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Abilify (Aripiprazole)

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Abilify is a medication that works in the brain to treat schizophrenia. It is also known as a second generation antipsychotic (SGA) or atypical antipsychotic. Abilify rebalances dopamine and serotonin to improve thinking, mood, and behavior.

Other names for this medication:
Apicord, Aridus, Arifril, Arilan, Arinex, Aripat, Aripicon, Aripiprazole, Aripra, Arpicin, Asprito, Biliff, Elrip, Pipra, Rizotal, Schizopra

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Also known as: Aripiprazole


Aripiprazole is used alone or together with other medicines to treat mental conditions such as bipolar I disorder (manic-depressive illness), major depressive disorder, and schizophrenia. It is also used in children to treat irritability associated with autistic disorder and Tourette syndrome. Aripiprazole works in the brain to change how certain chemicals affect patients. It is an antipsychotic agent.

This medicine is available only with your doctor's prescription. Abilify® oral solution was withdrawn from the market on May 15, 2015 and this dose form is not marketed by any generic manufacturers.


This section provides information on the proper use of a number of products that contain aripiprazole. It may not be specific to Abilify Discmelt. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

If you are using the orally disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not open the blister pack that contains the tablet until you are ready to take it. Remove the tablet from the blister pack by peeling back the foil, then taking the tablet out. Do not push the tablet through the foil. Do not break or split the tablet. Place the tablet in your mouth. It should melt quickly. After the tablet has melted, you may swallow or take a sip of water.

Swallow the tablets whole. Do not break, crush, or chew them.

Abilify Mycite® has a sensor in the tablet, which helps track it inside the stomach or bowels. The Abilify Mycite® System comes with a patch (wearable sensor), a smartphone application (app), and a web-based portal. Follow your doctor's instructions on how to use the medicine.

The Abilify Mycite® tablet is usually detected within 30 minutes after you take it, but there may be a delay of more than 2 hours for the smartphone app and web portal to detect that you have taken the medicine, and sometimes it might not be detected at all.

To apply the Abilify Mycite® patch:

The app will tell you when to apply or remove the patch. It should be changed weekly or sooner as needed. Place the patch to the left side of your body just above the lower edge of your rib cage. Do not put the patch in areas where the skin is scraped, cracked, inflamed, or irritated, or near the area where you had removed the previous patch. The app will help you place the patch in the correct location. You may keep the patch on when showering, swimming, or exercising.

Aripiprazole may be taken with or without food. If your doctor tells you to take it a certain way, follow your doctor's instructions.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (tablets and orally disintegrating tablets): For bipolar mania: Abilify® and Abilify Discmelt®: Adults—At first, 15 milligrams (mg) once a day. When it is given with lithium or valproate, the starting dose is 10 to 15 mg once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 30 mg per day. Children 10 years of age and older—At first, 2 mg once a day. The dose will be gradually increased to 10 mg once a day. Your doctor may adjust your dose again as needed. However, the dose is usually not more than 30 mg per day. Children younger than 10 years of age—Use and dose must be determined by your doctor. Abilify Mycite®: Adults—At first, 15 milligrams (mg) once a day. When it is given with lithium or valproate, the starting dose is 10 to 15 mg once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 30 mg per day. Children—Use and dose must be determined by your doctor. For depression: Adults—At first, 2 to 5 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 15 mg per day. Children—Use and dose must be determined by your doctor. For irritability in children with autistic disorder: Children 6 to 17 years of age—At first, 2 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 15 mg per day. Children younger than 6 years of age—Use and dose must be determined by your doctor. For schizophrenia: Abilify® and Abilify Discmelt®: Adults—At first, 10 to 15 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 30 mg per day. Children 13 to 17 years of age—At first, 2 mg once a day. The dose will be gradually increased to 10 mg once a day. Your doctor may adjust your dose again as needed. However, the dose is usually not more than 30 mg per day. Children younger than 13 years of age—Use and dose must be determined by your doctor. Abilify Mycite®: Adults—At first, 10 to 15 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 30 mg per day. Children—Use and dose must be determined by your doctor. For Tourette's disorder: Children 6 to 18 years of age—At first, 2 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 20 mg per day. Children younger than 6 years of age—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include drowsiness, vomiting, aggression, confusion, tremors, fast or slow heart rate, seizure (convulsions), weak or shallow breathing, fainting, or coma.


Store Abilify at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Abilify are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Generic Abilify if you are allergic to Generic Abilify components. Do not take Generic Abilify if you're pregnant or you plan to have a baby, or you are a nursing mother. Generic Abilify is not for use in psychotic conditions that are related to dementia. Generic Abilify has caused fatal heart attack and stroke in older adults with dementia-related conditions. Avoid using other medicines that make you sleepy (such as cold medicine, pain medication, muscle relaxers, and medicine for seizures, depression or anxiety). They can add to sleepiness caused by Generic Abilify. Avoid becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise. It is easier to become dangerously overheated and dehydrated while you are taking Generic Abilify. Be careful with Generic Abilify if you have liver or kidney disease, heart disease, high blood pressure, heart rhythm problems, a history of heart attack or stroke, a history of breast cancer, seizures or epilepsy, trouble swallowing, a personal or family history of diabetes, phenylketonuria. Generic Abilify may cause you to have high blood sugar (hyperglycemia). Talk to your health care provider if you have any signs of hyperglycemia such as increased thirst or urination, excessive hunger, or weakness. If you are diabetic, check your blood sugar levels on a regular basis while you are taking Generic Abilify. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Be careful with Generic Abilify if you are taking a medication to treat high blood pressure or a heart condition; carbamazepine (Tegretol), phenobarbital (Luminal, Solfoton), or phenytoin (Dilantin); rifabutin (Mycobutin) or rifampin (Rifadin, Rimactane, Rifater); ketoconazole (Nizoral), itraconazole (Sporanox); quinidine (Cardioquin, Quinaglute); fluoxetine (Prozac), fluvoxamine (Luvox), or paroxetine (Paxil). Avoid alcohol. Do not stop taking Generic Abilify suddenly.

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The agonistic and antagonistic effects of RP S19122-145 dimers and trimers were reflected by monocytic, THP-1-derived macrophage-like cells. These data indicate that avian DJD is body mass mediated in broiler strain fowl, and that proteoglycan distribution is altered in diseased cartilage. Therefore, this delay may compromise timely management of HIV infected individuals and enhances propagation of the epidemic in our country. Therefore, it is important to develop more effective therapies to reverse EGFR-TKIs resistance. As to measuring units, there is considerable variation in the way speech intensity is measured and quantified. The p38 MAP kinase and the c-Jun NH2-terminal protein kinase (JNK) have been shown to be preferentially activated by oxidative stress.

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Recently, levosalbutamol to be administered via a pressurized metered dose inhaler (pMDI) has been developed. Moreover, blockage of activation of CPP32/caspase-3 by pretreating the cells with two specific tetrapeptidic inhibitors for caspases (Ac-DEVD-cho and Ac-YVAD-cmk) could significantly attenuate the extent of cleavage/activation of PAK2 induced by UV irradiation. Dye-doped liquid crystals as high-resolution recording media: errata. Thirty patients (27 of whom had transglottic tumors) met the study criteria (resected T3-T4 laryngeal cancer, histologically negative cervical nodes, and no other adverse histopathology). Long-term use of COX-2 inhibitors for the chemoprevention of colitic cancer is needed to define their mechanism of action, that reduce side effects and have specific tumor target. In this review, we summarize the genetic regulatory network underlying photoperiodic responses in soybean. The p38 inhibitor (SB203580) blocked CH-induced COL1A1 and SPP1 gene expression. Normal liver, fibrotic liver in different stages and cirrhotic liver sections were studied. These effector molecules bind interdependently to three anti-cooperative binding sites on the trimeric PII protein and thereby affect its structure. This paper investigates the problem of stability analysis for recurrent neural networks with time-varying delays and polytopic uncertainties.

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The aim of present study was to compare the effects of branched-chain amino acid (BCAA) supplementation taken before or after exercise on delayed onset muscle soreness (DOMS) and exercise-induced muscle damage (EIMD). Although South Koreans have a low prevalence of obesity, little information is available about the prevalence of the metabolic syndrome and its associated risk factors. Effect of diazocine bridgehead modification on the folding of the Wilcox molecular torsion balance: a view from a different angle. Extraction paper chromatography technique for the radionuclidic purity evaluation of 90Y for clinical use. The steady-state level of c-myc transcripts increases in cells exposed to high temperatures. Irreversible loss of negative surface charge and loss of colony-forming ability in Burkitt lymphoma cells after x-irradiation. Data was analysed through constant comparison and theoretical coding. The method of affinity labeling has been used to identify protein components of 50S ribosomal subunits involved in peptidyl transferase activity. The use of microrobots for controlled drug delivery shows great potential to achieve precise targeting with controllable side effects. Work ability of white-collar workers in commercial services industry was strongly associated with psychosocial factors at work such as teamwork, stress handling, and self-development and, to a lesser extent, with stressful life events, lack of physical activity, and obesity.

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We changed lecture with team-based learning method to teach four topics in a 2-week medical ethics clerkship, while the remaining topics were taught by lectures. The increase was due entirely to the much higher expenditures for Part B services under cost reimbursement. The lack of inflammation on biopsy and the different ages at onset and patterns of muscle weakness distinguish s-IBM from h-IBM. One explanation may be that deficits in the stress system are associated specifically with a biological vulnerability to insomnia rather than the phenotypic expression of insomnia. Impact of Tocilizumab Monotherapy on Clinical and Patient-Reported Quality-of-Life Outcomes in Patients with Rheumatoid Arthritis.

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The authors report a case of gallstone ileus of the sigmoid colon in an 80-year-old woman admitted to the hospital with symptoms and signs of large bowel obstruction and asymptomatic cholelithiasis. The combination of a vascular endothelial growth factor (VEGF) -neutralizing antibody, bevacizumab, and irinotecan is associated with high radiographic response rates and improved survival outcomes in patients with recurrent malignant gliomas. The modification of metal-ceramic constructions with zofran liquid pediatric dose reference to dental trephining. What is the physiological function of Yes-associated protein-1 (Yap1), a susceptibility gene for polycystic ovary syndrome (PCOS), in ovarian granulosa cells (GCs)?. Similar pharmacological properties of 8-OH-DPAT and alnespirone (S 20499) at dopamine receptors: comparison with buspirone. Substituent effects on monoboronic acid sensors for saccharides based on N-phenyl-1,8-naphthalenedicarboximides.

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Prostate specific antigen (PSA) response, overall survival, and grade 3 to 4 toxicity were analyzed. We tested the effects of NG-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide (NO) synthesis, on plasma levels of interleukin (IL) IL-6, IL-8, tumor necrosis factor-alpha (TNFalpha) and nitrite/nitrate (NO2-/ NO3-) in patients with severe septic shock. TNF-alpha receptor 1 expression on acute myeloid leukemic blasts predicts differentiation into leukemic dendritic what kind of medication is dilantin cells. Scheuermann disease: evaluation of radiological criteria and population prevalence. While natural selection thus does not appear to operate on protein folding rates, the majority of the designed proteins unfold considerably faster than their naturally occurring counterparts, suggesting possible selection for a high free energy barrier to unfolding.

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Moreover, patch-clamp studies indicated the presence of few Cl- cAMP-dependent conductance CFTR channels on unpolarized cells, and a larger number of CFTR channels on the apical plasma membranes of polarized cells. Splenic abscess is one of the rarest complications of the UVC in a newborn and it is hypothesized that it could be due to an infection or trauma caused by a catheter. Localized modes can exist in PQC without introducing defects due to the lack of translational symmetry. The second contributions to DFTB1, the DFT double counting terms, are summarized together with nuclear repulsion energy terms and can be rewritten as the sum of pairwise repulsive terms. Of the various environmental and behavioural risk factors identified as playing a role in MS onset and progression, perhaps none has been as consistent as vitamin D. The great advantage of using an integrated approach is that voles cannot become adapted to any one of the methods. By using paired sera the IgM and IgG host responses were analyzed in dogs with ELISA and Western blot techniques. Our data demonstrate that VV formation, in patients with CVI, is associated with phosphorylated pRb and the transformation of SMCs from a contractile to a secretory ultrastructural morphology. Experiments in recent years have revealed labile electrophysiological and neurochemical phenotypes in primary afferent neurons exposed to specific stimulus conditions associated with the development of chronic pain. The effects of the congeners, substances other than ethanol in whisky, on the ethanol-induced gastric mucosal damage were examined in the rat model.

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We developed an item bank for dyspnea severity and related levitra 20mg online apotheke functional limitations on the basis of a PRO conceptual framework derived from patient input. However, these approaches may not truly reflect the physical and chemical condition of freshly generated smoke. Both in the intent-to-treat and completer samples, there were no differences between the two treatment conditions in inducing recovery (no binge eating or purging behaviours for 28 days) or remission (no longer meeting DSM-IV criteria). Focus groups were audio recorded, transcribed, coded with ATLAS.ti, and analyzed for themes. Perioperative cardiorespiratory complications in adults with mediastinal mass: incidence and risk factors. Pulsed wave (PW) Doppler ultrasound systems are commonly used to examine blood flow dynamics and the technique plays a very important role in numerous diagnostic applications. Preventing kidney injury in children with neurogenic bladder dysfunction.

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Exposure of the process to the surrounding bone linked the bone to the calcified tissue formed in the pulp and caused ankylosis and infraocclusion of the affected teeth. However, most external bacteria would be inactive, whereas typical polar taxa dominate the potentially active fraction and are subsidized by external nutrient sources, thus assuming the main biogeochemical roles within the lake. Analysis of additivity and synergism in the anti-plasmodial effect of purified compounds from plant extracts. An analysis of etiological and genetic factors of a patient with familial hemophagocytic lymphohistiocytosis. Metal movement in leachate and drainage at Parc lead-zinc mine, North Wales. Is the latent structure of fear of pain continuous or discontinuous among pain patients?. Moreover, CHO cells deficient in DNA double strand break (DSB), but not single-strand break (SSB), repair, were particularly sensitive to aluminium exposure compared with repair proficient cells, suggesting that aluminium is associated with DSBs.

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Functional interneuronal connections in the motor cortex of waking and anesthetized cats. Hyaluronidase-treated chondroitin sulphate was fractionated by gel chromatography. Self-assembly polymerization enhances the immunogenicity of influenza M2e peptide. Using this approach, we have also assessed the ability of putative apoptosome regulatory proteins, such as Smac/DIABLO and PHAPI, to regulate the activity of native apoptosomes. Because metastatic RCC frequently has p53 mutations, therapy restoring p53 may markedly improve the response rate of immunochemical therapy combining IFN-alpha and 5-FU. Assessment of duodenal circular drainage in treatment of superior mesenteric artery syndrome. This score can be used to order CNV calls in such a way that calls having larger scores are more likely to overlap a true CNV. Thus, the lack of chronic immune activation and disease progression in HIV-1-infected VNPs is apparently not associated with unusual functional properties of the accessory viral Nef protein. In slices from cocaine-treated animals, putative BLA-mPFC EPSCs were depressed through a presynaptic mechanism.

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Resurgence of Pertussis and Emergence of the Ptxp3 Toxin Promoter Allele in South Italy. For life expectancy to increase appreciably by vaccination or antibiotic therapy directed against H. The location of the 19 disulfide bridges is described, and their possible structural roles are discussed in relation to the transferrin family of proteins. sterilis) accumulated higher concentrations of Cs from low external concentrations than did non-competitive plants or competitive plants grown at low nutrient levels. The prevalence of keratoconus in Jerusalem was found to be much higher than that seen in other parts of the world, except India. Amphibian skin secretion is considered as a rich source of bioactive peptides. Transpulmonary approach to the left coronary trunk (apropos of the surgical treatment of an aneurysm). The feasibility of conducting high-quality occupational data collection and coding for a large heterogeneous population-based sample was demonstrated. The article concludes by offering direction to researchers interested in integrating and extending the empirical study of the attitudes of adults facing serious illness, and underscoring the clinical implications of these findings for professionals offering psychosocial and spiritual care at the end of life. PRECREST: a phase II prevention and biomarker trial of creatine in at-risk Huntington disease.

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