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Actical (Calcitriol)
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Actical

Actical is an active metabolite of vitamin D that is used to treat hyperparathyroidism and is also used in dialysis patients to combat hypocalcemia. Actical is a biologically active calcitrophic hormone with anti-osteoporotic, immunomodulatory, anticarcinogenic, antipsoriatic, antioxidant, and mood-modulatory activities.

Other names for this medication:
Admax, Alfacal, Alfacalcirol, Alfacip, Arachitol, Arcium, Biocitral, Calasto, Calcibest, Calcicare, Calcigra, Calcikind, Calcimet, Calfa, Calotec, Calsonic, Caltive, Caltop, Cholical, Citroj, Coecoral, Dmcal, Estovon, Fovit, Laretol, Netxod, Refirm, Riecal, Ritoca, Roical, Rolsical, Romical, Septriol, Solbiocal, Sunmic

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Catapres, Zofran, Sumycin, Lexapro, Panadol, Nolvadex, Ventolin, Strattera, Cardura, Desyrel, Miambutol, Intralor, Serex, Lexis, Broncure, Hepavud, Theraprim, Lipivim, Atovarol,

Also known as: Calcitriol

Description

Generic Actical is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Actical are intestine and bone. Generic Actical receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Actical may also act on the kidney and the parathyroid glands. Generic Actical is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Actical has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Actical, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Actical in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Actical produces other independent beneficial effects. Actical is also known as Calcitriol. Generic Actical treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Actical is Calcitriol. Brand name of Generic Actical is Actical.

Dosage

Generic Actical is available in capsules (0.25 mcg) and liquid form. Capsules must be swallowed whole. Do not crush or chew them. If you are prescribed the liquid form, use as directed. Follow dosing instructions closely. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. If you want to achieve most effective results do not stop taking Generic Actical suddenly.

Overdose

If you overdose Generic Actical and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Actical are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Generic Actical if you are allergic to Generic Actical components. Do not take Generic Actical if you are pregnant, planning to become pregnant, or are breast-feeding. It is not known if this medication appears in breast milk. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Be careful with Generic Actical if you have heart disease, kidney disease or kidney stones, coronary artery disease (hardening of the arteries). Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. It can be dangerous to stop Generic Actical taking suddenly.

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Prevalence of dracunculiasis among Nigerian school children as an index of prevalence in their communities of origin. On the other hand, decrease of PBL response to in vitro IFN-beta action was related to augmentation of IFN-alpha and IFN-gamma production in the secondary progressive MS. All strains of Yersinia pestis examined have been found to lack an O-antigen. The alveolar septal thickening was suspected to be a pathological change following pulmonary alveolar proteinosis. All individuals with a family history of premature heart disease should have a thorough coronary risk assessment performed, which can be initiated in an office visit. Before a split-liver, cholangiography and arteriography should be performed to detect anatomical variations without performing an extensive dissection which may endanger the vascularity of the bile ducts. Development of valvular lesions in metastatic carcinoid disease. Seven d HDBR leads to changes of VCG parameters, which were all in normal ranges and in accordance with the volume changes of atrium and ventricle, but obviously different from those resulted from pathological ventricular thickening and myocardial ischemia. The data on transplantation in Saudi Arabia are complex and require additional framework for interpretation. Barbiturate spindle activity in the thalamic lateral ventro-posterior nucleus and the second somato-sensory area of the cortex.

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Federal Court of Appeals overturned a lower court ruling and permitted an HIV positive man to sue the Secretary of State for alleged discrimination in hiring. New system for automated extraction and simultaneous determination of serum cholesterol and triglycerides. Interictal spikes in the fusiform and inferior temporal gyri of an epileptic patient with colored eulexin medication elementary visual auras: a 5-year longitudinal MEG ECD study. Correlations of TLA and disability in this study were rather strong. Osmotically induced membrane tension modulates membrane permeabilization by class L amphipathic helical peptides: nucleation model of defect formation. Binding tests with recombinant deletion mutants suggested that the primary binding site on C4bp is located on the alpha-chain complement control protein 4 domain. Mechanisms underlying the manipulation of host apoptotic pathways by Toxoplasma gondii. Nature of slow dynamics in a minimal model of frustration-limited domains. This proof is wanting since recent work demonstrates that the venous drainage of the intrapulmonary bronchi flows into the pulmonary vascular system at the precapillary level.

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We show that p18(Hamlet) interacts with p53 and stimulates the transcription of several proapoptotic p53 target genes such as PUMA and NOXA. The inverse correlation between amylin and glucagon secretion suggests that amylin modulates glucagon secretion following oral glucose administration. Double-immunolabeling for progesterone receptor and either calbindin or parvalbumin was performed on hypothalamic Vibratome sections of estrogen primed African green monkeys (Cercopithecus aethiops). Thus, at pH 6.5, the protons released during the binding of substrate may be from its thiol group. One hundred and twenty non-insulin-dependent diabetics (NIDDs) aged 50-70 years and 93 non-diabetic subjects, matched for age and sex, were studied using Doppler ultrasound. Significance of various pathways of transmission of Brucella among saiga. Although the analysis for alcohol consumption was not significant, there was a trend toward better outcomes nifedipine adalat cc 60 mg for male participants in the EC condition. From November 1997 to May 2007, 28 patients underwent a thoracic endovascular stent-graft procedure for acute symptomatic type B dissection at our institution. Adjunctant hyperbaric oxygen therapy led to clinical and radiological improvement.

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We demonstrated that the antiproliferative effect of type 1 interferons on human liver cancer cells correlates with levels of transcription of the interferon regulatory factor-1 gene in parallel with those of p21(WAF-1) expression. International implications of the study findings are also addressed. One relies on the assumption that cancer is environmentally caused whereas the other assumes that genetic determinants are playing a major role in the pathogenesis of human malignancies. Spontaneous pneumoperitoneum localized in the left posterior pararenal space in acute pancreatitis. SSc patients surviving SRC who have serum antibodies to Th/To, RNA polymerase III, or U3 RNP are at increased risk to develop PHT. Gender-specific patterns of gene expression also appeared to be different between these two populations. The results from this study suggest that short bouts of exercise may ameliorate some of the increases in sleepiness and fatigue associated with sleep loss for a short period of time but are not likely to prevent performance decrements. Domains of colloidal size, mediated by self-assembly of small molecules in a polymer matrix: a three-level hierarchy of assembly. Four new saponins, designated as certonardosides K-N (1-3, 5), were isolated, along with culcitoside C(6) (4), from the brine shrimp active fraction of the starfish Certonardoa semiregularis.

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