter paper electrophoresis. The sensitivity to the neuroexcitatory and inhibitory activities of imidacloprid varied independently among individuals in each population. Following a 30-min lag, the bacteria migrated in a gradual and staggered movement toward and ultimately exited the mouth. Prolonged administration of weekly paclitaxel and trastuzumab in patients with advanced breast cancer.

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To examine whether postoperative dextromethorphan (DM), an antitussive and also an NMDA antagonist, intramuscular injection (I.M.) reduced pain and analgesic requirement after modified radical mastectomy (MRM). The declaration of Warsaw, the Marco Agreement and other sanitary measures forehead the habit to tobacco, are clear examples of this medical-social restlessness that tries to exile the smoking as a social, conventional and good seen conduct to try a prevention and a greater quality of life of the individuals. The concentrations of most amino acids, and total nitrogen content, increased during infection. Circulating endogenous granulocyte colony-stimulating factor levels after bone marrow transplantation. Although the Dictyostelium-based assay described in this report may not securely predict the teratogenic potential of these drugs in humans, this organism may be qualified for rapid large-scale screenings of synthetic compounds under development as new pharmaceuticals for their potential to interfere with developmental processes and thus help to reduce the amount of teratogenicity tests in animal models. The main theme is that in solution the conventional one-bond-flip mechanism dominates, while in frozen media (or under other forms of supramolecular constraint) the hula-twist mechanism takes over. Wound healing response in the presence of stromal irregularities after excimer laser treatment. The main symptoms - bladder pain and urinary frequency - may completely govern the life of the unlucky person suffering from the disease. Relationships are tested in a sample of observations from over 200 Fortune 1000 firms.

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We analyzed population count data obtained from the IBGE Foundation and mortality data obtained from the System of Information on Mortality of the DATASUS of the Ministry of Health. Clinically significant depressive symptoms may be common in individuals with very mild or mild DAT, although they may fluctuate. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Therefore, for patients who originate from areas where leprosy is endemic and who suffer from joint complaints in combination with skin or sensibility disorders, the diagnosis of leprosy should be considered. After fatigue, however, greater failure of voluntary activation was observed compared with reported values for other upper and lower extremity muscles, which may have implications for the understanding and treatment of rotator cuff pathology. As expected, a large portion of the genes show tissue specific expression in agreement with mappings to gene descriptions, Gene Ontology terms and KEGG pathways. The shift seemed to be caused by a cycle other than the index cycle, which appeared temporarily in the course. Results of a survey of indications, measuring technique and critical pressure value. The current level of sensitivity of the 32P-labelled 900bp RsaI probe is 500 pg of homologous DNA, corresponding to 5 x 10(4) mycoplasmas. Allergic reactions to anaesthetics: economic aspects of pre-operative screening.

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Ulcerative colitis and colorectal carcinoma: DNA-profile, laminin-5 gamma2 chain and cyclin A expression as early markers for risk assessment. Though cranial CT scan failed to find out new abnormality, T2-weighted cranial MRI disclosed high intensity spot over left pontine base located between medial lemniscus and pyramidal tract, which was supposed to coincide to fascicle of left abducens nerve Three months later, he recovered in the same manner as 2 years before. The article illustrates the importance of face lifting and S.M.A.S. These changes are accompanied by an increase in the filterability of RBCs. Riboflavin activated by ultraviolet A1 irradiation induces oxidative DNA damage-mediated mutations inhibited by vitamin C. The effect of parental age, birth order and other variables on early childhood mortality: a Caribbean example.

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Assessment of the markedly elevated concentration of free cystine in conjunctival tissue from patients with cystinosis permits a rapid, simple, and unequivocal diagnosis of this disorder of amino acid metabolism. Letters are written to physicians and pharmacists providing care to these patients. At some dendritic spines, alpha-fodrin was present in the necks but not in the heads, whereas beta-spectrin was present at significant levels in the spine heads. To investigate whether chronic peripheral ouabain treatment affects the brain endothelin system. Micro fibre optic flow checker for the medical analysis application. However, ultrastructural alteration of the epidermis/dermis may be caused by laser treatment. The above findings strongly support the discontinuation of resuscitation if a baby remains asystolic at 10 minutes. C1q, but not the structurally related mannose-binding lectin was found to bind to imMDC in a dose-dependent manner and induced NF-kappaB translocation to the nucleus. We observed shared polymorphic sites between the two species in one allelic line and strikingly similar haplotypes in another allelic line. Compared with control studies, both GLP-1-(7-36)NH(2) and GLP-1-(7-37) significantly increased acute insulin response to glucose, glucose disappearance constant, glucose effectiveness, and glucose effectiveness at zero insulin, but did not change the insulin sensitivity index.

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In this paper, we investigate the effect of noises on switching in single and coupled genetic toggle switch systems in Escherichia coli. Application of aesthetic sub-unit principle in nasal reconstruction and repairing of nasal defects. Psoriatic arthritis is a joint-damaging disease--a call for action!. Dexamethasone 4 mg orally twice daily was given around the time of chemotherapy administration to prevent the dermatitis associated with the drug. Determination of clinicomorphological characteristics of acute gastroduodenal erosions and ulcers in unstable course of IHD and the role of disorders in microcirculation, hemostasis, gastric function in development of these erosions. The sensor is constructed via covalent coupling between amine-terminated polyamidoamine dendrimer and silanized glass through an amide bond. Reduction of alveolar height and width after tooth extraction may provide some problems in implant placement, especially in the anterior maxilla for esthetic reasons. Combined with technical achievements in gene transfer, a better understanding of metabolic regulation provides new more precise and targeted means of modifying plant products in order to improve health and well being through diet.

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