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Actos

Actos is an add-on medication to diet and exercise to control blood sugar in people with type 2 diabetes. Actos is a thiazolidinedione that improves your body's ability to use insulin to lower your blood sugar. The typical dose for Actos is 1 tablet (either 15 mg or 30 mg) taken by mouth daily.

Other names for this medication:
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Also known as: Pioglitazone

Description

Actos is a medication that’s used to treat type 2 diabetes. This is a condition in which where your body has a high level of glucose (sugar) in your blood. Your pancreas normally makes a hormone called insulin, which takes glucose out of your blood and helps you use the sugar as a source of energy. With type 2 diabetes, your pancreas may not be making enough insulin to remove the sugar from your blood.

And if you have type 2 diabetes, your cells may also become insulin resistant. This means that your body makes insulin but isn’t responding to it by removing the sugar from your blood. So people with type 2 diabetes have high blood sugar levels.

What Actos does

Actos works by making your cells more sensitive to insulin. The goal is for your cells to take the glucose in your blood and use it more effectively as an energy source. Because you’re using your glucose more effectively, your blood glucose levels will decrease.

This lowers your risk of serious complications of type 2 diabetes, including heart disease, nerve damage such as neuropathy, and kidney failure.

How long does it take to work?

After you start using Actos, it may take 7 days or longer before you notice any changes in your blood glucose level. It’s important to keep taking Actos every day so that it can have the best chance to work in your body.

Dosage

The Actos dosage your doctor prescribes will depend on several factors. These include:

  • the type and severity of the condition you’re using Actos to treat
  • other medical conditions you may have, such as congestive heart failure (CHF)*
  • other medications that you’re taking to treat your type 2 diabetes
Typically, your doctor will start you on a low dosage. Then they’ll adjust it over time to reach the amount that’s right for you. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

* <em>Actos</em> has a<em> boxed warning</em> for CHF. This is the most serious warning from the FDA. For more information, see “FDA warning: Congestive heart failure” at the beginning of this article.

Drug forms and strengths

Actos comes as a tablet that you swallow, and you’ll usually take it once a day. Actos is available in three strengths: 15 mg, 30 mg, and 45 mg.

Dosage for type 2 diabetes

Your doctor will likely have you start taking either a 15-mg or 30-mg dose of Actos once a day. If needed, they may increase the dose by 15 mg for extra control of your blood sugar. The maximum dose of Actos is 45 mg a day.

Your starting dose will depend on if you have other health conditions, such as CHF.* And the dose will be increased over time based on how your body responds.

And in some situations where your body may be very stressed, your doctor may need to change your dose or have you stop taking Actos. So tell your doctor right away if you:

  • have a fever
  • have an infection
  • have had an accident
  • have just had or will have surgery
Never change your dosage of Actos without first talking with your doctor. And before you start taking Actos, be sure to tell them about any medical conditions you have or any other medications that you take. Your doctor will determine what the best dosage is for you.

* Actos has a boxed warning for CHF. This is the most serious warning from the Food and Drug Administration (FDA). For more information, see “FDA warning: Congestive heart failure” at the beginning of this article.

What if I miss a dose?

If you miss your dose, wait and take Actos when your next dose is due. Never take two doses in 1 day. If you have questions on when to take your next dose of Actos after you’ve missed a dose, talk with your doctor or pharmacist.

To help make sure that you don’t miss a dose, try setting a reminder on your phone. A medication timer may be useful, too.

Will I need to use this drug long term?

Actos is meant to be used as a long-term treatment. If you and your doctor determine that Actos is safe and effective for you, you’ll likely take it long term.

Overdose

If an overdose occurs and you are not feeling well, you should seek emergency medical attention or contact your health care provider immediately. You can experience the following symptoms of Actos overdose: signs of low blood sugar, such as extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Actos are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Actos if you are allergic to Actos ingredients. Do not take Actos if you are in a state of diabetic ketoacidosis. Actos is ineffective and possibly harmful in treatment of type 1 diabetes. Do not take Actos if you have congestive heart failure or heart disease, fluid retention, a history of bladder cancer, heart attack, stroke, liver disease, certain eye problems (macular edema), or polycystic ovary syndrome. Actos is not to be used in people with blood in their urine when the cause of this is unknown. Avoid drinking alcohol. It lowers blood sugar level and may interfere with your diabetes treatment. Be careful with Actos if you are pregnant, planning to become pregnant, or breastfeeding. Do not use Actos in treatment of children under 18 years old. Actos may increase the risk of bone fracture in women (usually in the upper arm, hand, or foot). Actos can cause changes in the menstrual cycle (promote ovulation) and increase the risk of becoming pregnant. Do not take Actos for longer than recommended. Taking Actos for more than 1 year may increase your risk of developing bladder cancer.

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